Effects of antithrombotic agents evaluated in a nonhuman primate vascular shunt model
The effects of aspirin, cyproheptadine, dextran, dipyridamole, and sulfinpyrazone on thrombus deposition were determined. These antithrombotic agents were evaluated in a nonhuman primate model for thrombus generation that employed test devices exposed to blood in an arteriovenous shunt. Thrombus dep...
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| Veröffentlicht in: | The American journal of pathology 1976-06, Vol.83 (3), p.557-568 |
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| container_title | The American journal of pathology |
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| creator | Mason, RG Wolf, RH Zucker, WH Shinoda, BA Mohammad, SF |
| description | The effects of aspirin, cyproheptadine, dextran, dipyridamole, and sulfinpyrazone on thrombus deposition were determined. These antithrombotic agents were evaluated in a nonhuman primate model for thrombus generation that employed test devices exposed to blood in an arteriovenous shunt. Thrombus deposition on test devices was quantitated gravimetrically. Of the antithrombotic agents tested, cyproheptadine was found to be the most effective, and aspirin, dextran, and dipyridamole were each somewhat less effective. Sulfinpyrazone had only a slight antithrombotic effect. Ultrastructual studies of thrombus deposited in test devices showed that the various antithrombotic agents tested did not prevent completely the formation of fibrin, aggregation of platelets, or adhesion and spreading of platelets and leukocytes. This model for thrombus generation is felt to be a more efficient means for evaluating antithrombotic agents than previously described nonhuman primate models. |
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These antithrombotic agents were evaluated in a nonhuman primate model for thrombus generation that employed test devices exposed to blood in an arteriovenous shunt. Thrombus deposition on test devices was quantitated gravimetrically. Of the antithrombotic agents tested, cyproheptadine was found to be the most effective, and aspirin, dextran, and dipyridamole were each somewhat less effective. Sulfinpyrazone had only a slight antithrombotic effect. Ultrastructual studies of thrombus deposited in test devices showed that the various antithrombotic agents tested did not prevent completely the formation of fibrin, aggregation of platelets, or adhesion and spreading of platelets and leukocytes. This model for thrombus generation is felt to be a more efficient means for evaluating antithrombotic agents than previously described nonhuman primate models.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>PMID: 820202</identifier><language>eng</language><publisher>United States: ASIP</publisher><subject>Animals ; Arteriovenous Shunt, Surgical ; Disease Models, Animal ; Fibrinolytic Agents - therapeutic use ; Haplorhini ; Macaca mulatta ; Thrombosis - blood ; Thrombosis - drug therapy ; Thrombosis - pathology</subject><ispartof>The American journal of pathology, 1976-06, Vol.83 (3), p.557-568</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032506/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032506/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/820202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mason, RG</creatorcontrib><creatorcontrib>Wolf, RH</creatorcontrib><creatorcontrib>Zucker, WH</creatorcontrib><creatorcontrib>Shinoda, BA</creatorcontrib><creatorcontrib>Mohammad, SF</creatorcontrib><title>Effects of antithrombotic agents evaluated in a nonhuman primate vascular shunt model</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>The effects of aspirin, cyproheptadine, dextran, dipyridamole, and sulfinpyrazone on thrombus deposition were determined. These antithrombotic agents were evaluated in a nonhuman primate model for thrombus generation that employed test devices exposed to blood in an arteriovenous shunt. Thrombus deposition on test devices was quantitated gravimetrically. Of the antithrombotic agents tested, cyproheptadine was found to be the most effective, and aspirin, dextran, and dipyridamole were each somewhat less effective. Sulfinpyrazone had only a slight antithrombotic effect. Ultrastructual studies of thrombus deposited in test devices showed that the various antithrombotic agents tested did not prevent completely the formation of fibrin, aggregation of platelets, or adhesion and spreading of platelets and leukocytes. This model for thrombus generation is felt to be a more efficient means for evaluating antithrombotic agents than previously described nonhuman primate models.