Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85
Cultures and culture filtrates of Bacillus cereus UW85 suppress damping-off of alfalfa caused by Phytophthora medicaginis. We studied the role in disease suppression of two antibiotics from culture filtrates of UW85 that reversibly inhibited growth of P. medicaginis. We purified the two antibiotics...
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| Veröffentlicht in: | Applied and Environmental Microbiology 1994-06, Vol.60 (6), p.2023-2030 |
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| creator | Silo-Suh, L.A Lethbridge, B.J Raffel, S.J He, H Clardy, J Handelsman, J |
| description | Cultures and culture filtrates of Bacillus cereus UW85 suppress damping-off of alfalfa caused by Phytophthora medicaginis. We studied the role in disease suppression of two antibiotics from culture filtrates of UW85 that reversibly inhibited growth of P. medicaginis. We purified the two antibiotics by cation-exchange chromatography and high-voltage paper electrophoresis and showed that one of them, designated zwittermicin A, was an aminopolyol of 396 Da that was cationic at pH 7.0; the second, designated antibiotic B, appeared to be an aminoglycoside containing a disaccharide. Both antibiotics prevented disease of alfalfa seedlings caused by P. medicaginis. Purified zwittermicin A reversibly reduced elongation of germ tubes derived from cysts of P. medicaginis, and antibiotic B caused swelling of the germ tubes. Mutants generated with Tn917 or mitomycin C treatment were screened either for antibiotic accumulation in an agar plate diffusion assay or for the ability to suppress damping-off disease of alfalfa. Of 2,682 mutants screened for antibiotic accumulation, 5 mutants were substantially reduced in antibiotic accumulation and disease-suppressive activity. Of the 1,700 mutants screened for disease-suppressive activity, 3 mutants had reduced activity and they accumulated less of both antibiotics than did the parent strain. The amount of antibiotic accumulated by the mutants was significantly correlated with the level of disease suppression. Addition of either zwittermicin A or antibiotic B to alfalfa plants inoculated with a culture of a nonsuppressive mutant resulted in disease suppression. These results demonstrate that B. cereus UW85 produces two fungistatic antibiotics that contribute to suppression of damping-off disease of alfalfa |
| doi_str_mv | 10.1128/aem.60.6.2023-2030.1994 |
| format | Article |
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We studied the role in disease suppression of two antibiotics from culture filtrates of UW85 that reversibly inhibited growth of P. medicaginis. We purified the two antibiotics by cation-exchange chromatography and high-voltage paper electrophoresis and showed that one of them, designated zwittermicin A, was an aminopolyol of 396 Da that was cationic at pH 7.0; the second, designated antibiotic B, appeared to be an aminoglycoside containing a disaccharide. Both antibiotics prevented disease of alfalfa seedlings caused by P. medicaginis. Purified zwittermicin A reversibly reduced elongation of germ tubes derived from cysts of P. medicaginis, and antibiotic B caused swelling of the germ tubes. Mutants generated with Tn917 or mitomycin C treatment were screened either for antibiotic accumulation in an agar plate diffusion assay or for the ability to suppress damping-off disease of alfalfa. Of 2,682 mutants screened for antibiotic accumulation, 5 mutants were substantially reduced in antibiotic accumulation and disease-suppressive activity. Of the 1,700 mutants screened for disease-suppressive activity, 3 mutants had reduced activity and they accumulated less of both antibiotics than did the parent strain. The amount of antibiotic accumulated by the mutants was significantly correlated with the level of disease suppression. Addition of either zwittermicin A or antibiotic B to alfalfa plants inoculated with a culture of a nonsuppressive mutant resulted in disease suppression. These results demonstrate that B. cereus UW85 produces two fungistatic antibiotics that contribute to suppression of damping-off disease of alfalfa</description><identifier>ISSN: 0099-2240</identifier><identifier>EISSN: 1098-5336</identifier><identifier>DOI: 10.1128/aem.60.6.2023-2030.1994</identifier><identifier>PMID: 8031096</identifier><identifier>CODEN: AEMIDF</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Agronomy. Soil science and plant productions ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiosis ; ANTIBIOTICOS ; Antibiotics ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; ANTIBIOTIQUE ; Applied microbiology ; BACILLUS CEREUS ; Bacillus cereus - chemistry ; Bacteria ; Biological and medical sciences ; Biological control ; Biology of microorganisms of confirmed or potential industrial interest ; Biotechnology ; Control ; CONTROL DE ENFERMEDADES ; CONTROLE DE MALADIES ; Disease ; Erwinia - drug effects ; Flowers & plants ; FONGICIDE ; Fundamental and applied