The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide‐dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial
1We report a single‐blind randomized crossover trial comparing the efficacy of tropisetron plus dexamethasone (TROPDEX) vs conventional combination of metoclopramide, dexamethasone and diphenhydramine (METDEX) in prevention of acute and delayed vomiting in Chinese patients receiving high dose cispla...
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| Veröffentlicht in: | British journal of clinical pharmacology 1996-05, Vol.41 (5), p.403-408 |
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| container_title | British journal of clinical pharmacology |
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| creator | CHUA, D. T. T. SHAM, J. S. T. AU, G. K. H. CHOY, D. KWONG, D. L. W. YAU, C. C. CHENG, A. C. K. |
| description | 1We report a single‐blind randomized crossover trial comparing the efficacy of tropisetron plus dexamethasone (TROPDEX) vs conventional combination of metoclopramide, dexamethasone and diphenhydramine (METDEX) in prevention of acute and delayed vomiting in Chinese patients receiving high dose cisplatin.
2Thirty‐six consecutive patients with nasopharyngeal carcinoma were entered into the study, all received cisplatin at a dose range of 60–100 mg/m2. Patients were randomized in the sequence of antiemetic regimens used in two consecutive cycles.
3The TROPDEX regimen consisting of tropisetron 5 mg i.v. and dexamethasone 20 mg i.v. given on day 1 of chemotherapy, followed by oral maintenance with tropisetron 5 mg daily and dexamethasone 4 mg twice daily from day 2 to 6. The METDEX regimen consisting of metoclopramide 1 mg kg−1 i.v., dexamethasone 20 mg i.v. and diphenhydramine 25 mg i.v. given before chemotherapy and then 2 hourly for two more doses on day 1, followed by oral metoclopramide 20 mg 6 hourly from day 2 to 6.
4Complete control of acute vomiting was observed in 64% of patients with TROPDEX as compared with 14% with METDEX (P |
| doi_str_mv | 10.1046/j.1365-2125.1996.03268.x |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2042600</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>BCP326</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4976-d106664afc6b961e0c09479a99632c9063488edb6ce7299a47bbd1075dee60843</originalsourceid><addsrcrecordid>eNqNkc9u1DAQxiMEKkvhEZB84Jpg54-TIIQEK_5JlcqhnK2JM2m8SuzITre7nHiEPlkfgidh0l2t6I2Tbc33-2Y8XxQxwRPBc_l2k4hMFnEq0iIRdS0TnqWySnZPotWp8DRa8YzLuEgL8Tx6EcKGc5EJWZxFZ1WZFbISq-j-qkcGdjY44mw0w64zGvSeuY7N3k0mIB2WTcNNYC3ugGQ9BGeJCky7cQKPLbs1c08vu0WychYGRjqnBzd5GE2Lf37fPYaJbIyFRcyMZZfeEAlDYB41mq2x10ybMA2ksEz3OLq5Rw_T_h0D5sG2bjS_qLH2LgS3RU_TGhheRs86csFXx_M8-vnl89X6W3xx-fX7-uNFrPO6lHEruJQyh07LppYCueZ1XtZAm8xSXXOZ5VWFbSM1lmldQ142DTFl0SJKXuXZefTh4DvdNCO2mob3MKjJmxH8Xjkw6nHFml5du61KeZ5KzsmgOhg8fMBjd2IFV0vEaqOWJNWSpFoiVg8Rqx2hr__tfQKPmVL9zbEOQcPQ0bZolSdZxqu0KiTJ3h9kt2bA_X-3V5_WP-iW_QWmxcu7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide‐dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>CHUA, D. T. T. ; SHAM, J. S. T. ; AU, G. K. H. ; CHOY, D. ; KWONG, D. L. W. ; YAU, C. C. ; CHENG, A. C. K.</creator><creatorcontrib>CHUA, D. T. T. ; SHAM, J. S. T. ; AU, G. K. H. ; CHOY, D. ; KWONG, D. L. W. ; YAU, C. C. ; CHENG, A. C. K.</creatorcontrib><description>1We report a single‐blind randomized crossover trial comparing the efficacy of tropisetron plus dexamethasone (TROPDEX) vs conventional combination of metoclopramide, dexamethasone and diphenhydramine (METDEX) in prevention of acute and delayed vomiting in Chinese patients receiving high dose cisplatin.
