Serum immunoglobulin levels in primary liver cancer: relationship to underlying cirrhosis and hepatitis-B (surface) antigenaemia
Serum IgG, IgM and IgA levels were measured by the single radial diffusion method in 107 South African Negro patients with primary hepatocellular cancer (PHC) and 112 healthy Negro blood donors. The mean serum IgG ANd IgM concentrations were significantly higher (P less than 0-001) in the PHC patien...
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| Veröffentlicht in: | British journal of cancer 1975-10, Vol.32 (4), p.509-511 |
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| creator | Ipp, T Macnab, G M Geddes, E W Kew, M C |
| description | Serum IgG, IgM and IgA levels were measured by the single radial diffusion method in 107 South African Negro patients with primary hepatocellular cancer (PHC) and 112 healthy Negro blood donors. The mean serum IgG ANd IgM concentrations were significantly higher (P less than 0-001) in the PHC patients. In those patients in whom PHC was associated with cirrhosis, the serum IgG level was greater (P less than 0-02) than in those without cirrhosis. However, the mean serum IgG concentration in the non-cirrhotic cancer patients was still significantly higher than the control value (P less than 0-001). Thus, while cirrhosis may contribute to the raised IgG levels in PHC, other factors must also be involved. There was no difference in the serum immunoglobulin concentrations in PHC patients with and without hepatitis-B antigenaemia. |
| doi_str_mv | 10.1038/bjc.1975.253 |
| format | Article |
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The mean serum IgG ANd IgM concentrations were significantly higher (P less than 0-001) in the PHC patients. In those patients in whom PHC was associated with cirrhosis, the serum IgG level was greater (P less than 0-02) than in those without cirrhosis. However, the mean serum IgG concentration in the non-cirrhotic cancer patients was still significantly higher than the control value (P less than 0-001). Thus, while cirrhosis may contribute to the raised IgG levels in PHC, other factors must also be involved. There was no difference in the serum immunoglobulin concentrations in PHC patients with and without hepatitis-B antigenaemia.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1975.253</identifier><identifier>PMID: 174706</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; African Americans ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Hepatocellular - immunology ; Drug Resistance ; Epidemiology ; Hepatitis B - complications ; Hepatitis B Antigens - analysis ; Humans ; Immunoglobulin A - analysis ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis ; Immunoglobulins - analysis ; Liver Cirrhosis - complications ; Liver Cirrhosis - immunology ; Liver Neoplasms - complications ; Liver Neoplasms - immunology ; Male ; Middle Aged ; Molecular Medicine ; Oncology ; original-article</subject><ispartof>British journal of cancer, 1975-10, Vol.32 (4), p.509-511</ispartof><rights>Cancer Research Campaign 1975</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-1b22f99bcd8340e35e3c007e4941d8ee878c266f31c40fe9a745c472400326f43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024768/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024768/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/174706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ipp, T</creatorcontrib><creatorcontrib>Macnab, G M</creatorcontrib><creatorcontrib>Geddes, E W</creatorcontrib><creatorcontrib>Kew, M C</creatorcontrib><title>Serum immunoglobulin levels in primary liver cancer: relationship to underlying cirrhosis and hepatitis-B (surface) antigenaemia</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Serum IgG, IgM and IgA levels were measured by the single radial diffusion method in 107 South African Negro patients with primary hepatocellular cancer (PHC) and 112 healthy Negro blood donors. The mean serum IgG ANd IgM concentrations were significantly higher (P less than 0-001) in the PHC patients. In those patients in whom PHC was associated with cirrhosis, the serum IgG level was greater (P less than 0-02) than in those without cirrhosis. However, the mean serum IgG concentration in the non-cirrhotic cancer patients was still significantly higher than the control value (P less than 0-001). Thus, while cirrhosis may contribute to the raised IgG levels in PHC, other factors must also be involved. There was no difference in the serum immunoglobulin concentrations in PHC patients with and without hepatitis-B antigenaemia.