biological sciences. Psychology ; Fungal plant pathogens ; Fungi ; FUNGICIDAS ; MEDICAGO SATIVA ; Microbiology ; Miscellaneous ; Mission oriented research ; Mutation ; Mycoses - prevention & control ; Pathology ; Peptides ; PESTICIDE MICROBIEN ; PHOMA MEDICAGINIS ; Phytopathology. Animal pests. Plant and forest protection ; Phytophthora - drug effects ; Phytophthora - growth & development ; Phytophthora medicaginis ; PLAGUICIDAS MICROBIANOS ; Plant Diseases - microbiology ; PROPIEDADES ANTIMICOSICAS ; PROPRIETE ANTIFONGIQUE</subject><ispartof>Applied and Environmental Microbiology, 1994-06, Vol.60 (6), p.2023-2030</ispartof><rights>1994 INIST-CNRS</rights><rights>Copyright American Society for Microbiology Jun 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5784-230e9d98f8eac675d770870fbb2eb07c4d8c4c160d6f039be7a9974c5183cb343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC201597/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC201597/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,3176,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4151679$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8031096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silo-Suh, L.A</creatorcontrib><creatorcontrib>Lethbridge, B.J</creatorcontrib><creatorcontrib>Raffel, S.J</creatorcontrib><creatorcontrib>He, H</creatorcontrib><creatorcontrib>Clardy, J</creatorcontrib><creatorcontrib>Handelsman, J</creatorcontrib><title>Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85</title><title>Applied and Environmental Microbiology</title><addtitle>Appl Environ Microbiol</addtitle><description>Cultures and culture filtrates of Bacillus cereus UW85 suppress damping-off of alfalfa caused by Phytophthora medicaginis. We studied the role in disease suppression of two antibiotics from culture filtrates of UW85 that reversibly inhibited growth of P. medicaginis. We purified the two antibiotics by cation-exchange chromatography and high-voltage paper electrophoresis and showed that one of them, designated zwittermicin A, was an aminopolyol of 396 Da that was cationic at pH 7.0; the second, designated antibiotic B, appeared to be an aminoglycoside containing a disaccharide. Both antibiotics prevented disease of alfalfa seedlings caused by P. medicaginis. Purified zwittermicin A reversibly reduced elongation of germ tubes derived from cysts of P. medicaginis, and antibiotic B caused swelling of the germ tubes. Mutants generated with Tn917 or mitomycin C treatment were screened either for antibiotic accumulation in an agar plate diffusion assay or for the ability to suppress damping-off disease of alfalfa. Of 2,682 mutants screened for antibiotic accumulation, 5 mutants were substantially reduced in antibiotic accumulation and disease-suppressive activity. Of the 1,700 mutants screened for disease-suppressive activity, 3 mutants had reduced activity and they accumulated less of both antibiotics than did the parent strain. The amount of antibiotic accumulated by the mutants was significantly correlated with the level of disease suppression. Addition of either zwittermicin A or antibiotic B to alfalfa plants inoculated with a culture of a nonsuppressive mutant resulted in disease suppression. These results demonstrate that B. cereus UW85 produces two fungistatic antibiotics that contribute to suppression of damping-off disease of alfalfa</description><subject>Agronomy. Soil science and plant productions</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiosis</subject><subject>ANTIBIOTICOS</subject><subject>Antibiotics</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>ANTIBIOTIQUE</subject><subject>Applied microbiology</subject><subject>BACILLUS CEREUS</subject><subject>Bacillus cereus - chemistry</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Biological control</subject><subject>Biology of microorganisms of confirmed or potential industrial interest</subject><subject>Biotechnology</subject><subject>Control</subject><subject>CONTROL DE ENFERMEDADES</subject><subject>CONTROLE DE MALADIES</subject><subject>Disease</subject><subject>Erwinia - drug effects</subject><subject>Flowers & plants</subject><subject>FONGICIDE</subject><subject>Fundamental and applied biological sciences. 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Plant and forest protection</subject><subject>Phytophthora - drug effects</subject><subject>Phytophthora - growth & development</subject><subject>Phytophthora medicaginis</subject><subject>PLAGUICIDAS MICROBIANOS</subject><subject>Plant Diseases - microbiology</subject><subject>PROPIEDADES ANTIMICOSICAS</subject><subject>PROPRIETE