Radiation-induced erythroleukemia in the beagle dog. A hematologic summary of five cases
Eleven cases of myeloproliferative disease occurred in a group of 24 beagle dogs placed in a 60Co gamma-ray field at about 13 months of age and irradiated at an exposure rate of 5 R/22-hour day for duratior of life. Of these 11 dogs, 5 (described in this paper) were diagnosed as having erythroleukem...
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| Veröffentlicht in: | The American journal of pathology 1977-06, Vol.87 (3), p.499-510 |
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| creator | Tolle, DV Fritz, TE Norris, WP |
| description | Eleven cases of myeloproliferative disease occurred in a group of 24 beagle dogs placed in a 60Co gamma-ray field at about 13 months of age and irradiated at an exposure rate of 5 R/22-hour day for duratior of life. Of these 11 dogs, 5 (described in this paper) were diagnosed as having erythroleukemia. The bone marrow showed marked erythroblastic hyperplasia, with maturation arrest of the erythroid elements, and increased numbers of myeloblasts and promyelocytes. The terminal peripheral blood was characterized by marked anemia and thrombocytopenia, with circulating erythrocytic precursors and abnormal erythrocyte morphology. Splenomegaly and hepatomegaly occurred in 4 of the 5 animals. In the spleens and livers of all 5, there was extensive leukemic infiltration and proliferation. The extent of leukemic involvement in other tissues and organs varied in individual dogs. |
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In the spleens and livers of all 5, there was extensive leukemic infiltration and proliferation. The extent of leukemic involvement in other tissues and organs varied in individual dogs.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>PMID: 266846</identifier><language>eng</language><publisher>United States: ASIP</publisher><subject>Animals ; Bone Marrow - pathology ; Bone Marrow - radiation effects ; Cobalt Radioisotopes - adverse effects ; Disease Models, Animal ; Dog Diseases - etiology ; Dogs ; Erythrocytes - pathology ; Erythrocytes, Abnormal - radiation effects ; Female ; Leukemia, Erythroblastic, Acute - blood ; Leukemia, Erythroblastic, Acute - etiology ; Liver - pathology ; Liver - radiation effects ; Male ; Radiation Effects ; Spleen - pathology ; Spleen - radiation effects</subject><ispartof>The American journal of pathology, 1977-06, Vol.87 (3), p.499-510</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032130/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032130/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/266846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolle, DV</creatorcontrib><creatorcontrib>Fritz, TE</creatorcontrib><creatorcontrib>Norris, WP</creatorcontrib><title>Radiation-induced erythroleukemia in the beagle dog. 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The extent of leukemic involvement in other tissues and organs varied in individual dogs.</description><subject>Animals</subject><subject>Bone Marrow - pathology</subject><subject>Bone Marrow - radiation effects</subject><subject>Cobalt Radioisotopes - adverse effects</subject><subject>Disease Models, Animal</subject><subject>Dog Diseases - etiology</subject><subject>Dogs</subject><subject>Erythrocytes - pathology</subject><subject>Erythrocytes, Abnormal - radiation effects</subject><subject>Female</subject><subject>Leukemia, Erythroblastic, Acute - blood</subject><subject>Leukemia, Erythroblastic, Acute - etiology</subject><subject>Liver - pathology</subject><subject>Liver - radiation effects</subject><subject>Male</subject><subject>Radiation Effects</subject><subject>Spleen - pathology</subject><subject>Spleen - radiation effects</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtKxEAQRRvxNY7-gYveuIz0K5nujTAMvkAQRMFdU52uJD0m6SGPkfl7IyOiq6I4tw6XOiAznoo0EdzwQzJjjInEKMVOyVnfr6c1k5qdkGORZVplM_L-Aj7AEGKbhNaPOXqK3W6ouljj-IFNABpaOlRIHUJZI_WxvKZLWmEDQ6xjGXLaj00D3Y7GghZhizSHHvtzclRA3ePFz5yTt7vb19VD8vR8_7haPiWVYOmQOJfBQvtC5MzkXIJMjdPOaeGk0s5IvvCqmFozLpArwzVP0akCpRfAFqjknNzsvZvRNehzbIcOarvpwncnGyHY_6QNlS3j1gomBZdsElz-Ffxe7j804as9rkJZfYYObd9AXU9hbmG90QsrrTJGfgEWkXGz</recordid><startdate>19770601</startdate><enddate>19770601</enddate><creator>Tolle, DV</creator><creator>Fritz, TE</creator><creator>Norris, WP</creator><general>ASIP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>19770601</creationdate><title>Radiation-induced erythroleukemia in the beagle dog. 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A hematologic summary of five cases</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1977-06-01</date><risdate>1977</risdate><volume>87</volume><issue>3</issue><spage>499</spage><epage>510</epage><pages>499-510</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><abstract>Eleven cases of myeloproliferative disease occurred in a group of 24 beagle dogs placed in a 60Co gamma-ray field at about 13 months of age and irradiated at an exposure rate of 5 R/22-hour day for duratior of life. Of these 11 dogs, 5 (described in this paper) were diagnosed as having erythroleukemia. The bone marrow showed marked erythroblastic hyperplasia, with maturation arrest of the erythroid elements, and increased numbers of myeloblasts and promyelocytes. The terminal peripheral blood was characterized by marked anemia and thrombocytopenia, with circulating erythrocytic precursors and abnormal erythrocyte morphology. 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| ispartof | The American journal of pathology, 1977-06, Vol.87 (3), p.499-510 |
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| subjects | Animals Bone Marrow - pathology Bone Marrow - radiation effects Cobalt Radioisotopes - adverse effects Disease Models, Animal Dog Diseases - etiology Dogs Erythrocytes - pathology Erythrocytes, Abnormal - radiation effects Female Leukemia, Erythroblastic, Acute - blood Leukemia, Erythroblastic, Acute - etiology Liver - pathology Liver - radiation effects Male Radiation Effects Spleen - pathology Spleen - radiation effects |
| title | Radiation-induced erythroleukemia in the beagle dog. A hematologic summary of five cases |
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