Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw
Background and purpose: α‐Humulene and trans‐caryophyllene are sesquiterpene compounds identified in the essential oil of Cordia verbenacea which display topical and systemic anti‐inflammatory effects in different experimental models. However, the molecular mechanisms through which they exert their...
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| Veröffentlicht in: | British journal of pharmacology 2007-07, Vol.151 (5), p.618-627 |
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| creator | Medeiros, R Passos, G F Vitor, C E Koepp, J Mazzuco, T L Pianowski, L F Campos, M M Calixto, J B |
| description | Background and purpose:
α‐Humulene and trans‐caryophyllene are sesquiterpene compounds identified in the essential oil of Cordia verbenacea which display topical and systemic anti‐inflammatory effects in different experimental models. However, the molecular mechanisms through which they exert their anti‐inflammatory activity still remain unclear. Here, we evaluate the effects of α‐humulene and trans‐caryophyllene on the acute inflammatory responses elicited by LPS.
Experimental approach:
The biological activities of α‐humulene and trans‐caryophyllene were investigated in a model of acute inflammation in rat paw, induced by LPS and characterized by paw oedema, neutrophil recruitment, cytokine production, activation of MAP kinases and NF‐κB and up‐regulated expression of kinin B1 receptors.
Key results:
Treatment with either α‐humulene or trans‐caryophyllene effectively reduced neutrophil migration and activation of NF‐κB induced by LPS in the rat paw. However, only α‐humulene significantly reduced the increase in TNF‐α and IL‐1β levels, paw oedema and the up‐regulation of B1 receptors following treatment with LPS. Both compounds failed to interfere with the activation of the MAP kinases, ERK, p38 and JNK.
Conclusions and Implications:
Both α‐humulene and trans‐caryophyllene inhibit the LPS‐induced NF‐κB activation and neutrophil migration, although only α‐humulene had the ability to prevent the production of pro‐inflammatory cytokines TNF‐α and IL‐1β and the in vivo up‐regulation of kinin B1 receptors. These data provide additional molecular and functional insights into the beneficial effects of the sesquiterpenes α‐humulene and trans‐caryophyllene isolated from the essential oil of Cordia verbenacea as agents for the management of inflammatory diseases.
British Journal of Pharmacology (2007) 151, 618–627; doi:10.1038/sj.bjp.0707270 |
| doi_str_mv | 10.1038/sj.bjp.0707270 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2013990</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1298100661</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5195-4d1b0b0e4f4aa8c526a92480e714cc2dc6171d4a9df9e2b5d63910063d2e49f63</originalsourceid><addsrcrecordid>eNqFks2O0zAUhS0EYkphyxJZSLBLsR0nTjZIQzUwSJUYCVhbN8414yqJg5206ovwvLjTigE2s7EX9zvn_ugQ8pKzFWd59S5uV812XDHFlFDsEVlwqcqsyCv-mCwYYyrjvKouyLMYt4yloiqekguupOLpWZBfV9aimai3dNp7CmZyO6TG96OfhzZS30zgBmypDb6n0y1SjBGHyUFHveuOurUPrQO6w9DgAAaB-uGOBDNPSN1gO-h7mHw40IBx9EPESLFzxk3JuDnQzc3XhN1pAkx0hP1z8sRCF_HF-V-S7x-vvq2vs82XT5_Xl5vMFLwuMtnyhjUMpZUAlSlECbWQFUPFpTGiNSVXvJVQt7ZG0RRtmdecsTJvBcralvmSvD_5jnPTY2vSZgE6PQbXQzhoD07_Wxncrf7hd1owntc1SwZvzwbB_5wxTrp30WDXwYB-jlqxskijlg-CgolS1ezo-Po_cOvnMKQraMGV4Fym1kuyOkEm-BgD2j8jc6aPwdBxq1Mw9DkYSfDq70Xv8XMSEvDmDEA00NkAg3Hxnququko-iRMnbu86PDzQVn-4uZayyH8D0sfT-w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217211401</pqid></control><display><type>article</type><title>Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw</title><source>PubMed Central Free</source><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Medeiros, R ; Passos, G F ; Vitor, C E ; Koepp, J ; Mazzuco, T L ; Pianowski, L F ; Campos, M M ; Calixto, J B</creator><creatorcontrib>Medeiros, R ; Passos, G F ; Vitor, C E ; Koepp, J ; Mazzuco, T L ; Pianowski, L F ; Campos, M M ; Calixto, J B</creatorcontrib><description>Background and purpose:
α‐Humulene and trans‐caryophyllene are sesquiterpene compounds identified in the essential oil of Cordia verbenacea which display topical and systemic anti‐inflammatory effects in different experimental models. However, the molecular mechanisms through which they exert their anti‐inflammatory activity still remain unclear. Here, we evaluate the effects of α‐humulene and trans‐caryophyllene on the acute inflammatory responses elicited by LPS.
