Role of macrophage migration inhibitory factor (MIF) in peripheral nerve regeneration: anti-MIF antibody induces delay of nerve regeneration and the apoptosis of Schwann cells

Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine involved in inflammation and immune responses as well as in cell growth. Although we previously demonstrated the presence of MIF in peripheral nerves, and MIF mRNA expression was up-regulated after axotomy, the role of MIF in ner...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 2002-09, Vol.8 (9), p.509-520
Hauptverfasser:	Nishio, Yasuhiko, Nishihira, Jun, Ishibashi, Teruo, Kato, Hiroyuki, Minami, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Apoptosis - immunology Axons - physiology Immunohistochemistry In Situ Nick-End Labeling Macrophage Migration-Inhibitory Factors - immunology Macrophage Migration-Inhibitory Factors - physiology Macrophages - physiology Male Nerve Regeneration - physiology Peripheral Nerves - physiology Rats Rats, Wistar Schwann Cells - immunology Schwann Cells - physiology Staining and Labeling T-Lymphocytes - physiology
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