Peutz–Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment

Peutz-Jeghers syndrome (PJS) is an autosomal dominant cancer susceptibility syndrome characterised by mucocutaneous melanin pigmentation, hamartomatous polyps, and an 18-fold increase in intestinal and extraintestinal cancer risk. 1 PJS is caused by a germline mutation in LKB1, a gene that plays a r...

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Veröffentlicht in:	Gut 2007-10, Vol.56 (10), p.1475-1476
Hauptverfasser:	de Leng, W W J, Jansen, M, Keller, J J, de Gijsel, M, Milne, A N A, Morsink, F H M, Weterman, M A J, Iacobuzio-Donahue, C A, Clevers, H C, Giardiello, F M, Offerhaus, G J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell division Female Germ-Line Mutation - genetics Humans Intestinal Mucosa - pathology Labeling Letters Mitotic Index Mutation Peutz-Jeghers Syndrome - genetics Peutz-Jeghers Syndrome - pathology Peutz–Jeghers syndrome polyclonal expansion polyp Protein-Serine-Threonine Kinases - genetics Receptors, Androgen - genetics Stem cells Stem Cells - pathology Surveillance
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