The antiepileptic and anticancer agent, valproic acid, induces P‐glycoprotein in human tumour cell lines and in rat liver

Background and purpose: The antiepileptic drug valproic acid, a histone deacetylase (HDAC) inhibitor, is currently being tested as an anticancer agent. However, HDAC inhibitors may interact with anticancer drugs through induction of P‐glycoprotein (P‐gp, MDR1) expression. In this study we assessed w...

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Veröffentlicht in:	British journal of pharmacology 2006-10, Vol.149 (3), p.250-260
Hauptverfasser:	Eyal, S, Lamb, J G, Smith‐Yockman, M, Yagen, B, Fibach, E, Altschuler, Y, White, H S, Bialer, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Anticonvulsants - pharmacology Antineoplastic Agents - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis Biological and medical sciences CYP3A4 Cytochrome P-450 CYP3A - biosynthesis histone deacetylase Histone Deacetylase Inhibitors Histones - metabolism Humans Liver - drug effects Liver - metabolism Male Medical sciences multidrug resistance protein 1 Pharmacology. Drug treatments P‐glycoprotein Rats Rats, Sprague-Dawley Research Papers Tumor Cells, Cultured valproic acid Valproic Acid - pharmacology
Online-Zugang:	Volltext
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