Mitochondrial Decay in Hepatocytes from Old Rats: Membrane Potential Declines, Heterogeneity and Oxidants Increase

Mitochondrial function during aging was assessed in isolated rat hepatocytes to avoid the problem of differential lysis when old, fragile mitochondria are isolated. Rhodamine 123, a fluorescent dye that accumulates in mitochondria on the basis of their membrane potential, was used as a probe to dete...

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