An electron and fluorescence microscopic study of LLC-PK1 cells, a kidney epithelial cell line: normal morphology and cyclosporin A- and cremophor-induced alterations

The present study demonstrates the following: (I) At high concentrations cyclosporin A is toxic to LLC-PK1 cells and at intermediate concentrations also alters intracellular morphology in this same system. Even though these cells differ morphologically from renal cortex in a number of ways, the morp...

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Veröffentlicht in:	International journal of experimental pathology 1991-08, Vol.72 (4), p.365-378
Hauptverfasser:	Nässberger, L, Bergstrand, A, DePierre, J W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cyclosporins - pharmacology Epithelium - ultrastructure Kidney - drug effects Kidney - ultrastructure Microscopy, Electron Microscopy, Fluorescence Oxazines Pharmaceutical Vehicles - pharmacology Polyethylene Glycols - pharmacology Swine
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