Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats

Background and purpose: Glucokinase (GK) is the rate‐limiting enzyme of hepatic glucose metabolism and acts as a sensor for glucose‐stimulated insulin release in β‐cells. Here we examine whether the lowering of blood glucose levels in the rat by small molecule glucokinase activators (GKAs) can be pr...

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