NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1
Neuronal development requires several discrete morphological steps that are believed to involve the small GTPase Rac. For example, neural activity, through NMDA receptors and/or AMPA receptors, activates Rac leading to elaboration of dendritic arbors. In the current study, we have conducted studies...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2006-05, Vol.343 (2), p.504-512 |
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| creator | Tejada-Simon, Maria V. Villasana, Laura E. Serrano, Faridis Klann, Eric |
| description | Neuronal development requires several discrete morphological steps that are believed to involve the small GTPase Rac. For example, neural activity, through NMDA receptors and/or AMPA receptors, activates Rac leading to elaboration of dendritic arbors. In the current study, we have conducted studies which indicate that Rac might be an important molecule involved in morphological plasticity in the adult mouse. We demonstrate that Rac is expressed at synapses in the adult mouse hippocampus. We also demonstrate that treatment of hippocampal slices with NMDA induces membrane translocation and activation of Rac in area CA1. Interestingly, we also find that there is an increase in Rac that is associated with NMDA receptor complexes following NMDA receptor activation. Taken together, our data are consistent with the idea that Rac could be participating in NMDA receptor-dependent changes in morphology that occur during synaptic plasticity and memory formation in the adult mouse hippocampus. |
| doi_str_mv | 10.1016/j.bbrc.2006.02.183 |
| format | Article |
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Taken together, our data are consistent with the idea that Rac could be participating in NMDA receptor-dependent changes in morphology that occur during synaptic plasticity and memory formation in the adult mouse hippocampus.</description><subject>Animals</subject><subject>CA1</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - metabolism</subject><subject>Cells, Cultured</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Learning</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>N-Methylaspartate - pharmacology</subject><subject>Protein Transport - drug effects</subject><subject>Protein Transport - physiology</subject><subject>rac GTP-Binding Proteins - metabolism</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Rho subfamily</subject><subject>Small GTP-binding proteins</subject><subject>Synaptic plasticity</subject><subject>Tissue Distribution</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhS0EYsvCH-CAfOKW7IzdOImEkKousEgLSGgP3CzHnrCukjjYaSX-Pa5awXKBk6WZb57nzWPsJUKJgOpqV3ZdtKUAUCWIEhv5iK0QWigEwvoxW0HuFKLFbxfsWUo7AMS1ap-yC1TVWqFQK9Z9_nS94ZEszUuI3NjFH8ziw8T95PaWEl-imdIQ7KlqJvcQCj3_amxm-Rj2ifi9n-eMjrMZuIlk-HaDz9mT3gyJXpzfS3b3_t3d9qa4_fLh43ZzW9iqgqWQgGSbVlhhFPWuA6MU2LbJJqAytWxsXUlJda62ymFvKjBridQp50BJecnenmTnfTeSszTlzQc9Rz-a-FMH4_Xfncnf6-_hoAWgzJ9ngddngRh-7CktevTJ0jCYibI5req6aVvxfxBrbISQdQbFCbQxpBSp_70Ngj5GqHf6GKE-RqhB6BxhHnr10MefkXNmGXhzAigf8-Ap6mQ9TZaczzku2gX_L_1f4hqt4A</recordid><startdate>20060505</startdate><enddate>20060505</enddate><creator>Tejada-Simon, Maria V.</creator><creator>Villasana, Laura E.</creator><creator>Serrano, Faridis</creator><creator>Klann, Eric</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060505</creationdate><title>NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1</title><author>Tejada-Simon, Maria V. ; Villasana, Laura E. ; Serrano, Faridis ; Klann, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-301ec892c2a6efdb0a660c9800005a738c7533e766096d1fa50a431eb6dd0633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>CA1</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - metabolism</topic><topic>Cells, Cultured</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Learning</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Protein Transport - drug effects</topic><topic>Protein Transport - physiology</topic><topic>rac GTP-Binding Proteins - metabolism</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>Rho subfamily</topic><topic>Small GTP-binding proteins</topic><topic>Synaptic plasticity</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tejada-Simon, Maria V.</creatorcontrib><creatorcontrib>Villasana, Laura E.</creatorcontrib><creatorcontrib>Serrano, Faridis</creatorcontrib><creatorcontrib>Klann, Eric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tejada-Simon, Maria V.</au><au>Villasana, Laura E.</au><au>Serrano, Faridis</au><au>Klann, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2006-05-05</date><risdate>2006</risdate><volume>343</volume><issue>2</issue><spage>504</spage><epage>512</epage><pages>504-512</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Neuronal development requires several discrete morphological steps that are believed to involve the small GTPase Rac. 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| subjects | Animals CA1 Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Hippocampus - drug effects Hippocampus - metabolism Learning Male Mice Mice, Inbred C57BL N-Methylaspartate - pharmacology Protein Transport - drug effects Protein Transport - physiology rac GTP-Binding Proteins - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Rho subfamily Small GTP-binding proteins Synaptic plasticity Tissue Distribution |
| title | NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1 |
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