ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

The discovery of the ABCA1 lipid transporter has generated interest in modulating human plasma HDL levels and atherogenic risk by enhancing ABCA1 gene expression. To determine if increased ABCA1 expression modulates HDL metabolism in vivo, we generated transgenic mice that overexpress human ABCA1 (h...

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Veröffentlicht in:	The Journal of clinical investigation 2001-07, Vol.108 (2), p.303-309
Hauptverfasser:	Vaisman, B L, Lambert, G, Amar, M, Joyce, C, Ito, T, Shamburek, R D, Cain, W J, Fruchart-Najib, J, Neufeld, E D, Remaley, A T, Brewer, Jr, H B, Santamarina-Fojo, S
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 gene Animals Apolipoproteins - blood ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - metabolism Bile - chemistry Bile - metabolism Cholesterol - analysis Cholesterol - metabolism Gene Expression Regulation Humans Hyperlipoproteinemias - blood Hyperlipoproteinemias - etiology Hyperlipoproteinemias - metabolism Lipids - blood Lipoproteins, HDL - blood Lipoproteins, HDL - metabolism Lipoproteins, VLDL - metabolism Liver - metabolism Macrophages - metabolism Mice Mice, Transgenic
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