A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY
The size of guinea‐pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo‐oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo‐oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not...
Gespeichert in:
| Veröffentlicht in: | British journal of pharmacology 1980-06, Vol.69 (2), p.167-169 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 169 |
|---|---|
| container_issue | 2 |
| container_start_page | 167 |
| container_title | British journal of pharmacology |
| container_volume | 69 |
| creator | ADCOCK, J.J. GARLAND, L.G. |
| description | The size of guinea‐pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo‐oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo‐oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine‐induced contractions of the guinea‐pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS‐A (slow reacting substance of anaphylaxis) antagonist, FPL55712, and the Antiallergic drug, cromoglycate, had no effect on the augmentation of histamine‐induced contractions by indomethacin. |
| doi_str_mv | 10.1111/j.1476-5381.1980.tb07886.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2044254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75336364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5436-4fa2302feb592643db0c0c346490f4c5e0924d175645f8b73de55b0dec6c26303</originalsourceid><addsrcrecordid>eNqVkd-Pk0AQxzfGy1mrf4LJxgffwIH9RX3QcEhbEs5tgKr1ZQPLojS03EHr3f33Qto0-ug87GzymfnOZL4IvXXAdoZ4v7UdKrjFiOfYzswD-1CA8DxuPz5Dkwt6jiYAICzH8bwX6GXfbwEGKNg1uuZCCAA-QT98vJJpGt3EIU7k8MxlguNoJb9vFuEXPw3xKpGf10GWYj_FSbhYx34mkxTLOfaj5Ju_wemtlNkS367TYBQJ_SCLvkbZ5hW6qvKmN6_PeYrW8zALllYsF1Hgx5ZmlHCLVrlLwK1MwWYup6QsQIMmlNMZVFQzAzOXlo5gnLLKKwQpDWMFlEZz7XICZIo-nnTvjsXOlNrsD13eqLuu3uXdk2rzWv1L9vUv9bP9rVyg1B12mKJ3Z4GuvT-a_qB2da9N0-R70x57JRghnPCx8MOpUHdt33emugxxQI3OqK0az6_G86vRGXV2Rj0OzW_-XvPSerZi4J9O_KFuzNN_KKub1XL8kT_lCJeJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75336364</pqid></control><display><type>article</type><title>A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>ADCOCK, J.J. ; GARLAND, L.G.</creator><creatorcontrib>ADCOCK, J.J. ; GARLAND, L.G.</creatorcontrib><description>The size of guinea‐pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo‐oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo‐oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine‐induced contractions of the guinea‐pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS‐A (slow reacting substance of anaphylaxis) antagonist, FPL55712, and the Antiallergic drug, cromoglycate, had no effect on the augmentation of histamine‐induced contractions by indomethacin.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1980.tb07886.x</identifier><identifier>PMID: 6777006</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Arachidonic Acids - metabolism ; Dose-Response Relationship, Drug ; Guinea Pigs ; Histamine - pharmacology ; In Vitro Techniques ; Indomethacin - pharmacology ; Lipoxygenase - physiology ; Male ; Muscle Contraction - drug effects ; Oxygenases - antagonists & inhibitors ; SRS-A - physiology ; Trachea - drug effects ; Trachea - physiology</subject><ispartof>British journal of pharmacology, 1980-06, Vol.69 (2), p.167-169</ispartof><rights>1980 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5436-4fa2302feb592643db0c0c346490f4c5e0924d175645f8b73de55b0dec6c26303</citedby><cites>FETCH-LOGICAL-c5436-4fa2302feb592643db0c0c346490f4c5e0924d175645f8b73de55b0dec6c26303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044254/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044254/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6777006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ADCOCK, J.J.</creatorcontrib><creatorcontrib>GARLAND, L.G.</creatorcontrib><title>A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>The size of guinea‐pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo‐oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo‐oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine‐induced contractions of the guinea‐pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS‐A (slow reacting substance of anaphylaxis) antagonist, FPL55712, and the Antiallergic drug, cromoglycate, had no effect on the augmentation of histamine‐induced contractions by indomethacin.