Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2+-permeability

RNA editing modifies the GluR2 AMPA receptor subunit pore loop at the Q/R site and limits receptor Ca(2+) permeability. Editing failure is implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis. We show that channels with unedited GluR2 are highly toxic in cultured hippoca...

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Veröffentlicht in:	Molecular and cellular neuroscience 2007-07, Vol.35 (3), p.470-481
Hauptverfasser:	Mahajan, S S, Ziff, E B
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - toxicity Animals Calcium - metabolism Cell Death - drug effects Dose-Response Relationship, Drug Embryo, Mammalian Excitatory Amino Acid Agonists - pharmacology Hippocampus - cytology In Situ Nick-End Labeling - methods Mutagenesis - physiology Neurons - drug effects Neurons - metabolism Permeability - drug effects Protein Transport - drug effects Protein Transport - physiology Rats Rats, Sprague-Dawley Receptors, AMPA - genetics Receptors, AMPA - metabolism Sindbis Virus - physiology Time Factors Transcriptional Activation
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