2Thirty‐six consecutive patients with nasopharyngeal carcinoma were entered into the study, all received cisplatin at a dose range of 60–100 mg/m2. Patients were randomized in the sequence of antiemetic regimens used in two consecutive cycles.
3The TROPDEX regimen consisting of tropisetron 5 mg i.v. and dexamethasone 20 mg i.v. given on day 1 of chemotherapy, followed by oral maintenance with tropisetron 5 mg daily and dexamethasone 4 mg twice daily from day 2 to 6. The METDEX regimen consisting of metoclopramide 1 mg kg−1 i.v., dexamethasone 20 mg i.v. and diphenhydramine 25 mg i.v. given before chemotherapy and then 2 hourly for two more doses on day 1, followed by oral metoclopramide 20 mg 6 hourly from day 2 to 6.
4Complete control of acute vomiting was observed in 64% of patients with TROPDEX as compared with 14% with METDEX (P<0.01). While complete plus major control of acute vomiting was observed in 84% with TROPDEX as compared with 58% with METDEX. The mean vomiting episodes on day 1 were 1.4 with TROPDEX as compared with 3.5 with METDEX (P<0.01). There was, however, no significant difference between the two regimens in the control of delayed vomiting.
5When patients randomized to TROPDEX in the second cycle were compared with those with TROPDEX in the first cycle, the antiemetic efficacy was reduced, with mean acute vomiting episodes of 2 in the former compared with 0.8 in the latter (P<0.01).
6The most common adverse effect observed was headache in TROPDEX (27%) and dizziness in METDEX (40%).
7In conclusion, the antiemetic regimen TROPDEX is effective in Chinese patients receiving high dose cisplatin chemotherapy and is well tolerated. It is better than conventional METDEX regimen in the control of acute vomiting, but not in the control of delayed vomiting.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1046/j.1365-2125.1996.03268.x</identifier><identifier>PMID: 8735681</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford: Blackwell Science Ltd</publisher><subject>antiemesis ; Antiemetics - therapeutic use ; Antineoplastic Agents - adverse effects ; Asian Continental Ancestry Group ; Biological and medical sciences ; Chinese ; cisplatin ; Cisplatin - adverse effects ; Cross-Over Studies ; dexamethasone ; Dexamethasone - therapeutic use ; Digestive system ; Diphenhydramine - therapeutic use ; Drug Therapy, Combination ; Female ; Hong Kong ; Humans ; Indoles - therapeutic use ; Male ; Medical sciences ; metoclopramide ; Metoclopramide - therapeutic use ; Middle Aged ; Nasopharyngeal Neoplasms - drug therapy ; Original ; Pharmacology. Drug treatments ; Single-Blind Method ; Tropisetron ; Vomiting - chemically induced ; Vomiting - prevention & control</subject><ispartof>British journal of clinical pharmacology, 1996-05, Vol.41 (5), p.403-408</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4976-d106664afc6b961e0c09479a99632c9063488edb6ce7299a47bbd1075dee60843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,309,310,314,780,784,789,790,885,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3082856$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8735681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHUA, D. T. T.</creatorcontrib><creatorcontrib>SHAM, J. S. T.</creatorcontrib><creatorcontrib>AU, G. K. H.</creatorcontrib><creatorcontrib>CHOY, D.</creatorcontrib><creatorcontrib>KWONG, D. L. W.</creatorcontrib><creatorcontrib>YAU, C. C.</creatorcontrib><creatorcontrib>CHENG, A. C. K.</creatorcontrib><title>The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide‐dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>1We report a single‐blind randomized crossover trial comparing the efficacy of tropisetron plus dexamethasone (TROPDEX) vs conventional combination of metoclopramide, dexamethasone and diphenhydramine (METDEX) in prevention of acute and delayed vomiting in Chinese patients receiving high dose cisplatin.
2Thirty‐six consecutive patients with nasopharyngeal carcinoma were entered into the study, all received cisplatin at a dose range of 60–100 mg/m2. Patients were randomized in the sequence of antiemetic regimens used in two consecutive cycles.
3The TROPDEX regimen consisting of tropisetron 5 mg i.v. and dexamethasone 20 mg i.v. given on day 1 of chemotherapy, followed by oral maintenance with tropisetron 5 mg daily and dexamethasone 4 mg twice daily from day 2 to 6. The METDEX regimen consisting of metoclopramide 1 mg kg−1 i.v., dexamethasone 20 mg i.v. and diphenhydramine 25 mg i.v. given before chemotherapy and then 2 hourly for two more doses on day 1, followed by oral metoclopramide 20 mg 6 hourly from day 2 to 6.
