Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats
We report mycobacterial granulomatous inflammation in the ulcerated caecum of rats that received indomethacin. Two groups of male rats were treated with dietary indomethacin 3 mg/kg/day or untreated diet for 3 weeks. Six out of 8 indomethacin treated rats showed both ulceration and inflammation of t...
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| Veröffentlicht in: | International journal of experimental pathology 1995-04, Vol.76 (2), p.149-155 |
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| container_title | International journal of experimental pathology |
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| creator | ANTHONY, A DHILLON, A. P FIDLER, H MCFADDEN, J BILLINGTON, O NYGARD, G POUNDER, R. E WAKEFIELD, A. J |
| description | We report mycobacterial granulomatous inflammation in the ulcerated caecum of rats that received indomethacin. Two groups of male rats were treated with dietary indomethacin 3 mg/kg/day or untreated diet for 3 weeks. Six out of 8 indomethacin treated rats showed both ulceration and inflammation of the caecal mucosa. Two of the rats showing caecal ulceration also showed distinct granulomatous inflammation of the caecal mucosa and acid-fast bacilli were identified within granulomata. None of the other indomethacin treated or control rats contained acid-fast bacilli within caecal tissue sections but they were present, in the same sections, within the lumen of most rats in both groups. Polymerase chain reaction analysis identified the mycobacterial 65 kDa GroEL gene within control and granulomatous caecal tissue. In a repeat of indomethacin administration to a third group of rats, culture of both non-granulomatous caecal tissue (containing histologically identified luminal acid-fast bacilli) and faecal samples for mycobacteria was negative. |
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P ; FIDLER, H ; MCFADDEN, J ; BILLINGTON, O ; NYGARD, G ; POUNDER, R. E ; WAKEFIELD, A. J</creator><creatorcontrib>ANTHONY, A ; DHILLON, A. P ; FIDLER, H ; MCFADDEN, J ; BILLINGTON, O ; NYGARD, G ; POUNDER, R. E ; WAKEFIELD, A. J</creatorcontrib><description>We report mycobacterial granulomatous inflammation in the ulcerated caecum of rats that received indomethacin. Two groups of male rats were treated with dietary indomethacin 3 mg/kg/day or untreated diet for 3 weeks. Six out of 8 indomethacin treated rats showed both ulceration and inflammation of the caecal mucosa. Two of the rats showing caecal ulceration also showed distinct granulomatous inflammation of the caecal mucosa and acid-fast bacilli were identified within granulomata. None of the other indomethacin treated or control rats contained acid-fast bacilli within caecal tissue sections but they were present, in the same sections, within the lumen of most rats in both groups. Polymerase chain reaction analysis identified the mycobacterial 65 kDa GroEL gene within control and granulomatous caecal tissue. In a repeat of indomethacin administration to a third group of rats, culture of both non-granulomatous caecal tissue (containing histologically identified luminal acid-fast bacilli) and faecal samples for mycobacteria was negative.</description><identifier>ISSN: 0959-9673</identifier><identifier>EISSN: 1365-2613</identifier><identifier>PMID: 7786765</identifier><language>eng</language><publisher>Oxford: Blackwell Science</publisher><subject>Animals ; Bacterial diseases ; Biological and medical sciences ; Cecal Diseases - chemically induced ; Cecal Diseases - complications ; Cecal Diseases - pathology ; Cecum - pathology ; Experimental bacterial diseases and models ; Granuloma - complications ; Granuloma - pathology ; Indomethacin - toxicity ; Infectious diseases ; Male ; Medical sciences ; Mycobacterium Infections - complications ; Mycobacterium Infections - pathology ; Opportunistic Infections - complications ; Opportunistic Infections - pathology ; Polymerase Chain Reaction ; Rats ; Rats, Sprague-Dawley ; Ulcer - chemically induced ; Ulcer - complications ; Ulcer - pathology</subject><ispartof>International journal of experimental pathology, 1995-04, Vol.76 (2), p.149-155</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1997147/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1997147/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,309,310,314,723,776,780,785,786,881,23909,23910,25118,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3488496$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7786765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANTHONY, A</creatorcontrib><creatorcontrib>DHILLON, A. P</creatorcontrib><creatorcontrib>FIDLER, H</creatorcontrib><creatorcontrib>MCFADDEN, J</creatorcontrib><creatorcontrib>BILLINGTON, O</creatorcontrib><creatorcontrib>NYGARD, G</creatorcontrib><creatorcontrib>POUNDER, R. E</creatorcontrib><creatorcontrib>WAKEFIELD, A. J</creatorcontrib><title>Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats</title><title>International journal of experimental pathology</title><addtitle>Int J Exp Pathol</addtitle><description>We report mycobacterial granulomatous inflammation in the ulcerated caecum of rats that received indomethacin. Two groups of male rats were treated with dietary indomethacin 3 mg/kg/day or untreated diet for 3 weeks. Six out of 8 indomethacin treated rats showed both ulceration and inflammation of the caecal mucosa. Two of the rats showing caecal ulceration also showed distinct granulomatous inflammation of the caecal mucosa and acid-fast bacilli were identified within granulomata. None of the other indomethacin treated or control rats contained acid-fast bacilli within caecal tissue sections but they were present, in the same sections, within the lumen of most rats in both groups. Polymerase chain reaction analysis identified the mycobacterial 65 kDa GroEL gene within control and granulomatous caecal tissue. In a repeat of indomethacin administration to a third group of rats, culture of both non-granulomatous caecal tissue (containing histologically identified luminal acid-fast bacilli) and faecal samples for mycobacteria was negative.