Influence of liver cirrhosis on sertraline pharmacokinetics

Sertraline is a serotonin reuptake inhibitor. The enhancement of serotoninergic transmission is associated with antidepressant activity. In order to determine the pharmacokinetics of sertraline in patients with chronic stable hepatic insufficiency, 10 patients were matched (age, weight, sex) with 10...

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Veröffentlicht in:	British journal of clinical pharmacology 1996-09, Vol.42 (3), p.394-397
Hauptverfasser:	DÉMOLIS, JEAN‐LOUIS, ANGEBAUD, PASCAL, GRANGÉ, JEAN‐DIDIER, COATES, PETER, FUNCK‐BRENTANO, CHRISTIAN, JAILLON, PATRICE
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylamine - analogs & derivatives 1-Naphthylamine - pharmacokinetics Adult Aged Antidepressive Agents - pharmacokinetics Biological and medical sciences Female Humans liver cirrhosis Liver Cirrhosis - metabolism Male Medical sciences Middle Aged Neuropharmacology Original pharmacokinetics Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Serotonin Uptake Inhibitors - pharmacokinetics Sertraline
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