PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake
Positron emission tomography (PET) attenuation correction (AC) using computed tomography (CT) can be affected by respiratory motion: hi-speed CT captures 1 point of the respiratory cycle while PET emission data averages many cycles. We quantified the changes in apparent myocardial uptake due to this...
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| Veröffentlicht in: | Journal of nuclear cardiology 2006-11, Vol.13 (6), p.821-830 |
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| creator | Le Meunier, Ludovic Maass-Moreno, Roberto Carrasquillo, Jorge A. Dieckmann, William Bacharach, Stephen L. |
| description | Positron emission tomography (PET) attenuation correction (AC) using computed tomography (CT) can be affected by respiratory motion: hi-speed CT captures 1 point of the respiratory cycle while PET emission data averages many cycles. We quantified the changes in apparent myocardial uptake due to this respiratory-induced CT attenuation mismatch.
Twenty-two patients undergoing fluorine-18 fluorodexyglucose (FDG) PET/CT received 3 sequential CT scans at normal resting end-inspiration (CT
INSPIR), ending expiration (CT
EXPIR), and at midvolume between end-expiration and end-inspiration (CT
MIDVOL). A pneumotachometer measured absolute changes in lung volume. Seven subjects also underwent a 3-minute transmission scan with a
68Ge rotating rod source (RRS). The PET emission data set was reconstructed up to 4 times using CT
EXPIR, CT
INSPIR, CT
MIDVOL, and RRS AC maps. Relative heart position and cardiac uptake was measured for each CT attenuation correction.
Respiratory motion produced marked changes in global and regional myocardial uptake. Changes were large in the lateral and anterior regions at the lung-soft tissue interface (up to 30% using CT
INSPIR compared to CT
EXPIR for AC) and smaller in the septal region (10% or less). Data corrected with CT
EXPIR agreed best with the RRS.
Respiratory effects can introduce large inhomogeneities in apparent myocardial uptake when CT is used for attenuation correction. |
| doi_str_mv | 10.1016/j.nuclcard.2006.09.003 |
| format | Article |
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Twenty-two patients undergoing fluorine-18 fluorodexyglucose (FDG) PET/CT received 3 sequential CT scans at normal resting end-inspiration (CT
INSPIR), ending expiration (CT
EXPIR), and at midvolume between end-expiration and end-inspiration (CT
MIDVOL). A pneumotachometer measured absolute changes in lung volume. Seven subjects also underwent a 3-minute transmission scan with a
68Ge rotating rod source (RRS). The PET emission data set was reconstructed up to 4 times using CT
EXPIR, CT
INSPIR, CT
MIDVOL, and RRS AC maps. Relative heart position and cardiac uptake was measured for each CT attenuation correction.
Respiratory motion produced marked changes in global and regional myocardial uptake. Changes were large in the lateral and anterior regions at the lung-soft tissue interface (up to 30% using CT
INSPIR compared to CT
EXPIR for AC) and smaller in the septal region (10% or less). Data corrected with CT
EXPIR agreed best with the RRS.
