Genetic pleiotropy between asthma and obesity in a community-based sample of twins
Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes. We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2005-12, Vol.116 (6), p.1235-1241 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Hallstrand, Teal S. Fischer, Mary E. Wurfel, Mark M. Afari, Niloofar Buchwald, Dedra Goldberg, Jack |
| description | Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes.
We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause.
The analyses were performed with 1001 monozygotic and 383 dizygotic same-sex twin pairs within the University of Washington Twin Registry. The presence of asthma was determined by self-report of a physician diagnosis of asthma, and body mass index (BMI) was calculated by using self-reported height and weight. Obesity was defined as a BMI of 30 or greater. The association between asthma and BMI was assessed by means of mixed-effects ordinal regression. Twin correlations examined the association of asthma and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental effects.
A strong association between asthma and BMI was identified in the sample population (
P < .001). Substantial heritability was detected for asthma (53%) and obesity (77%), which is indicative of additive genetic influences on each disorder. The best-fitting model of shared components of variance indicated that 8% of the genetic component of obesity is shared with asthma.
The covariation between obesity and asthma is predominantly caused by shared genetic risk factors for both conditions. |
| doi_str_mv | 10.1016/j.jaci.2005.09.016 |
| format | Article |
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We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause.
The analyses were performed with 1001 monozygotic and 383 dizygotic same-sex twin pairs within the University of Washington Twin Registry. The presence of asthma was determined by self-report of a physician diagnosis of asthma, and body mass index (BMI) was calculated by using self-reported height and weight. Obesity was defined as a BMI of 30 or greater. The association between asthma and BMI was assessed by means of mixed-effects ordinal regression. Twin correlations examined the association of asthma and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental effects.
A strong association between asthma and BMI was identified in the sample population (
P < .001). Substantial heritability was detected for asthma (53%) and obesity (77%), which is indicative of additive genetic influences on each disorder. The best-fitting model of shared components of variance indicated that 8% of the genetic component of obesity is shared with asthma.
The covariation between obesity and asthma is predominantly caused by shared genetic risk factors for both conditions.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2005.09.016</identifier><identifier>PMID: 16337451</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Age ; Aged ; Asthma ; Asthma - etiology ; Asthma - genetics ; Biological and medical sciences ; Body Mass Index ; Diseases in Twins - genetics ; Ethnicity ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; genetic ; Humans ; Immunopathology ; Medical sciences ; Middle Aged ; Models, Genetic ; Obesity ; Obesity - etiology ; Obesity - genetics ; Quantitative genetics ; Risk Factors ; Studies ; twin ; Twins ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Journal of allergy and clinical immunology, 2005-12, Vol.116 (6), p.1235-1241</ispartof><rights>2005 American Academy of Allergy, Asthma and Immunology</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Dec 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-c414ef58a2cf47cf1e09716636214de60d5ff11a04d0e69a8ae7c51d6660151e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674905020646$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17358511$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16337451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hallstrand, Teal S.</creatorcontrib><creatorcontrib>Fischer, Mary E.</creatorcontrib><creatorcontrib>Wurfel, Mark M.</creatorcontrib><creatorcontrib>Afari, Niloofar</creatorcontrib><creatorcontrib>Buchwald, Dedra</creatorcontrib><creatorcontrib>Goldberg, Jack</creatorcontrib><title>Genetic pleiotropy between asthma and obesity in a community-based sample of twins</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes.
We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause.
The analyses were performed with 1001 monozygotic and 383 dizygotic same-sex twin pairs within the University of Washington Twin Registry. The presence of asthma was determined by self-report of a physician diagnosis of asthma, and body mass index (BMI) was calculated by using self-reported height and weight. Obesity was defined as a BMI of 30 or greater. The association between asthma and BMI was assessed by means of mixed-effects ordinal regression. Twin correlations examined the association of asthma and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental effects.
A strong association between asthma and BMI was identified in the sample population (
P < .001). Substantial heritability was detected for asthma (53%) and obesity (77%), which is indicative of additive genetic influences on each disorder. The best-fitting model of shared components of variance indicated that 8% of the genetic component of obesity is shared with asthma.
