Detection of somatic changes in human cancer DNA by DNA fingerprint analysis
Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA...
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| Veröffentlicht in: | British journal of cancer 1987-04, Vol.55 (4), p.353-356 |
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| container_issue | 4 |
| container_start_page | 353 |
| container_title | British journal of cancer |
| container_volume | 55 |
| creator | Thein, SL Jeffreys, AJ Gooi, HC Cotter, F Flint, J O'Connor, NTJ Weatherall, DJ Wainscoat, JS |
| description | Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 cases. The changes included alterations in the relative intensities of hybridising DNA fragments, and, in three cases of cancers of gastrointestinal origin, the appearance of novel minisatellite fragments not seen in the corresponding constitutional DNA. The results of this preliminary study suggests that DNA fingerprint analysis provides a useful technique for identifying somatic changes in cancers. |
| doi_str_mv | 10.1038/bjc.1987.71 |
| format | Article |
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Somatic changes were seen in the tumour DNA in ten of the 35 cases. The changes included alterations in the relative intensities of hybridising DNA fragments, and, in three cases of cancers of gastrointestinal origin, the appearance of novel minisatellite fragments not seen in the corresponding constitutional DNA. The results of this preliminary study suggests that DNA fingerprint analysis provides a useful technique for identifying somatic changes in cancers.</description><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer Research</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>DNA, Neoplasm - analysis</subject><subject>DNA, Satellite</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>experimental-oncology</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - genetics</subject><subject>General aspects</subject><subject>Humans</subject><subject>Lymphoma - genetics</subject><subject>Medical sciences</subject><subject>Molecular Medicine</subject><subject>Mutation</subject><subject>Nucleic Acid Hybridization</subject><subject>Nucleotide Mapping</subject><subject>Oncogenes</subject><subject>Oncology</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EWsrCiTMiB8QFUjxxHduXlVa7fEkVXOBsTRx76yqxFztB6r_HoVUFB8RpZM2jd2b8EPIc6Book--6vVmDkmIt4AFZAWdNDbIRD8mKUipqqhr6mDzJeV-eikpxQS4Yl7Rp6Ypsb-1kzeRjqKKrchxx8qYyOwx3Nlc-VLt5xFAZDMam6vbLddUdfhfnC5Hukw9ThQGHQ_b5KXnkcMj22aleku8f3n-7-VRvv378fHO9rQ1v2VQj4xtsmeiYLMu2gMqxhvfQN2Aocx1I3vSOG2tQYScBZS-E4z061UsLkl2Sq2Pu_dyNtjc2TAkHXZYZMR10RK__7gS_03fxp24oBQFQAl6fAlL8Mds86dFnY4cBg41z1kJwUIr_H4SNgg2HTQHfHEGTYs7JuvM2QPViSRdLerGkxRL74s8DzuxJS-m_OvUxGxxcKt_v8xmTIFvOl6Fvj1hePBQdeh_nVGTkf0x9ecQDTnOy57jCLEghfgGzubPm</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>Thein, SL</creator><creator>Jeffreys, AJ</creator><creator>Gooi, HC</creator><creator>Cotter, F</creator><creator>Flint, J</creator><creator>O'Connor, NTJ</creator><creator>Weatherall, DJ</creator><creator>Wainscoat, JS</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19870401</creationdate><title>Detection of somatic changes in human cancer DNA by DNA fingerprint analysis</title><author>Thein, SL ; 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| ispartof | British journal of cancer, 1987-04, Vol.55 (4), p.353-356 |
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| language | eng |
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| source | MEDLINE; Nature; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast Neoplasms - genetics Cancer Research Carcinogenesis, carcinogens and anticarcinogens DNA, Neoplasm - analysis DNA, Satellite Drug Resistance Epidemiology experimental-oncology Female Gastrointestinal Neoplasms - genetics General aspects Humans Lymphoma - genetics Medical sciences Molecular Medicine Mutation Nucleic Acid Hybridization Nucleotide Mapping Oncogenes Oncology Tumors |
| title | Detection of somatic changes in human cancer DNA by DNA fingerprint analysis |
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