The interaction with tubulin of a series of stilbenes based on combretastatin A-4

A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-...

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Veröffentlicht in:	British journal of cancer 1995-04, Vol.71 (4), p.705-711
Hauptverfasser:	Woods, JA, Hadfield, JA, Pettit, GR, Fox, BW, McGown, AT
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - toxicity Binding, Competitive Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Cycle - drug effects Drug Resistance Epidemiology experimental-oncology General aspects Leukemia P388 Medical sciences Mice Microtubules - drug effects Microtubules - ultrastructure Mitotic Index - drug effects Molecular Medicine Molecular Structure Oncology Pharmacology. Drug treatments Stilbenes - chemical synthesis Stilbenes - chemistry Stilbenes - toxicity Structure-Activity Relationship Thermodynamics Tubulin - chemistry Tumor Cells, Cultured
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