IκB kinase α kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

NF-κB is constitutively active in many solid tumors, including breast cancer. However, the role of NF-κB in breast carcinogenesis is unknown. IkkαAA/AA "knockin" mice in which activation of IκB kinase α (IKKα) is prevented by replacement of activation loop serines with alanines exhibit del...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-10, Vol.104 (40), p.15852-15857
Hauptverfasser:	Cao, Yixue, Luo, Jun-li, Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Breast cancer Cancer Carcinogenesis Carcinoma Cell growth Cultured cells Cyclins Epithelial cells Mammary glands Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!