The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice
The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lym...
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| Veröffentlicht in: | British journal of cancer 1975-01, Vol.31 (1), p.100-110 |
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| container_end_page | 110 |
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| container_title | British journal of cancer |
| container_volume | 31 |
| creator | Franks, C R Perkins, F T Bshop, D |
| description | The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lymphopenia which was vary rapid in onset. Concurrent with the lymphopenia there was prolongation of HeLa tumour nodule growth in female mice, but not in males. A lymphopenia occurred in androgen treated male mice with subsequent prolongation of HeLa tumour nodule growth, and a lymphocytosis in female mice, with reduction of HeLa tumour nodule growth. |
| doi_str_mv | 10.1038/bjc.1975.12 |
| format | Article |
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It was found that oestrogen treated male and female mice experienced a profound lymphopenia which was vary rapid in onset. Concurrent with the lymphopenia there was prolongation of HeLa tumour nodule growth in female mice, but not in males. A lymphopenia occurred in androgen treated male mice with subsequent prolongation of HeLa tumour nodule growth, and a lymphocytosis in female mice, with reduction of HeLa tumour nodule growth.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1975.12</identifier><identifier>PMID: 1080423</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Drug Resistance ; Epidemiology ; Estradiol - pharmacology ; Female ; Gonadal Steroid Hormones - pharmacology ; HeLa Cells ; Immunity, Cellular - drug effects ; In Vitro Techniques ; Leukocyte Count ; Lymphocytes - drug effects ; Lymphocytosis - chemically induced ; Lymphopenia - chemically induced ; Male ; Mice ; Mice, Inbred CBA ; Molecular Medicine ; Neoplasms, Experimental - immunology ; Oncology ; original-article ; Sex Factors ; T-Lymphocytes - drug effects ; Testosterone - pharmacology</subject><ispartof>British journal of cancer, 1975-01, Vol.31 (1), p.100-110</ispartof><rights>Cancer Research Campaign 1975</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-576c19b62bbfafdc3923ae06d3c83958ce2179f89d521ee78eb83a628a70044d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009362/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009362/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1080423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franks, C R</creatorcontrib><creatorcontrib>Perkins, F T</creatorcontrib><creatorcontrib>Bshop, D</creatorcontrib><title>The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lymphopenia which was vary rapid in onset. Concurrent with the lymphopenia there was prolongation of HeLa tumour nodule growth in female mice, but not in males. A lymphopenia occurred in androgen treated male mice with subsequent prolongation of HeLa tumour nodule growth, and a lymphocytosis in female mice, with reduction of HeLa tumour nodule growth.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Gonadal Steroid Hormones - pharmacology</subject><subject>HeLa Cells</subject><subject>Immunity, Cellular - drug effects</subject><subject>In Vitro Techniques</subject><subject>Leukocyte Count</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytosis - chemically induced</subject><subject>Lymphopenia - chemically induced</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Molecular Medicine</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Oncology</subject><subject>original-article</subject><subject>Sex Factors</subject><subject>T-Lymphocytes - drug effects</subject><subject>Testosterone - pharmacology</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLAzEURoMotVZXroXsdWoe88hsBClqhYKbisuQydx0pnSSkpnx8e_NtCIVXOWG893vwkHokpIpJVzcFms9pXmWTCk7QmOacBZRwbJjNCaEZBHJGTlFZ227Dt-ciGyERpQIEjM-Rm_LCjAYA7rDzuAWPnHlfOMstNhZ3AW68u6jqwY6h4XCXd-43mPryn4TQrXFjdoAVrbEBnZjU2s4RydGbVq4-Hkn6PXxYTmbR4uXp-fZ_SLSMeVdlGSppnmRsqIwypSa54wrIGnJteB5IjQwmuVG5GXCKEAmoBBcpUyojJA4LvkE3e17t33RQKnBdl5t5NbXjfJf0qla_iW2ruTKvUsWXPCUhYLrfYH2rm09mN9dSuSgVwa9ctAr6ZC-Ojx3kN35DPxmz9tA7Aq8XAdZNhj4t-4bC6GFdA</recordid><startdate>19750101</startdate><enddate>19750101</enddate><creator>Franks, C R</creator><creator>Perkins, F T</creator><creator>Bshop, D</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19750101</creationdate><title>The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice</title><author>Franks, C R ; Perkins, F T ; Bshop, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-576c19b62bbfafdc3923ae06d3c83958ce2179f89d521ee78eb83a628a70044d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Gonadal Steroid Hormones - pharmacology</topic><topic>HeLa Cells</topic><topic>Immunity, Cellular - drug effects</topic><topic>In Vitro Techniques</topic><topic>Leukocyte Count</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytosis - chemically induced</topic><topic>Lymphopenia - chemically induced</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Molecular Medicine</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Oncology</topic><topic>original-article</topic><topic>Sex Factors</topic><topic>T-Lymphocytes - drug effects</topic><topic>Testosterone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franks, C R</creatorcontrib><creatorcontrib>Perkins, F T</creatorcontrib><creatorcontrib>Bshop, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franks, C R</au><au>Perkins, F T</au><au>Bshop, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1975-01-01</date><risdate>1975</risdate><volume>31</volume><issue>1</issue><spage>100</spage><epage>110</epage><pages>100-110</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lymphopenia which was vary rapid in onset. Concurrent with the lymphopenia there was prolongation of HeLa tumour nodule growth in female mice, but not in males. A lymphopenia occurred in androgen treated male mice with subsequent prolongation of HeLa tumour nodule growth, and a lymphocytosis in female mice, with reduction of HeLa tumour nodule growth.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1080423</pmid><doi>10.1038/bjc.1975.12</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 1975-01, Vol.31 (1), p.100-110 |
| issn | 0007-0920 1532-1827 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Estradiol - pharmacology Female Gonadal Steroid Hormones - pharmacology HeLa Cells Immunity, Cellular - drug effects In Vitro Techniques Leukocyte Count Lymphocytes - drug effects Lymphocytosis - chemically induced Lymphopenia - chemically induced Male Mice Mice, Inbred CBA Molecular Medicine Neoplasms, Experimental - immunology Oncology original-article Sex Factors T-Lymphocytes - drug effects Testosterone - pharmacology |
| title | The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice |
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