</description><subject>Adult</subject><subject>African Americans</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Hepatocellular - immunology</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B Antigens - analysis</subject><subject>Humans</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Immunoglobulins - analysis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - immunology</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>original-article</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-P1CAYholx1dnVm0cPnIwm25FfLa0HE924arKJB_VMKP3aYUJhFsoke_NPl3Emqx48AXmfvPDxIPSckjUlvH3Tb82adrJes5o_QCtac1bRlsmHaEUIkRXpGHmCzlPalmNHWvkYPaJSSNKs0M9vEPOM7TxnHyYX-uysxw724BIuu120s4532Nk9RGy0NxDf4ghOLzb4tLE7vASc_QDR3Vk_YWNj3IRkE9Z-wBvYFXCxqfqAX6UcR23gdUkWO4HXMFv9FJ2N2iV4dlov0I_rj9-vPlc3Xz99uXp_Uxkh6FLRnrGx63oztFwQ4DVwU2YD0Qk6tACtbA1rmpFTI8gInZaiNkIyQQhnzSj4BXp37N3lfobBgF-iduo0nwraqn8TbzdqCnvFCBOyaUvBy1NBDLcZ0qJmmww4pz2EnFTLqWS8awp4eQRNDClFGO8voUQdhKkiTB2EqSKs4C_-ftgf-LehElfHOJXATxDVNuToy1f9rw4fea-XHOG-rkAH5oD8Aqf7row</recordid><startdate>19751001</startdate><enddate>19751001</enddate><creator>Ipp, T</creator><creator>Macnab, G M</creator><creator>Geddes, E W</creator><creator>Kew, M C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19751001</creationdate><title>Serum immunoglobulin levels in primary liver cancer: relationship to underlying cirrhosis and hepatitis-B (surface) antigenaemia</title><author>Ipp, T ; Macnab, G M ; Geddes, E W ; Kew, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-1b22f99bcd8340e35e3c007e4941d8ee878c266f31c40fe9a745c472400326f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Hepatocellular - immunology</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B Antigens - analysis</topic><topic>Humans</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Immunoglobulins - analysis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - immunology</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>original-article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ipp, T</creatorcontrib><creatorcontrib>Macnab, G M</creatorcontrib><creatorcontrib>Geddes, E W</creatorcontrib><creatorcontrib>Kew, M C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ipp, T</au><au>Macnab, G M</au><au>Geddes, E W</au><au>Kew, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum immunoglobulin levels in primary liver cancer: relationship to underlying cirrhosis and hepatitis-B (surface) antigenaemia</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1975-10-01</date><risdate>1975</risdate><volume>32</volume><issue>4</issue><spage>509</spage><epage>511</epage><pages>509-511</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Serum IgG, IgM and IgA levels were measured by the single radial diffusion method in 107 South African Negro patients with primary hepatocellular cancer (PHC) and 112 healthy Negro blood donors. The mean serum IgG ANd IgM concentrations were significantly higher (P less than 0-001) in the PHC patients. In those patients in whom PHC was associated with cirrhosis, the serum IgG level was greater (P less than 0-02) than in those without cirrhosis. However, the mean serum IgG concentration in the non-cirrhotic cancer patients was still significantly higher than the control value (P less than 0-001). Thus, while cirrhosis may contribute to the raised IgG levels in PHC, other factors must also be involved. There was no difference in the serum immunoglobulin concentrations in PHC patients with and without hepatitis-B antigenaemia.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>174706</pmid><doi>10.1038/bjc.1975.253</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult African Americans Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Hepatocellular - immunology Drug Resistance Epidemiology Hepatitis B - complications Hepatitis B Antigens - analysis Humans Immunoglobulin A - analysis Immunoglobulin G - analysis Immunoglobulin M - analysis Immunoglobulins - analysis Liver Cirrhosis - complications Liver Cirrhosis - immunology Liver Neoplasms - complications Liver Neoplasms - immunology Male Middle Aged Molecular Medicine Oncology original-article |
| title | Serum immunoglobulin levels in primary liver cancer: relationship to underlying cirrhosis and hepatitis-B (surface) antigenaemia |
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