</description><subject>Animals</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cecal Diseases - chemically induced</subject><subject>Cecal Diseases - complications</subject><subject>Cecal Diseases - pathology</subject><subject>Cecum - pathology</subject><subject>Experimental bacterial diseases and models</subject><subject>Granuloma - complications</subject><subject>Granuloma - pathology</subject><subject>Indomethacin - toxicity</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium Infections - complications</subject><subject>Mycobacterium Infections - pathology</subject><subject>Opportunistic Infections - complications</subject><subject>Opportunistic Infections - pathology</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Ulcer - chemically induced</subject><subject>Ulcer - complications</subject><subject>Ulcer - pathology</subject><issn>0959-9673</issn><issn>1365-2613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLxDAUhYMo4zj6E4Qu3Baad7IRZPAFI250KeU2TaaRthnSVJh_b9Bh0NXl8J37Lc4JWmIqeEkEpqdoWWmuSy0kPUcX0_RZVZgSLBdoIaUSUvAl-njZm9CASTZ66ItthHHuwwApzFPhR9fDkIMPYw5F6mwx98ZGSLYtDFgzD0VwGbVhsKkD48cyRfuDc2m6RGcO-sleHe4KvT_cv62fys3r4_P6blPuSMVTyRhvCSaMqAZrRxrXYq2o5Y3hjZXEaQoOC85cVVGtTKuN5FzTRlAGCqiiK3T7693NzWBbY8cUoa930Q8Q93UAX_8no-_qbfiqsdYSM5kF138Fx8_DTpnfHDhMBnqXZzJ-OtYoU4ppQb8BbSZ1Ag</recordid><startdate>19950401</startdate><enddate>19950401</enddate><creator>ANTHONY, A</creator><creator>DHILLON, A. P</creator><creator>FIDLER, H</creator><creator>MCFADDEN, J</creator><creator>BILLINGTON, O</creator><creator>NYGARD, G</creator><creator>POUNDER, R. E</creator><creator>WAKEFIELD, A. J</creator><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>19950401</creationdate><title>Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats</title><author>ANTHONY, A ; DHILLON, A. P ; FIDLER, H ; MCFADDEN, J ; BILLINGTON, O ; NYGARD, G ; POUNDER, R. E ; WAKEFIELD, A. 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P</creatorcontrib><creatorcontrib>FIDLER, H</creatorcontrib><creatorcontrib>MCFADDEN, J</creatorcontrib><creatorcontrib>BILLINGTON, O</creatorcontrib><creatorcontrib>NYGARD, G</creatorcontrib><creatorcontrib>POUNDER, R. E</creatorcontrib><creatorcontrib>WAKEFIELD, A. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ANTHONY, A</au><au>DHILLON, A. P</au><au>FIDLER, H</au><au>MCFADDEN, J</au><au>BILLINGTON, O</au><au>NYGARD, G</au><au>POUNDER, R. E</au><au>WAKEFIELD, A. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats</atitle><jtitle>International journal of experimental pathology</jtitle><addtitle>Int J Exp Pathol</addtitle><date>1995-04-01</date><risdate>1995</risdate><volume>76</volume><issue>2</issue><spage>149</spage><epage>155</epage><pages>149-155</pages><issn>0959-9673</issn><eissn>1365-2613</eissn><abstract>We report mycobacterial granulomatous inflammation in the ulcerated caecum of rats that received indomethacin. Two groups of male rats were treated with dietary indomethacin 3 mg/kg/day or untreated diet for 3 weeks. Six out of 8 indomethacin treated rats showed both ulceration and inflammation of the caecal mucosa. Two of the rats showing caecal ulceration also showed distinct granulomatous inflammation of the caecal mucosa and acid-fast bacilli were identified within granulomata. None of the other indomethacin treated or control rats contained acid-fast bacilli within caecal tissue sections but they were present, in the same sections, within the lumen of most rats in both groups. Polymerase chain reaction analysis identified the mycobacterial 65 kDa GroEL gene within control and granulomatous caecal tissue. In a repeat of indomethacin administration to a third group of rats, culture of both non-granulomatous caecal tissue (containing histologically identified luminal acid-fast bacilli) and faecal samples for mycobacteria was negative.</abstract><cop>Oxford</cop><pub>Blackwell Science</pub><pmid>7786765</pmid><tpages>7</tpages></addata></record> |
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| ispartof | International journal of experimental pathology, 1995-04, Vol.76 (2), p.149-155 |
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| subjects | Animals Bacterial diseases Biological and medical sciences Cecal Diseases - chemically induced Cecal Diseases - complications Cecal Diseases - pathology Cecum - pathology Experimental bacterial diseases and models Granuloma - complications Granuloma - pathology Indomethacin - toxicity Infectious diseases Male Medical sciences Mycobacterium Infections - complications Mycobacterium Infections - pathology Opportunistic Infections - complications Opportunistic Infections - pathology Polymerase Chain Reaction Rats Rats, Sprague-Dawley Ulcer - chemically induced Ulcer - complications Ulcer - pathology |
| title | Mycobacterial granulomatous inflammation in the ulcerated caecum of indomethacin-treated rats |
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