Experimental approach:
The biological activities of α‐humulene and trans‐caryophyllene were investigated in a model of acute inflammation in rat paw, induced by LPS and characterized by paw oedema, neutrophil recruitment, cytokine production, activation of MAP kinases and NF‐κB and up‐regulated expression of kinin B1 receptors.
Key results:
Treatment with either α‐humulene or trans‐caryophyllene effectively reduced neutrophil migration and activation of NF‐κB induced by LPS in the rat paw. However, only α‐humulene significantly reduced the increase in TNF‐α and IL‐1β levels, paw oedema and the up‐regulation of B1 receptors following treatment with LPS. Both compounds failed to interfere with the activation of the MAP kinases, ERK, p38 and JNK.
Conclusions and Implications:
Both α‐humulene and trans‐caryophyllene inhibit the LPS‐induced NF‐κB activation and neutrophil migration, although only α‐humulene had the ability to prevent the production of pro‐inflammatory cytokines TNF‐α and IL‐1β and the in vivo up‐regulation of kinin B1 receptors. These data provide additional molecular and functional insights into the beneficial effects of the sesquiterpenes α‐humulene and trans‐caryophyllene isolated from the essential oil of Cordia verbenacea as agents for the management of inflammatory diseases.
British Journal of Pharmacology (2007) 151, 618–627; doi:10.1038/sj.bjp.0707270</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0707270</identifier><identifier>PMID: 17471174</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal ; B1 receptor ; Biological and medical sciences ; Blotting, Western ; bradykinin ; Cell Nucleus - drug effects ; Cell Nucleus - metabolism ; Cordia ; Cordia - chemistry ; Cordia verbenacea ; Cytosol - drug effects ; Cytosol - metabolism ; Edema - chemically induced ; Edema - pathology ; Edema - prevention & control ; Electrophoretic Mobility Shift Assay ; Foot - pathology ; inflammation ; Interleukin-1beta - biosynthesis ; lipopolysaccharide ; Lipopolysaccharides ; Male ; MAP kinases ; Medical sciences ; Mitogen-Activated Protein Kinases - metabolism ; Neutrophil Infiltration - drug effects ; Neutrophils - drug effects ; Neutrophils - enzymology ; NF-kappa B - metabolism ; nuclear factor‐κB ; Oils, Volatile - pharmacology ; Peroxidase - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Receptor, Bradykinin B1 - drug effects ; Research Papers ; Reverse Transcriptase Polymerase Chain Reaction ; Sesquiterpenes - pharmacology ; trans‐caryophyllene ; Tumor Necrosis Factor-alpha - biosynthesis ; Up-Regulation - drug effects ; α‐humulene</subject><ispartof>British journal of pharmacology, 2007-07, Vol.151 (5), p.618-627</ispartof><rights>2007 British Pharmacological Society</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jul 2007</rights><rights>Copyright 2007, Nature Publishing Group 2007 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5195-4d1b0b0e4f4aa8c526a92480e714cc2dc6171d4a9df9e2b5d63910063d2e49f63</citedby><cites>FETCH-LOGICAL-c5195-4d1b0b0e4f4aa8c526a92480e714cc2dc6171d4a9df9e2b5d63910063d2e49f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013990/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013990/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18898703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17471174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Medeiros, R</creatorcontrib><creatorcontrib>Passos, G F</creatorcontrib><creatorcontrib>Vitor, C E</creatorcontrib><creatorcontrib>Koepp, J</creatorcontrib><creatorcontrib>Mazzuco, T L</creatorcontrib><creatorcontrib>Pianowski, L F</creatorcontrib><creatorcontrib>Campos, M M</creatorcontrib><creatorcontrib>Calixto, J B</creatorcontrib><title>Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Background and purpose:
α‐Humulene and trans‐caryophyllene are sesquiterpene compounds identified in the essential oil of Cordia verbenacea which display topical and systemic anti‐inflammatory effects in different experimental models. However, the molecular mechanisms through which they exert their anti‐inflammatory activity still remain unclear. Here, we evaluate the effects of α‐humulene and trans‐caryophyllene on the acute inflammatory responses elicited by LPS.
Experimental approach:
The biological activities of α‐humulene and trans‐caryophyllene were investigated in a model of acute inflammation in rat paw, induced by LPS and characterized by paw oedema, neutrophil recruitment, cytokine production, activation of MAP kinases and NF‐κB and up‐regulated expression of kinin B1 receptors.
Key results:
Treatment with either α‐humulene or trans‐caryophyllene effectively reduced neutrophil migration and activation of NF‐κB induced by LPS in the rat paw. However, only α‐humulene significantly reduced the increase in TNF‐α and IL‐1β levels, paw oedema and the up‐regulation of B1 receptors following treatment with LPS. Both compounds failed to interfere with the activation of the MAP kinases, ERK, p38 and JNK.