Respiratory effects can introduce large inhomogeneities in apparent myocardial uptake when CT is used for attenuation correction.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1016/j.nuclcard.2006.09.003</identifier><identifier>PMID: 17174813</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Attenuation and scatter correction ; Fluorine-18 ; Fluorodeoxyglucose F18 - pharmacokinetics ; Heart - diagnostic imaging ; Humans ; Image artefacts ; Movement - physiology ; Myocardium - metabolism ; PET/CT imaging ; Positron-Emission Tomography - methods ; Radiopharmaceuticals - pharmacokinetics ; Reproducibility of Results ; Respiratory Mechanics - physiology ; Sensitivity and Specificity ; Subtraction Technique ; Tomography, X-Ray Computed - methods</subject><ispartof>Journal of nuclear cardiology, 2006-11, Vol.13 (6), p.821-830</ispartof><rights>2006 American Society of Nuclear Cardiology</rights><rights>American Society of Nuclear Cardiology 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-edda418d3dbd52b9da10fc1d55a4754989212a031a1ba32a1b3477941e4915873</citedby><cites>FETCH-LOGICAL-c496t-edda418d3dbd52b9da10fc1d55a4754989212a031a1ba32a1b3477941e4915873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17174813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Meunier, Ludovic</creatorcontrib><creatorcontrib>Maass-Moreno, Roberto</creatorcontrib><creatorcontrib>Carrasquillo, Jorge A.</creatorcontrib><creatorcontrib>Dieckmann, William</creatorcontrib><creatorcontrib>Bacharach, Stephen L.</creatorcontrib><title>PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake</title><title>Journal of nuclear cardiology</title><addtitle>J Nucl Cardiol</addtitle><description>Positron emission tomography (PET) attenuation correction (AC) using computed tomography (CT) can be affected by respiratory motion: hi-speed CT captures 1 point of the respiratory cycle while PET emission data averages many cycles. We quantified the changes in apparent myocardial uptake due to this respiratory-induced CT attenuation mismatch.
Twenty-two patients undergoing fluorine-18 fluorodexyglucose (FDG) PET/CT received 3 sequential CT scans at normal resting end-inspiration (CT
INSPIR), ending expiration (CT
EXPIR), and at midvolume between end-expiration and end-inspiration (CT
MIDVOL). A pneumotachometer measured absolute changes in lung volume. Seven subjects also underwent a 3-minute transmission scan with a
68Ge rotating rod source (RRS). The PET emission data set was reconstructed up to 4 times using CT
EXPIR, CT
INSPIR, CT
MIDVOL, and RRS AC maps. Relative heart position and cardiac uptake was measured for each CT attenuation correction.
Respiratory motion produced marked changes in global and regional myocardial uptake. Changes were large in the lateral and anterior regions at the lung-soft tissue interface (up to 30% using CT
INSPIR compared to CT
EXPIR for AC) and smaller in the septal region (10% or less). Data corrected with CT
EXPIR agreed best with the RRS.
Respiratory effects can introduce large inhomogeneities in apparent myocardial uptake when CT is used for attenuation correction.</description><subject>Adult</subject><subject>Attenuation and scatter correction</subject><subject>Fluorine-18</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Heart - diagnostic imaging</subject><subject>Humans</subject><subject>Image artefacts</subject><subject>Movement - physiology</subject><subject>Myocardium - metabolism</subject><subject>PET/CT imaging</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Reproducibility of Results</subject><subject>Respiratory Mechanics - physiology</subject><subject>Sensitivity and Specificity</subject><subject>Subtraction Technique</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkUuP0zAUhS0EYoaBvzCKWLBLxtfPmAViVJWXRoJFWVuu7RSXJA52MlL_PS4tzw2SZVvyd8-9xweha8ANYBA3-2ZcbG9Ncg3BWDRYNRjTB-gSOCW14BweljuWUFPewgV6kvMeY6yoUo_RBUiQrAV6iT58Wm9uVpsqDGYXxt3Lat113s5V7Krk8xSSmWM6VEOcQxyrssw0meTHuRoO8dg-mL5aptl89U_Ro8702T87n1fo85v1ZvWuvvv49v3q9q62TIm59s4ZBq2jbus42SpnAHcWHOeGSc5UqwgQgykY2BpKyk6ZlIqBZwp4K-kVenXSnZbt4J0twyTT6ykVD-mgown675cxfNG7eK8JplgQVQRenAVS_Lb4POshZOv73ow-LlmLlnDGfoDP_wH3cUljMaclZQKIkLRA4gTZFHNOvvs1CWB9zErv9c-s9DErjZUuWZXC6z99_C47h1OA1yfAl9-8Dz7pbIMfrXchlYy0i-F_Pb4DqOWo1g</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Le Meunier, Ludovic</creator><creator>Maass-Moreno, Roberto</creator><creator>Carrasquillo, Jorge A.