SIRT1 controls endothelial angiogenic functions during vascular growth

The nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase Sir2 regulates life-span in various species. Mammalian homologs of Sir2 are called sirtuins (SIRT1-SIRT7). In an effort to define the role of sirtuins in vascular homeostasis, we found that among the SIRT family, SIRT1 uniq...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2007-10, Vol.21 (20), p.2644-2658
Hauptverfasser:	Potente, Michael, Ghaeni, Laleh, Baldessari, Danila, Mostoslavsky, Raul, Rossig, Lothar, Dequiedt, Franck, Haendeler, Judith, Mione, Marina, Dejana, Elisabetta, Alt, Frederick W, Zeiher, Andreas M, Dimmeler, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation angiogenesis Animals Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Blood Vessels - growth & development Cells, Cultured chromatin Endothelial Cells - cytology Endothelial Cells - physiology Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism Gene Expression Regulation, Developmental hdac Humans Life sciences Mice Mice, Knockout Mice, Mutant Strains Mice, Transgenic Morphogenesis Neovascularization, Physiologic - genetics Research Paper RNA Interference Sciences du vivant sir2 Sirtuin 1 Sirtuins - deficiency Sirtuins - genetics Sirtuins - physiology transcription Zebrafish
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!