The effect of Kupffer cell elimination on ethanol-induced liver damage in mice
C57BL/10 mice develop inflammatory and necrotic changes in the liver, as well as raised serum ALT activities, after 9 days of exposure to ethanol vapour. If mice were injected twice with liposomes containing dichloromethylene diphosphonate (DMDP), with an interval of 5 days between the injections, t...
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| Veröffentlicht in: | International journal of experimental pathology 1995-10, Vol.76 (5), p.353-359 |
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| container_title | International journal of experimental pathology |
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| creator | GOLDIN, R. D RATNAYAKA, I. D BROWN, I. N WICKRAMASINGHE, S. N |
| description | C57BL/10 mice develop inflammatory and necrotic changes in the liver, as well as raised serum ALT activities, after 9 days of exposure to ethanol vapour. If mice were injected twice with liposomes containing dichloromethylene diphosphonate (DMDP), with an interval of 5 days between the injections, there was complete elimination of Kupffer cells (hepatic macrophages) for a 9-day period starting 1 day after the first injection. The inflammatory and necrotic changes were significantly reduced in mice injected with liposomes containing DMDP as compared to uninjected mice or mice injected with empty liposomes; serum ALT activities were also significantly reduced. No significant difference was seen in serum tumour necrosis factor-alpha levels between the different groups. Kupffer cells therefore play a significant role in the development of the liver damage resulting from exposure to ethanol. Acetaldehyde production by Kupffer cells is one way in which these cells can damage hepatocytes and further work needs to be done to investigate this and other mechanisms. |
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D ; RATNAYAKA, I. D ; BROWN, I. N ; WICKRAMASINGHE, S. N</creator><creatorcontrib>GOLDIN, R. D ; RATNAYAKA, I. D ; BROWN, I. N ; WICKRAMASINGHE, S. N</creatorcontrib><description>C57BL/10 mice develop inflammatory and necrotic changes in the liver, as well as raised serum ALT activities, after 9 days of exposure to ethanol vapour. If mice were injected twice with liposomes containing dichloromethylene diphosphonate (DMDP), with an interval of 5 days between the injections, there was complete elimination of Kupffer cells (hepatic macrophages) for a 9-day period starting 1 day after the first injection. The inflammatory and necrotic changes were significantly reduced in mice injected with liposomes containing DMDP as compared to uninjected mice or mice injected with empty liposomes; serum ALT activities were also significantly reduced. No significant difference was seen in serum tumour necrosis factor-alpha levels between the different groups. Kupffer cells therefore play a significant role in the development of the liver damage resulting from exposure to ethanol. Acetaldehyde production by Kupffer cells is one way in which these cells can damage hepatocytes and further work needs to be done to investigate this and other mechanisms.</description><identifier>ISSN: 0959-9673</identifier><identifier>EISSN: 1365-2613</identifier><identifier>PMID: 7488549</identifier><language>eng</language><publisher>Oxford: Blackwell Science</publisher><subject>Animals ; Biological and medical sciences ; Cell Death ; Clodronic Acid - pharmacology ; Drug Carriers ; Ethanol ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Immunoenzyme Techniques ; Kupffer Cells - drug effects ; Kupffer Cells - physiology ; Liposomes ; Liver Diseases, Alcoholic - pathology ; Liver Diseases, Alcoholic - prevention & control ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Other diseases. 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D</creatorcontrib><creatorcontrib>RATNAYAKA, I. D</creatorcontrib><creatorcontrib>BROWN, I. N</creatorcontrib><creatorcontrib>WICKRAMASINGHE, S. N</creatorcontrib><title>The effect of Kupffer cell elimination on ethanol-induced liver damage in mice</title><title>International journal of experimental pathology</title><addtitle>Int J Exp Pathol</addtitle><description>C57BL/10 mice develop inflammatory and necrotic changes in the liver, as well as raised serum ALT activities, after 9 days of exposure to ethanol vapour. If mice were injected twice with liposomes containing dichloromethylene diphosphonate (DMDP), with an interval of 5 days between the injections, there was complete elimination of Kupffer cells (hepatic macrophages) for a 9-day period starting 1 day after the first injection. The inflammatory and necrotic changes were significantly reduced in mice injected with liposomes containing DMDP as compared to uninjected mice or mice injected with empty liposomes; serum ALT activities were also significantly reduced. No significant difference was seen in serum tumour necrosis factor-alpha levels between the different groups. Kupffer cells therefore play a significant role in the development of the liver damage resulting from exposure to ethanol. Acetaldehyde production by Kupffer cells is one way in which these cells can damage hepatocytes and further work needs to be done to investigate this and other mechanisms.