</description><subject>Animals</subject><subject>Arteriovenous Shunt, Surgical</subject><subject>Disease Models, Animal</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Haplorhini</subject><subject>Macaca mulatta</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - drug therapy</subject><subject>Thrombosis - pathology</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUMtqwzAQFKWvNO0f9KBLezPoZVu-FEpIHxDopTkLWV7HCrKUWnZK_76iCaVlD8vuDDPDnKAZzVmeMVrRUzQjhLCsEoJcoqsYt-ksuCQX6FwykmaG1su2BTNGHFqs_WjHbgh9HUZrsN6ATwDstZv0CA22Hmvsg--mXnu8G2yf3nivo5mcHnDsJj_iPjTgrtFZq12Em-Oeo_XT8n3xkq3enl8Xj6usYxUZs5JUWkhD6qKkUNYNYabhvDbSFBKobKWopABSNCIvylKYRrQVBUIh58BryvgcPRx0d1PdQ2NS4EE79RNt-FJBW_Uf8bZTm7BXjHCWpy7m6P4oMISPCeKoehsNOKc9hCkqyQUvpSgT8fav06_FoccE3x3gzm66TzuAir12LpGp0tud5IqrPC_5N4Axfno</recordid><startdate>19760601</startdate><enddate>19760601</enddate><creator>Mason, RG</creator><creator>Wolf, RH</creator><creator>Zucker, WH</creator><creator>Shinoda, BA</creator><creator>Mohammad, SF</creator><general>ASIP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19760601</creationdate><title>Effects of antithrombotic agents evaluated in a nonhuman primate vascular shunt model</title><author>Mason, RG ; Wolf, RH ; Zucker, WH ; Shinoda, BA ; Mohammad, SF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h290t-709a48c0b671e7bd02cd33bc8c68e18f84984e06d456774cd4f91e01e53e3b123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Animals</topic><topic>Arteriovenous Shunt, Surgical</topic><topic>Disease Models, Animal</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Haplorhini</topic><topic>Macaca mulatta</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - drug therapy</topic><topic>Thrombosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mason, RG</creatorcontrib><creatorcontrib>Wolf, RH</creatorcontrib><creatorcontrib>Zucker, WH</creatorcontrib><creatorcontrib>Shinoda, BA</creatorcontrib><creatorcontrib>Mohammad, SF</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mason, RG</au><au>Wolf, RH</au><au>Zucker, WH</au><au>Shinoda, BA</au><au>Mohammad, SF</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of antithrombotic agents evaluated in a nonhuman primate vascular shunt model</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1976-06-01</date><risdate>1976</risdate><volume>83</volume><issue>3</issue><spage>557</spage><epage>568</epage><pages>557-568</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><abstract>The effects of aspirin, cyproheptadine, dextran, dipyridamole, and sulfinpyrazone on thrombus deposition were determined. These antithrombotic agents were evaluated in a nonhuman primate model for thrombus generation that employed test devices exposed to blood in an arteriovenous shunt. Thrombus deposition on test devices was quantitated gravimetrically. Of the antithrombotic agents tested, cyproheptadine was found to be the most effective, and aspirin, dextran, and dipyridamole were each somewhat less effective. Sulfinpyrazone had only a slight antithrombotic effect. Ultrastructual studies of thrombus deposited in test devices showed that the various antithrombotic agents tested did not prevent completely the formation of fibrin, aggregation of platelets, or adhesion and spreading of platelets and leukocytes. This model for thrombus generation is felt to be a more efficient means for evaluating antithrombotic agents than previously described nonhuman primate models.</abstract><cop>United States</cop><pub>ASIP</pub><pmid>820202</pmid><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0002-9440 |
| ispartof | The American journal of pathology, 1976-06, Vol.83 (3), p.557-568 |
| issn | 0002-9440 1525-2191 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Arteriovenous Shunt, Surgical Disease Models, Animal Fibrinolytic Agents - therapeutic use Haplorhini Macaca mulatta Thrombosis - blood Thrombosis - drug therapy Thrombosis - pathology |
| title | Effects of antithrombotic agents evaluated in a nonhuman primate vascular shunt model |
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