Differences in proliferative activity of rat and human prostate in culture
The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. Quantitative methods were used to assess changes in tissue composition and the height of the epithelial cells. BPH appeared less sensitive than rat pros...
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| Veröffentlicht in: | British journal of cancer 1975-05, Vol.31 (5), p.570-580 |
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| container_end_page | 580 |
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| container_title | British journal of cancer |
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| creator | Shipman, P A Littlewood, V Riches, A C Thomas, G H |
| description | The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. Quantitative methods were used to assess changes in tissue composition and the height of the epithelial cells. BPH appeared less sensitive than rat prostate to withdrawal of hormone support, and the changes which occurred during culture of BPH were more typical of a repair mechanism to injury than of a castration effect. Cell kinetics was investigated using [125I] iododeoxyuridine and vincristine. Both approaches demonstrated a spontaneous surge in proliferative activity of BPH reaching a peak at about Day 4. In contrast, proliferative activity in rat prostate tended to fall over the period of 2-8 days of culture. The significance of these findings in terms of age linked effects is discussed. |
| doi_str_mv | 10.1038/bjc.1975.98 |
| format | Article |
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The significance of these findings in terms of age linked effects is discussed.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1975.98</identifier><identifier>PMID: 50856</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Age Factors ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell Differentiation ; Cell Division - drug effects ; Drug Resistance ; Epidemiology ; Humans ; Insulin - pharmacology ; Kinetics ; Male ; Molecular Medicine ; Oncology ; Organ Culture Techniques ; original-article ; Prostate - cytology ; Prostatic Hyperplasia - pathology ; Rats ; Testosterone - pharmacology</subject><ispartof>British journal of cancer, 1975-05, Vol.31 (5), p.570-580</ispartof><rights>Cancer Research Campaign 1975</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-924b5ff388b767b6cd2e5b54f336f57231515dfb17e4c9cd67802d6b834e84213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009448/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009448/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/50856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shipman, P A</creatorcontrib><creatorcontrib>Littlewood, V</creatorcontrib><creatorcontrib>Riches, A C</creatorcontrib><creatorcontrib>Thomas, G H</creatorcontrib><title>Differences in proliferative activity of rat and human prostate in culture</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. Quantitative methods were used to assess changes in tissue composition and the height of the epithelial cells. BPH appeared less sensitive than rat prostate to withdrawal of hormone support, and the changes which occurred during culture of BPH were more typical of a repair mechanism to injury than of a castration effect. Cell kinetics was investigated using [125I] iododeoxyuridine and vincristine. Both approaches demonstrated a spontaneous surge in proliferative activity of BPH reaching a peak at about Day 4. In contrast, proliferative activity in rat prostate tended to fall over the period of 2-8 days of culture. The significance of these findings in terms of age linked effects is discussed.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell Differentiation</subject><subject>Cell Division - drug effects</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Insulin - pharmacology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Organ Culture Techniques</subject><subject>original-article</subject><subject>Prostate - cytology</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Rats</subject><subject>Testosterone - pharmacology</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkL1PwzAUxC1EBaUwMbJkYoEU24ljZ0FC5VuVWGC2HOe5dZUmxU4q9b_HaasKJKYn353Pfj-ELgkeE5yIu2KhxyTnbJyLIzQkLKExEZQfoyHGmMc4p_gUnXm_CMccC36CBgwLlg3R-6M1BhzUGnxk62jlmsoGQbV2DZHSYdh2EzUmClKk6jKad0u1zflWtdDf0V3Vdg7O0cCoysPFfo7Q1_PT5-Q1nn68vE0eprFOCWnjnKYFMyYRouAZLzJdUmAFS02SZIZxmhBGWGkKwiHVuS4zLjAts0IkKYiUkmSE7ne9q65YQqmhbp2q5MrZpXIb2Sgr_zq1nctZs5Y0LJ-mIhRc7wtc892Bb-XSeg1VpWpoOi8FDTFOeQje7II6bOsdmMMjBMsevAzgZQ9e5n3t1e9_HbJb0sG93bk-6PUMnFw0nasDqH_LfgBgrI5i</recordid><startdate>19750501</startdate><enddate>19750501</enddate><creator>Shipman, P A</creator><creator>Littlewood, V</creator><creator>Riches, A C</creator><creator>Thomas, G H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19750501</creationdate><title>Differences in proliferative activity of rat and human prostate in culture</title><author>Shipman, P A ; Littlewood, V ; Riches, A C ; Thomas, G H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-924b5ff388b767b6cd2e5b54f336f57231515dfb17e4c9cd67802d6b834e84213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell Differentiation</topic><topic>Cell Division - drug effects</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Insulin - pharmacology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Organ Culture Techniques</topic><topic>original-article</topic><topic>Prostate - cytology</topic><topic>Prostatic Hyperplasia - pathology</topic><topic>Rats</topic><topic>Testosterone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shipman, P A</creatorcontrib><creatorcontrib>Littlewood, V</creatorcontrib><creatorcontrib>Riches, A C</creatorcontrib><creatorcontrib>Thomas, G H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shipman, P A</au><au>Littlewood, V</au><au>Riches, A C</au><au>Thomas, G H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in proliferative activity of rat and human prostate in culture</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1975-05-01</date><risdate>1975</risdate><volume>31</volume><issue>5</issue><spage>570</spage><epage>580</epage><pages>570-580</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. 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| ispartof | British journal of cancer, 1975-05, Vol.31 (5), p.570-580 |
| issn | 0007-0920 1532-1827 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Age Factors Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell Differentiation Cell Division - drug effects Drug Resistance Epidemiology Humans Insulin - pharmacology Kinetics Male Molecular Medicine Oncology Organ Culture Techniques original-article Prostate - cytology Prostatic Hyperplasia - pathology Rats Testosterone - pharmacology |
| title | Differences in proliferative activity of rat and human prostate in culture |
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