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Death</subject><subject>Clodronic Acid - pharmacology</subject><subject>Drug Carriers</subject><subject>Ethanol</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Immunoenzyme Techniques</subject><subject>Kupffer Cells - drug effects</subject><subject>Kupffer Cells - physiology</subject><subject>Liposomes</subject><subject>Liver Diseases, Alcoholic - pathology</subject><subject>Liver Diseases, Alcoholic - prevention & control</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Other diseases. Semiology</subject><issn>0959-9673</issn><issn>1365-2613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRaq3-BGEPXgP7mc1cBCl-YdFLPYfJZrdZ2WxCkhb89wYsRWFgBp53HoY5I0suc52JnMtzsmSgIYPcyEtyNY5fjHEpuFmQhVFFoRUsyfu2cdR57-xEO0_f9v08D9S6GKmLoQ0Jp9AlOpebGkxdzEKq99bVNIbDnKyxxZ2jIdE2WHdNLjzG0d0c-4p8Pj1u1y_Z5uP5df2wyXoBbMqUEoxVWBknVSFrVIKDsZzVnlUCkCkjeQWQK2ZyoZTKNYKuVGG8AcW1kCty_-vt91XrauvSNGAs-yG0OHyXHYbyP0mhKXfdoeQAhoOeBbd_BafN42NmfnfkOFqMfsBkw3iKiQJ4Md_xAybZbIs</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>GOLDIN, R. D</creator><creator>RATNAYAKA, I. D</creator><creator>BROWN, I. N</creator><creator>WICKRAMASINGHE, S. N</creator><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>19951001</creationdate><title>The effect of Kupffer cell elimination on ethanol-induced liver damage in mice</title><author>GOLDIN, R. D ; RATNAYAKA, I. D ; BROWN, I. N ; WICKRAMASINGHE, S. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p290t-44200bab7e3483da42197c10df0b29a04731b9964076244465a95b487f7941523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Death</topic><topic>Clodronic Acid - pharmacology</topic><topic>Drug Carriers</topic><topic>Ethanol</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Immunoenzyme Techniques</topic><topic>Kupffer Cells - drug effects</topic><topic>Kupffer Cells - physiology</topic><topic>Liposomes</topic><topic>Liver Diseases, Alcoholic - pathology</topic><topic>Liver Diseases, Alcoholic - prevention & control</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Other diseases. Semiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOLDIN, R. D</creatorcontrib><creatorcontrib>RATNAYAKA, I. D</creatorcontrib><creatorcontrib>BROWN, I. N</creatorcontrib><creatorcontrib>WICKRAMASINGHE, S. N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOLDIN, R. D</au><au>RATNAYAKA, I. D</au><au>BROWN, I. N</au><au>WICKRAMASINGHE, S. N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of Kupffer cell elimination on ethanol-induced liver damage in mice</atitle><jtitle>International journal of experimental pathology</jtitle><addtitle>Int J Exp Pathol</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>76</volume><issue>5</issue><spage>353</spage><epage>359</epage><pages>353-359</pages><issn>0959-9673</issn><eissn>1365-2613</eissn><abstract>C57BL/10 mice develop inflammatory and necrotic changes in the liver, as well as raised serum ALT activities, after 9 days of exposure to ethanol vapour. If mice were injected twice with liposomes containing dichloromethylene diphosphonate (DMDP), with an interval of 5 days between the injections, there was complete elimination of Kupffer cells (hepatic macrophages) for a 9-day period starting 1 day after the first injection. The inflammatory and necrotic changes were significantly reduced in mice injected with liposomes containing DMDP as compared to uninjected mice or mice injected with empty liposomes; serum ALT activities were also significantly reduced. No significant difference was seen in serum tumour necrosis factor-alpha levels between the different groups. Kupffer cells therefore play a significant role in the development of the liver damage resulting from exposure to ethanol. Acetaldehyde production by Kupffer cells is one way in which these cells can damage hepatocytes and further work needs to be done to investigate this and other mechanisms.</abstract><cop>Oxford</cop><pub>Blackwell Science</pub><pmid>7488549</pmid><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0959-9673 |
| ispartof | International journal of experimental pathology, 1995-10, Vol.76 (5), p.353-359 |
| issn | 0959-9673 1365-2613 |
| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Animals Biological and medical sciences Cell Death Clodronic Acid - pharmacology Drug Carriers Ethanol Female Gastroenterology. Liver. Pancreas. Abdomen Immunoenzyme Techniques Kupffer Cells - drug effects Kupffer Cells - physiology Liposomes Liver Diseases, Alcoholic - pathology Liver Diseases, Alcoholic - prevention & control Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Inbred C57BL Other diseases. Semiology |
| title | The effect of Kupffer cell elimination on ethanol-induced liver damage in mice |
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