4Complete control of acute vomiting was observed in 64% of patients with TROPDEX as compared with 14% with METDEX (P<0.01). While complete plus major control of acute vomiting was observed in 84% with TROPDEX as compared with 58% with METDEX. The mean vomiting episodes on day 1 were 1.4 with TROPDEX as compared with 3.5 with METDEX (P<0.01). There was, however, no significant difference between the two regimens in the control of delayed vomiting.
5When patients randomized to TROPDEX in the second cycle were compared with those with TROPDEX in the first cycle, the antiemetic efficacy was reduced, with mean acute vomiting episodes of 2 in the former compared with 0.8 in the latter (P<0.01).
6The most common adverse effect observed was headache in TROPDEX (27%) and dizziness in METDEX (40%).
7In conclusion, the antiemetic regimen TROPDEX is effective in Chinese patients receiving high dose cisplatin chemotherapy and is well tolerated. It is better than conventional METDEX regimen in the control of acute vomiting, but not in the control of delayed vomiting.</description><subject>antiemesis</subject><subject>Antiemetics - therapeutic use</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Chinese</subject><subject>cisplatin</subject><subject>Cisplatin - adverse effects</subject><subject>Cross-Over Studies</subject><subject>dexamethasone</subject><subject>Dexamethasone - therapeutic use</subject><subject>Digestive system</subject><subject>Diphenhydramine - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Hong Kong</subject><subject>Humans</subject><subject>Indoles - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metoclopramide</subject><subject>Metoclopramide - therapeutic use</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Neoplasms - drug therapy</subject><subject>Original</subject><subject>Pharmacology. Drug treatments</subject><subject>Single-Blind Method</subject><subject>Tropisetron</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - prevention & control</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxiMEKkvhEZB84Jpg54-TIIQEK_5JlcqhnK2JM2m8SuzITre7nHiEPlkfgidh0l2t6I2Tbc33-2Y8XxQxwRPBc_l2k4hMFnEq0iIRdS0TnqWySnZPotWp8DRa8YzLuEgL8Tx6EcKGc5EJWZxFZ1WZFbISq-j-qkcGdjY44mw0w64zGvSeuY7N3k0mIB2WTcNNYC3ugGQ9BGeJCky7cQKPLbs1c08vu0WychYGRjqnBzd5GE2Lf37fPYaJbIyFRcyMZZfeEAlDYB41mq2x10ybMA2ksEz3OLq5Rw_T_h0D5sG2bjS_qLH2LgS3RU_TGhheRs86csFXx_M8-vnl89X6W3xx-fX7-uNFrPO6lHEruJQyh07LppYCueZ1XtZAm8xSXXOZ5VWFbSM1lmldQ142DTFl0SJKXuXZefTh4DvdNCO2mob3MKjJmxH8Xjkw6nHFml5du61KeZ5KzsmgOhg8fMBjd2IFV0vEaqOWJNWSpFoiVg8Rqx2hr__tfQKPmVL9zbEOQcPQ0bZolSdZxqu0KiTJ3h9kt2bA_X-3V5_WP-iW_QWmxcu7</recordid><startdate>199605</startdate><enddate>199605</enddate><creator>CHUA, D. T. T.</creator><creator>SHAM, J. S. T.</creator><creator>AU, G. K. H.</creator><creator>CHOY, D.</creator><creator>KWONG, D. L. W.</creator><creator>YAU, C. C.</creator><creator>CHENG, A. C. K.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>199605</creationdate><title>The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide‐dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial</title><author>CHUA, D. T. T. ; SHAM, J. S. T. ; AU, G. K. H. ; CHOY, D. ; KWONG, D. L. W. ; YAU, C. C. ; CHENG, A. C. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4976-d106664afc6b961e0c09479a99632c9063488edb6ce7299a47bbd1075dee60843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>antiemesis</topic><topic>Antiemetics - therapeutic use</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Chinese</topic><topic>cisplatin</topic><topic>Cisplatin - adverse effects</topic><topic>Cross-Over Studies</topic><topic>dexamethasone</topic><topic>Dexamethasone - therapeutic use</topic><topic>Digestive system</topic><topic>Diphenhydramine - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Hong Kong</topic><topic>Humans</topic><topic>Indoles - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metoclopramide</topic><topic>Metoclopramide - therapeutic use</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Neoplasms - drug therapy</topic><topic>Original</topic><topic>Pharmacology. Drug treatments</topic><topic>Single-Blind Method</topic><topic>Tropisetron</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHUA, D. T. T.