ANTIFONGIQUE</subject><issn>0099-2240</issn><issn>1098-5336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EKkPhDyAhAkLsMly_7QULWvGSKrGAEUvLcZyMq0w8tZNW_fc4mtGIsmF1Ld_v3HPtg9BrDGuMifpg_W4tYC3WBAitCdByrzV7hFYYtKo5peIxWgFoXRPC4Cl6lvM1ADAQ6gydKaCFEyu0uQhxiH1wdqism8JtmILPVeyq6S5W3Tz2IU92Cq6y4xSaEMsxV_sU29n5tmruqwvrwjDMuXI--VI2vxV_jp50dsj-xbGeo82Xz78uv9VXP75-v_x0VTsuFasJBa9brTrlrROSt1KCktA1DfENSMda5ZjDAlrRAdWNl1ZryRzHirqGMnqOPh7m7udm51vnxynZwexT2Nl0b6IN5mFnDFvTx1tDAHMti_79UZ_izezzZHYhOz8MdvRxzkYKXgwl_S-IhaYM2LLR23_A6zinsXxC8eSaKArLNHmAXIo5J9-dNsZglnhNidcIMMIs8ZolXrPEW5Sv_n7wSXfMs_TfHfs2l0i7ZEcX8gljmGMhdcHeHLBt6Ld3IXlj8-6haWFeHpjORmP7VMZsfmoOWAGjfwCl58IF</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Silo-Suh, L.A</creator><creator>Lethbridge, B.J</creator><creator>Raffel, S.J</creator><creator>He, H</creator><creator>Clardy, J</creator><creator>Handelsman, J</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940601</creationdate><title>Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85</title><author>Silo-Suh, L.A ; Lethbridge, B.J ; Raffel, S.J ; He, H ; Clardy, J ; Handelsman, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5784-230e9d98f8eac675d770870fbb2eb07c4d8c4c160d6f039be7a9974c5183cb343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Agronomy. Soil science and plant productions</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiosis</topic><topic>ANTIBIOTICOS</topic><topic>Antibiotics</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>ANTIBIOTIQUE</topic><topic>Applied microbiology</topic><topic>BACILLUS CEREUS</topic><topic>Bacillus cereus - chemistry</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Biological control</topic><topic>Biology of microorganisms of confirmed or potential industrial interest</topic><topic>Biotechnology</topic><topic>Control</topic><topic>CONTROL DE ENFERMEDADES</topic><topic>CONTROLE DE MALADIES</topic><topic>Disease</topic><topic>Erwinia - drug effects</topic><topic>Flowers & plants</topic><topic>FONGICIDE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal plant pathogens</topic><topic>Fungi</topic><topic>FUNGICIDAS</topic><topic>MEDICAGO SATIVA</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mission oriented research</topic><topic>Mutation</topic><topic>Mycoses - prevention & control</topic><topic>Pathology</topic><topic>Peptides</topic><topic>PESTICIDE MICROBIEN</topic><topic>PHOMA MEDICAGINIS</topic><topic>Phytopathology. Animal pests. 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We studied the role in disease suppression of two antibiotics from culture filtrates of UW85 that reversibly inhibited growth of P. medicaginis. We purified the two antibiotics by cation-exchange chromatography and high-voltage paper electrophoresis and showed that one of them, designated zwittermicin A, was an aminopolyol of 396 Da that was cationic at pH 7.0; the second, designated antibiotic B, appeared to be an aminoglycoside containing a disaccharide. Both antibiotics prevented disease of alfalfa seedlings caused by P. medicaginis. Purified zwittermicin A reversibly reduced elongation of germ tubes derived from cysts of P. medicaginis, and antibiotic B caused swelling of the germ tubes. Mutants generated with Tn917 or mitomycin C treatment were screened either for antibiotic accumulation in an agar plate diffusion assay or for the ability to suppress damping-off disease of alfalfa. Of 2,682 mutants screened for antibiotic accumulation, 5 mutants were substantially reduced in antibiotic accumulation and disease-suppressive activity. Of the 1,700 mutants screened for disease-suppressive activity, 3 mutants had reduced activity and they accumulated less of both antibiotics than did the parent strain. The amount of antibiotic accumulated by the mutants was significantly correlated with the level of disease suppression. Addition of either zwittermicin A or antibiotic B to alfalfa plants inoculated with a culture of a nonsuppressive mutant resulted in disease suppression. These results demonstrate that B. cereus UW85 produces two fungistatic antibiotics that contribute to suppression of damping-off disease of alfalfa</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>8031096</pmid><doi>10.1128/aem.60.6.2023-2030.1994</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Agronomy. Soil science and plant productions Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiosis ANTIBIOTICOS Antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ANTIBIOTIQUE Applied microbiology BACILLUS CEREUS Bacillus cereus - chemistry Bacteria Biological and medical sciences Biological control Biology of microorganisms of confirmed or potential industrial interest Biotechnology Control CONTROL DE ENFERMEDADES CONTROLE DE MALADIES Disease Erwinia - drug effects Flowers & plants FONGICIDE Fundamental and applied biological sciences. Psychology Fungal plant pathogens Fungi FUNGICIDAS MEDICAGO SATIVA Microbiology Miscellaneous Mission oriented research Mutation Mycoses - prevention & control Pathology Peptides PESTICIDE MICROBIEN PHOMA MEDICAGINIS Phytopathology. Animal pests. Plant and forest protection Phytophthora - drug effects Phytophthora - growth & development Phytophthora medicaginis PLAGUICIDAS MICROBIANOS Plant Diseases - microbiology PROPIEDADES ANTIMICOSICAS PROPRIETE ANTIFONGIQUE |
| title | Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85 |
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