Requirement of Apelin-Apelin Receptor System for Oxidative Stress-Linked Atherosclerosis

The recently identified endogenous peptide apelin and its specific apelin receptor (APJ) are currently being considered as potential regulators in vascular tissue. Previously, we reported apelin mediates phosphorylation of myosin light chain and elicits vasoconstriction in vascular smooth muscle. In...

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Veröffentlicht in:	The American journal of pathology 2007-11, Vol.171 (5), p.1705-1712
Hauptverfasser:	Hashimoto, Tatsuo, Kihara, Minoru, Imai, Nozomi, Yoshida, Shin-ichiro, Shimoyamada, Hiroaki, Yasuzaki, Hiroaki, Ishida, Junji, Toya, Yoshiyuki, Kiuchi, Yoshihiro, Hirawa, Nobuhito, Tamura, Kouichi, Yazawa, Takuya, Kitamura, Hitoshi, Fukamizu, Akiyoshi, Umemura, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines Animals Apelin Apelin Receptors Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Atherosclerosis - metabolism Atherosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carrier Proteins - genetics Carrier Proteins - physiology Cell Proliferation Diet, Atherogenic Intercellular Signaling Peptides and Proteins Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Knockout Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism NADPH Oxidases - metabolism Oxidative Stress Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, G-Protein-Coupled - physiology Regular
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