Molecular genetic evidence for unifocal origin of advanced epithelial ovarian cancer and for minor clonal divergence

Detection of loss of heterozygosity (LOH) and DNA flow cytometry (FCM) were used to trace the origin of bilateral ovarian cancer from 16 patients. From each tumour the DNA index (DI) and LOH patterns for chromosomes 1, 3, 6, 11, 17, 18, 22 and X were determined with 36 microsatellite markers. Formal...

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Veröffentlicht in:	British journal of cancer 1995-11, Vol.72 (5), p.1330-1336
Hauptverfasser:	ABELN, E. C. A, KUIPERS-DIJKSHOORN, N. J, BERNS, E. M. J. J, HENZEN-LOGMANS, S. C, FLEUREN, G. J, CORNELISSE, C. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma - genetics Carcinoma - pathology Carcinoma - secondary Clone Cells DNA Mutational Analysis DNA, Neoplasm - analysis Epithelium - chemistry Epithelium - pathology Female Female genital diseases Flow Cytometry Frozen Sections Gene Deletion Genetic Markers Gynecology. Andrology. Obstetrics Humans Medical sciences Microsatellite Repeats Neoplasm Metastasis Neoplasms, Multiple Primary - genetics Neoplasms, Multiple Primary - pathology Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Ovarian Neoplasms - secondary Paraffin Embedding Polymerase Chain Reaction Tumors
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