The influence of CYP2D6 activity on the kinetics of propafenone enantiomers in Chinese subjects

Aims To determine role of CYP2D6 activity in the pharmacokinetics of propafenone (PPF) enantiomers in native Chinese subjects. Methods Sixteen extensive metabolizers (EMs) and one poor metabolizer (PM), whose phenotype had been previously assessed with dextromethorphan metabolic phenotyping, were en...

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Veröffentlicht in:	British journal of clinical pharmacology 1999-05, Vol.47 (5), p.553-556
Hauptverfasser:	CAI, W. M, CHEN, B, CAI, M. H, CHEN, Y, ZHANG, Y. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Anti-Arrhythmia Agents - adverse effects Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - pharmacokinetics Antiarythmic agents Area Under Curve Biological and medical sciences Cardiovascular system China Chinese CYP2D6 Cytochrome P-450 CYP2D6 - metabolism Dizziness - chemically induced enantiomer Female Humans Male Medical sciences Middle Aged Nausea - chemically induced Original pharmacokinetics Pharmacology. Drug treatments phenotype propafenone Propafenone - adverse effects Propafenone - chemistry Propafenone - pharmacokinetics Stereoisomerism Stomach Diseases - chemically induced
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