</creator><creator>Dieckmann, William</creator><creator>Bacharach, Stephen L.</creator><general>Elsevier Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20061101</creationdate><title>PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake</title><author>Le Meunier, Ludovic ; Maass-Moreno, Roberto ; Carrasquillo, Jorge A. ; Dieckmann, William ; Bacharach, Stephen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-edda418d3dbd52b9da10fc1d55a4754989212a031a1ba32a1b3477941e4915873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Attenuation and scatter correction</topic><topic>Fluorine-18</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Heart - diagnostic imaging</topic><topic>Humans</topic><topic>Image artefacts</topic><topic>Movement - physiology</topic><topic>Myocardium - metabolism</topic><topic>PET/CT imaging</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Reproducibility of Results</topic><topic>Respiratory Mechanics - physiology</topic><topic>Sensitivity and Specificity</topic><topic>Subtraction Technique</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Meunier, Ludovic</creatorcontrib><creatorcontrib>Maass-Moreno, Roberto</creatorcontrib><creatorcontrib>Carrasquillo, Jorge A.</creatorcontrib><creatorcontrib>Dieckmann, William</creatorcontrib><creatorcontrib>Bacharach, Stephen L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Meunier, Ludovic</au><au>Maass-Moreno, Roberto</au><au>Carrasquillo, Jorge A.</au><au>Dieckmann, William</au><au>Bacharach, Stephen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake</atitle><jtitle>Journal of nuclear cardiology</jtitle><addtitle>J Nucl Cardiol</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>13</volume><issue>6</issue><spage>821</spage><epage>830</epage><pages>821-830</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Positron emission tomography (PET) attenuation correction (AC) using computed tomography (CT) can be affected by respiratory motion: hi-speed CT captures 1 point of the respiratory cycle while PET emission data averages many cycles. We quantified the changes in apparent myocardial uptake due to this respiratory-induced CT attenuation mismatch.
Twenty-two patients undergoing fluorine-18 fluorodexyglucose (FDG) PET/CT received 3 sequential CT scans at normal resting end-inspiration (CT
INSPIR), ending expiration (CT
EXPIR), and at midvolume between end-expiration and end-inspiration (CT
MIDVOL). A pneumotachometer measured absolute changes in lung volume. Seven subjects also underwent a 3-minute transmission scan with a
68Ge rotating rod source (RRS). The PET emission data set was reconstructed up to 4 times using CT
EXPIR, CT
INSPIR, CT
MIDVOL, and RRS AC maps. Relative heart position and cardiac uptake was measured for each CT attenuation correction.
Respiratory motion produced marked changes in global and regional myocardial uptake. Changes were large in the lateral and anterior regions at the lung-soft tissue interface (up to 30% using CT
INSPIR compared to CT
EXPIR for AC) and smaller in the septal region (10% or less). Data corrected with CT
EXPIR agreed best with the RRS.
Respiratory effects can introduce large inhomogeneities in apparent myocardial uptake when CT is used for attenuation correction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17174813</pmid><doi>10.1016/j.nuclcard.2006.09.003</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1071-3581 |
| ispartof | Journal of nuclear cardiology, 2006-11, Vol.13 (6), p.821-830 |
| issn | 1071-3581 1532-6551 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2030629 |
| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Adult Attenuation and scatter correction Fluorine-18 Fluorodeoxyglucose F18 - pharmacokinetics Heart - diagnostic imaging Humans Image artefacts Movement - physiology Myocardium - metabolism PET/CT imaging Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics Reproducibility of Results Respiratory Mechanics - physiology Sensitivity and Specificity Subtraction Technique Tomography, X-Ray Computed - methods |
| title | PET/CT imaging: Effect of respiratory motion on apparent myocardial uptake |
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