</creatorcontrib><creatorcontrib>SHAM, J. S. T.</creatorcontrib><creatorcontrib>AU, G. K. H.</creatorcontrib><creatorcontrib>CHOY, D.</creatorcontrib><creatorcontrib>KWONG, D. L. W.</creatorcontrib><creatorcontrib>YAU, C. C.</creatorcontrib><creatorcontrib>CHENG, A. C. K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHUA, D. T. T.</au><au>SHAM, J. S. T.</au><au>AU, G. K. H.</au><au>CHOY, D.</au><au>KWONG, D. L. W.</au><au>YAU, C. C.</au><au>CHENG, A. C. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide‐dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1996-05</date><risdate>1996</risdate><volume>41</volume><issue>5</issue><spage>403</spage><epage>408</epage><pages>403-408</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>1We report a single‐blind randomized crossover trial comparing the efficacy of tropisetron plus dexamethasone (TROPDEX) vs conventional combination of metoclopramide, dexamethasone and diphenhydramine (METDEX) in prevention of acute and delayed vomiting in Chinese patients receiving high dose cisplatin.
2Thirty‐six consecutive patients with nasopharyngeal carcinoma were entered into the study, all received cisplatin at a dose range of 60–100 mg/m2. Patients were randomized in the sequence of antiemetic regimens used in two consecutive cycles.
3The TROPDEX regimen consisting of tropisetron 5 mg i.v. and dexamethasone 20 mg i.v. given on day 1 of chemotherapy, followed by oral maintenance with tropisetron 5 mg daily and dexamethasone 4 mg twice daily from day 2 to 6. The METDEX regimen consisting of metoclopramide 1 mg kg−1 i.v., dexamethasone 20 mg i.v. and diphenhydramine 25 mg i.v. given before chemotherapy and then 2 hourly for two more doses on day 1, followed by oral metoclopramide 20 mg 6 hourly from day 2 to 6.
4Complete control of acute vomiting was observed in 64% of patients with TROPDEX as compared with 14% with METDEX (P<0.01). While complete plus major control of acute vomiting was observed in 84% with TROPDEX as compared with 58% with METDEX. The mean vomiting episodes on day 1 were 1.4 with TROPDEX as compared with 3.5 with METDEX (P<0.01). There was, however, no significant difference between the two regimens in the control of delayed vomiting.
5When patients randomized to TROPDEX in the second cycle were compared with those with TROPDEX in the first cycle, the antiemetic efficacy was reduced, with mean acute vomiting episodes of 2 in the former compared with 0.8 in the latter (P<0.01).
6The most common adverse effect observed was headache in TROPDEX (27%) and dizziness in METDEX (40%).
7In conclusion, the antiemetic regimen TROPDEX is effective in Chinese patients receiving high dose cisplatin chemotherapy and is well tolerated. It is better than conventional METDEX regimen in the control of acute vomiting, but not in the control of delayed vomiting.</abstract><cop>Oxford</cop><pub>Blackwell Science Ltd</pub><pmid>8735681</pmid><doi>10.1046/j.1365-2125.1996.03268.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1996-05, Vol.41 (5), p.403-408 |
| issn | 0306-5251 1365-2125 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2042600 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | antiemesis Antiemetics - therapeutic use Antineoplastic Agents - adverse effects Asian Continental Ancestry Group Biological and medical sciences Chinese cisplatin Cisplatin - adverse effects Cross-Over Studies dexamethasone Dexamethasone - therapeutic use Digestive system Diphenhydramine - therapeutic use Drug Therapy, Combination Female Hong Kong Humans Indoles - therapeutic use Male Medical sciences metoclopramide Metoclopramide - therapeutic use Middle Aged Nasopharyngeal Neoplasms - drug therapy Original Pharmacology. Drug treatments Single-Blind Method Tropisetron Vomiting - chemically induced Vomiting - prevention & control |
| title | The antiemetic efficacy of tropisetron plus dexamethasone as compared with conventional metoclopramide‐dexamethasone combination in Orientals receiving cisplatin chemotherapy: a randomized crossover trial |
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