Physicochemical properties affecting lipofection potency of a new series of 1,2-dialkoylamidopropane-based cationic lipids

The in vitro transfection activity of a novel series of N, N′-diacyl-1,2-diaminopropyl-3-carbamoyl-(aminoethane) derivatives was evaluated against a mouse melanoma cell line at different ± charge ratios, in the presence and absence of helper lipids. Only the unsaturated derivative N, N′-dioleoyl-1,2...

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