Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

Aims To determine the human cytochromes mediating biotransformation of the imidazopyridine hypnotic, zolpidem, and the clinical correlates of the findings. Methods Kinetic properties of zolpidem biotransformation to its three hydroxylated metabolites were studied in vitro using human liver microsome...

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Veröffentlicht in:	British journal of clinical pharmacology 1999-07, Vol.48 (1), p.89-97
Hauptverfasser:	Von Moltke, Lisa L., Greenblatt, David J., Granda, Brian W., Duan, Su Xiang, Grassi, Jeffrey M., Venkatakrishnan, Karthik, Harmatz, Jerold S., Shader, Richard I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotransformation Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochromes P450 drug interactions Enzyme Inhibitors - pharmacology Humans Hypnotics and Sedatives - metabolism Hypnotics. Sedatives in vitro metabolism In Vitro Techniques ketoconazole Ketoconazole - pharmacology Medical sciences Metabolic Clearance Rate Microsomes, Liver - metabolism Neuropharmacology Original Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyridines - metabolism Transfection Tumor Cells, Cultured Zolpidem
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