</description><subject>Animals</subject><subject>Arachidonic Acids - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Guinea Pigs</subject><subject>Histamine - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Indomethacin - pharmacology</subject><subject>Lipoxygenase - physiology</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Oxygenases - antagonists & inhibitors</subject><subject>SRS-A - physiology</subject><subject>Trachea - drug effects</subject><subject>Trachea - physiology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd-Pk0AQxzfGy1mrf4LJxgffwIH9RX3QcEhbEs5tgKr1ZQPLojS03EHr3f33Qto0-ug87GzymfnOZL4IvXXAdoZ4v7UdKrjFiOfYzswD-1CA8DxuPz5Dkwt6jiYAICzH8bwX6GXfbwEGKNg1uuZCCAA-QT98vJJpGt3EIU7k8MxlguNoJb9vFuEXPw3xKpGf10GWYj_FSbhYx34mkxTLOfaj5Ju_wemtlNkS367TYBQJ_SCLvkbZ5hW6qvKmN6_PeYrW8zALllYsF1Hgx5ZmlHCLVrlLwK1MwWYup6QsQIMmlNMZVFQzAzOXlo5gnLLKKwQpDWMFlEZz7XICZIo-nnTvjsXOlNrsD13eqLuu3uXdk2rzWv1L9vUv9bP9rVyg1B12mKJ3Z4GuvT-a_qB2da9N0-R70x57JRghnPCx8MOpUHdt33emugxxQI3OqK0az6_G86vRGXV2Rj0OzW_-XvPSerZi4J9O_KFuzNN_KKub1XL8kT_lCJeJ</recordid><startdate>198006</startdate><enddate>198006</enddate><creator>ADCOCK, J.J.</creator><creator>GARLAND, L.G.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198006</creationdate><title>A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY</title><author>ADCOCK, J.J. ; GARLAND, L.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5436-4fa2302feb592643db0c0c346490f4c5e0924d175645f8b73de55b0dec6c26303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Arachidonic Acids - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Guinea Pigs</topic><topic>Histamine - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Indomethacin - pharmacology</topic><topic>Lipoxygenase - physiology</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Oxygenases - antagonists & inhibitors</topic><topic>SRS-A - physiology</topic><topic>Trachea - drug effects</topic><topic>Trachea - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADCOCK, J.J.</creatorcontrib><creatorcontrib>GARLAND, L.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ADCOCK, J.J.</au><au>GARLAND, L.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1980-06</date><risdate>1980</risdate><volume>69</volume><issue>2</issue><spage>167</spage><epage>169</epage><pages>167-169</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>The size of guinea‐pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo‐oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo‐oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine‐induced contractions of the guinea‐pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS‐A (slow reacting substance of anaphylaxis) antagonist, FPL55712, and the Antiallergic drug, cromoglycate, had no effect on the augmentation of histamine‐induced contractions by indomethacin.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6777006</pmid><doi>10.1111/j.1476-5381.1980.tb07886.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1188 |
| ispartof | British journal of pharmacology, 1980-06, Vol.69 (2), p.167-169 |
| issn | 0007-1188 1476-5381 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2044254 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Arachidonic Acids - metabolism Dose-Response Relationship, Drug Guinea Pigs Histamine - pharmacology In Vitro Techniques Indomethacin - pharmacology Lipoxygenase - physiology Male Muscle Contraction - drug effects Oxygenases - antagonists & inhibitors SRS-A - physiology Trachea - drug effects Trachea - physiology |
| title | A POSSIBLE ROLE FOR LIPOXYGENASE PRODUCTS AS REGULATORS OF AIRWAY SMOOTH MUSCLE REACTIVITY |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T22%3A54%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20POSSIBLE%20ROLE%20FOR%20LIPOXYGENASE%20PRODUCTS%20AS%20REGULATORS%20OF%20AIRWAY%20SMOOTH%20MUSCLE%20REACTIVITY&rft.jtitle=British%20journal%20of%20pharmacology&rft.au=ADCOCK,%20J.J.&rft.date=1980-06&rft.volume=69&rft.issue=2&rft.spage=167&rft.epage=169&rft.pages=167-169&rft.issn=0007-1188&rft.eissn=1476-5381&rft_id=info:doi/10.1111/j.1476-5381.1980.tb07886.x&rft_dat=%3Cproquest_pubme%3E75336364%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75336364&rft_id=info:pmid/6777006&rfr_iscdi=true |