Cathepsin S Deficiency Confers Protection from Neonatal Hyperoxia-induced Lung Injury

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elas...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2007-10, Vol.176 (8), p.778-785
Hauptverfasser:	Hirakawa, Hiroshi, Pierce, Richard A, Bingol-Karakoc, Gulbin, Karaaslan, Cagatay, Weng, MeiQian, Shi, Guo-Ping, Saad, Ali, Weber, Ekkehard, Mariani, Thomas J, Starcher, Barry, Shapiro, Steve D, Cataltepe, Sule
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antibodies Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchopulmonary Dysplasia - metabolism C. Critical Care Cathepsins - deficiency Cathepsins - metabolism Collagen - metabolism Desmosine - metabolism Disease Models, Animal Elastin - metabolism Humans Hydroxyproline - metabolism Hyperoxia Hyperoxia - complications Hyperoxia - metabolism Infant, Newborn Lavage Lung - metabolism Lung - pathology Lung diseases Lung Injury Lungs Macrophages, Alveolar - metabolism Mice Newborn babies Premature babies Proteins Proteins - metabolism Pulmonary Alveoli - growth & development RNA, Messenger - metabolism Smooth muscle Surfactants Ventilators
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