The covariation between obesity and asthma is predominantly caused by shared genetic risk factors for both conditions.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Asthma</subject><subject>Asthma - etiology</subject><subject>Asthma - genetics</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Diseases in Twins - genetics</subject><subject>Ethnicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>genetic</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Genetic</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - genetics</subject><subject>Quantitative genetics</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>twin</subject><subject>Twins</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-LFDEQxYMo7uzqF_AgDaK3blPd-dcggizuKiwIoueQSVe7abqTMUnvMt_eDDO46sFTqKrfK17lEfICaAMUxNupmYx1TUspb2jflNYjsgHay1qolj8mG0p7qIVk_Rk5T2mipe5U_5Scgeg6yThsyNdr9JidrXYzupBj2O2rLeZ7RF-ZlG8XUxk_VGGLyeV95Uq3smFZVl_KemsSDlUyS1FXYazyvfPpGXkymjnh89N7Qb5fffx2-am--XL9-fLDTW25lLm2DBiOXJnWjkzaEbA4ByE60QIbUNCBjyOAoWygKHqjDErLYRBCUOCA3QV5f9y7W7cLDhZ9jmbWu-gWE_c6GKf_nnh3q3-EO91SYFJ1ZcGb04IYfq6Ysl5csjjPxmNYkxZKKaYULeCrf8AprNGX4zRwyiRrW9YWqj1SNoaUIo6_rQDVh8D0pA-B6UNgmva6tIro5Z9HPEhOCRXg9QkwyZp5jMZblx442XHF4cC9O3JYvvzOYdTJOvQWBxfRZj0E9z8fvwD3lLSR</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Hallstrand, Teal S.</creator><creator>Fischer, Mary E.</creator><creator>Wurfel, Mark M.</creator><creator>Afari, Niloofar</creator><creator>Buchwald, Dedra</creator><creator>Goldberg, Jack</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20051201</creationdate><title>Genetic pleiotropy between asthma and obesity in a community-based sample of twins</title><author>Hallstrand, Teal S. ; Fischer, Mary E. ; Wurfel, Mark M. ; Afari, Niloofar ; Buchwald, Dedra ; Goldberg, Jack</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-c414ef58a2cf47cf1e09716636214de60d5ff11a04d0e69a8ae7c51d6660151e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Asthma</topic><topic>Asthma - etiology</topic><topic>Asthma - genetics</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Diseases in Twins - genetics</topic><topic>Ethnicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>genetic</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Genetic</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - genetics</topic><topic>Quantitative genetics</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>twin</topic><topic>Twins</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hallstrand, Teal S.</creatorcontrib><creatorcontrib>Fischer, Mary E.</creatorcontrib><creatorcontrib>Wurfel, Mark M.</creatorcontrib><creatorcontrib>Afari, Niloofar</creatorcontrib><creatorcontrib>Buchwald, Dedra</creatorcontrib><creatorcontrib>Goldberg, Jack</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hallstrand, Teal S.</au><au>Fischer, Mary E.</au><au>Wurfel, Mark M.</au><au>Afari, Niloofar</au><au>Buchwald, Dedra</au><au>Goldberg, Jack</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic pleiotropy between asthma and obesity in a community-based sample of twins</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>116</volume><issue>6</issue><spage>1235</spage><epage>1241</epage><pages>1235-1241</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes.
We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause.
The analyses were performed with 1001 monozygotic and 383 dizygotic same-sex twin pairs within the University of Washington Twin Registry. The presence of asthma was determined by self-report of a physician diagnosis of asthma, and body mass index (BMI) was calculated by using self-reported height and weight. Obesity was defined as a BMI of 30 or greater. The association between asthma and BMI was assessed by means of mixed-effects ordinal regression. Twin correlations examined the association of asthma and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental effects.
A strong association between asthma and BMI was identified in the sample population (
P < .001). Substantial heritability was detected for asthma (53%) and obesity (77%), which is indicative of additive genetic influences on each disorder. The best-fitting model of shared components of variance indicated that 8% of the genetic component of obesity is shared with asthma.
The covariation between obesity and asthma is predominantly caused by shared genetic risk factors for both conditions.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16337451</pmid><doi>10.1016/j.jaci.2005.09.016</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Age Aged Asthma Asthma - etiology Asthma - genetics Biological and medical sciences Body Mass Index Diseases in Twins - genetics Ethnicity Fundamental and applied biological sciences. Psychology Fundamental immunology genetic Humans Immunopathology Medical sciences Middle Aged Models, Genetic Obesity Obesity - etiology Obesity - genetics Quantitative genetics Risk Factors Studies twin Twins Twins, Dizygotic Twins, Monozygotic |
| title | Genetic pleiotropy between asthma and obesity in a community-based sample of twins |
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