Conclusions and Implications:
Both α‐humulene and trans‐caryophyllene inhibit the LPS‐induced NF‐κB activation and neutrophil migration, although only α‐humulene had the ability to prevent the production of pro‐inflammatory cytokines TNF‐α and IL‐1β and the in vivo up‐regulation of kinin B1 receptors. These data provide additional molecular and functional insights into the beneficial effects of the sesquiterpenes α‐humulene and trans‐caryophyllene isolated from the essential oil of Cordia verbenacea as agents for the management of inflammatory diseases.
British Journal of Pharmacology (2007) 151, 618–627; doi:10.1038/sj.bjp.0707270</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal</subject><subject>B1 receptor</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>bradykinin</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Cordia</subject><subject>Cordia - chemistry</subject><subject>Cordia verbenacea</subject><subject>Cytosol - drug effects</subject><subject>Cytosol - metabolism</subject><subject>Edema - chemically induced</subject><subject>Edema - pathology</subject><subject>Edema - prevention & control</subject><subject>Electrophoretic Mobility Shift Assay</subject><subject>Foot - pathology</subject><subject>inflammation</subject><subject>Interleukin-1beta - biosynthesis</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>MAP kinases</subject><subject>Medical sciences</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Neutrophil Infiltration - drug effects</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - enzymology</subject><subject>NF-kappa B - metabolism</subject><subject>nuclear factor‐κB</subject><subject>Oils, Volatile - pharmacology</subject><subject>Peroxidase - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Bradykinin B1 - drug effects</subject><subject>Research Papers</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sesquiterpenes - pharmacology</subject><subject>trans‐caryophyllene</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Up-Regulation - drug effects</subject><subject>α‐humulene</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFks2O0zAUhS0EYkphyxJZSLBLsR0nTjZIQzUwSJUYCVhbN8414yqJg5206ovwvLjTigE2s7EX9zvn_ugQ8pKzFWd59S5uV812XDHFlFDsEVlwqcqsyCv-mCwYYyrjvKouyLMYt4yloiqekguupOLpWZBfV9aimai3dNp7CmZyO6TG96OfhzZS30zgBmypDb6n0y1SjBGHyUFHveuOurUPrQO6w9DgAAaB-uGOBDNPSN1gO-h7mHw40IBx9EPESLFzxk3JuDnQzc3XhN1pAkx0hP1z8sRCF_HF-V-S7x-vvq2vs82XT5_Xl5vMFLwuMtnyhjUMpZUAlSlECbWQFUPFpTGiNSVXvJVQt7ZG0RRtmdecsTJvBcralvmSvD_5jnPTY2vSZgE6PQbXQzhoD07_Wxncrf7hd1owntc1SwZvzwbB_5wxTrp30WDXwYB-jlqxskijlg-CgolS1ezo-Po_cOvnMKQraMGV4Fym1kuyOkEm-BgD2j8jc6aPwdBxq1Mw9DkYSfDq70Xv8XMSEvDmDEA00NkAg3Hxnququko-iRMnbu86PDzQVn-4uZayyH8D0sfT-w</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Medeiros, R</creator><creator>Passos, G F</creator><creator>Vitor, C E</creator><creator>Koepp, J</creator><creator>Mazzuco, T L</creator><creator>Pianowski, L F</creator><creator>Campos, M M</creator><creator>Calixto, J B</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200707</creationdate><title>Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw</title><author>Medeiros, R ; Passos, G F ; Vitor, C E ; Koepp, J ; Mazzuco, T L ; Pianowski, L F ; Campos, M M ; Calixto, J B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5195-4d1b0b0e4f4aa8c526a92480e714cc2dc6171d4a9df9e2b5d63910063d2e49f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal</topic><topic>B1 receptor</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>bradykinin</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - metabolism</topic><topic>Cordia</topic><topic>Cordia - chemistry</topic><topic>Cordia verbenacea</topic><topic>Cytosol - drug effects</topic><topic>Cytosol - metabolism</topic><topic>Edema - chemically induced</topic><topic>Edema - pathology</topic><topic>Edema - prevention & control</topic><topic>Electrophoretic Mobility Shift Assay</topic><topic>Foot - pathology</topic><topic>inflammation</topic><topic>Interleukin-1beta - biosynthesis</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>MAP kinases</topic><topic>Medical sciences</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Neutrophil Infiltration - drug effects</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - enzymology</topic><topic>NF-kappa B - metabolism</topic><topic>nuclear factor‐κB</topic><topic>Oils, Volatile - pharmacology</topic><topic>Peroxidase - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Bradykinin B1 - drug effects</topic><topic>Research Papers</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sesquiterpenes - pharmacology</topic><topic>trans‐caryophyllene</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Up-Regulation - drug effects</topic><topic>α‐humulene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medeiros, R</creatorcontrib><creatorcontrib>Passos, G F</creatorcontrib><creatorcontrib>Vitor, C E</creatorcontrib><creatorcontrib>Koepp, J</creatorcontrib><creatorcontrib>Mazzuco, T L</creatorcontrib><creatorcontrib>Pianowski, L F</creatorcontrib><creatorcontrib>Campos, M M</creatorcontrib><creatorcontrib>Calixto, J B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medeiros, R</au><au>Passos, G F</au><au>Vitor, C E</au><au>Koepp, J</au><au>Mazzuco, T L</au><au>Pianowski, L F</au><au>Campos, M M</au><au>Calixto, J B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2007-07</date><risdate>2007</risdate><volume>151</volume><issue>5</issue><spage>618</spage><epage>627</epage><pages>618-627</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>Background and purpose:
α‐Humulene and trans‐caryophyllene are sesquiterpene compounds identified in the essential oil of Cordia verbenacea which display topical and systemic anti‐inflammatory effects in different experimental models. However, the molecular mechanisms through which they exert their anti‐inflammatory activity still remain unclear. Here, we evaluate the effects of α‐humulene and trans‐caryophyllene on the acute inflammatory responses elicited by LPS.
