Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells

Adhesion of parasite‐infected red blood cells to the vascular endothelium is a critical event in the pathogenesis of malaria caused by Plasmodium falciparum . Adherence is mediated by the variant erythrocyte membrane protein 1 (PfEMP1). Another protein, erythrocyte membrane protein‐3 (PfEMP3), is de...

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Veröffentlicht in:	The EMBO journal 2000-06, Vol.19 (12), p.2813-2823
Hauptverfasser:	Waterkeyn, Jacqueline G., Wickham, Mark E., Davern, Kathleen M., Cooke, Brian M., Coppel, Ross L., Reeder, John C., Culvenor, Janetta G., Waller, Ross F., Cowman, Alan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport CD36 Antigens - metabolism Cell Adhesion Cell Compartmentation Cell Polarity cytoadherence EMP3 protein Endothelium, Vascular - parasitology Erythrocyte Membrane - parasitology Erythrocyte Membrane - ultrastructure erythrocyte membrane protein 3 Erythrocytes Genes, Protozoan Malaria Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Mutagenesis Parasites Peptides - metabolism PfEMP1 PfEMP3 Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - ultrastructure protein trafficking Protozoan Proteins - metabolism Recombinant Proteins - biosynthesis Vector-borne diseases
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