Experimental approach:
The biological activities of α‐humulene and trans‐caryophyllene were investigated in a model of acute inflammation in rat paw, induced by LPS and characterized by paw oedema, neutrophil recruitment, cytokine production, activation of MAP kinases and NF‐κB and up‐regulated expression of kinin B1 receptors.
Key results:
Treatment with either α‐humulene or trans‐caryophyllene effectively reduced neutrophil migration and activation of NF‐κB induced by LPS in the rat paw. However, only α‐humulene significantly reduced the increase in TNF‐α and IL‐1β levels, paw oedema and the up‐regulation of B1 receptors following treatment with LPS. Both compounds failed to interfere with the activation of the MAP kinases, ERK, p38 and JNK.
Conclusions and Implications:
Both α‐humulene and trans‐caryophyllene inhibit the LPS‐induced NF‐κB activation and neutrophil migration, although only α‐humulene had the ability to prevent the production of pro‐inflammatory cytokines TNF‐α and IL‐1β and the in vivo up‐regulation of kinin B1 receptors. These data provide additional molecular and functional insights into the beneficial effects of the sesquiterpenes α‐humulene and trans‐caryophyllene isolated from the essential oil of Cordia verbenacea as agents for the management of inflammatory diseases.
British Journal of Pharmacology (2007) 151, 618–627; doi:10.1038/sj.bjp.0707270</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17471174</pmid><doi>10.1038/sj.bjp.0707270</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 2007-07, Vol.151 (5), p.618-627 |
| issn | 0007-1188 1476-5381 |
| language | eng |
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| source | PubMed Central Free; MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal B1 receptor Biological and medical sciences Blotting, Western bradykinin Cell Nucleus - drug effects Cell Nucleus - metabolism Cordia Cordia - chemistry Cordia verbenacea Cytosol - drug effects Cytosol - metabolism Edema - chemically induced Edema - pathology Edema - prevention & control Electrophoretic Mobility Shift Assay Foot - pathology inflammation Interleukin-1beta - biosynthesis lipopolysaccharide Lipopolysaccharides Male MAP kinases Medical sciences Mitogen-Activated Protein Kinases - metabolism Neutrophil Infiltration - drug effects Neutrophils - drug effects Neutrophils - enzymology NF-kappa B - metabolism nuclear factor‐κB Oils, Volatile - pharmacology Peroxidase - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Receptor, Bradykinin B1 - drug effects Research Papers Reverse Transcriptase Polymerase Chain Reaction Sesquiterpenes - pharmacology trans‐caryophyllene Tumor Necrosis Factor-alpha - biosynthesis Up-Regulation - drug effects α‐humulene |
| title | Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T02%3A41%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20two%20active%20compounds%20obtained%20from%20the%20essential%20oil%20of%20Cordia%20verbenacea%20on%20the%20acute%20inflammatory%20responses%20elicited%20by%20LPS%20in%20the%20rat%20paw&rft.jtitle=British%20journal%20of%20pharmacology&rft.au=Medeiros,%20R&rft.date=2007-07&rft.volume=151&rft.issue=5&rft.spage=618&rft.epage=627&rft.pages=618-627&rft.issn=0007-1188&rft.eissn=1476-5381&rft.coden=BJPCBM&rft_id=info:doi/10.1038/sj.bjp.0707270&rft_dat=%3Cproquest_pubme%3E1298100661%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217211401&rft_id=info:pmid/17471174&rfr_iscdi=true |