Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat

Previous studies have failed to reveal an effect of the gastrointestinal peptide hormone ghrelin on colonic motility. In the present work, ghrelin was applied into the lumbo-sacral spinal cord in the region of defecation control centres, and a synthetic ghrelin receptor agonist, CP464709, which cros...

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Veröffentlicht in:	The Journal of physiology 2006-10, Vol.576 (1), p.329-338
Hauptverfasser:	Shimizu, Yasutake, Chang, Ed C., Shafton, Anthony D., Ferens, Dorota M., Sanger, Gareth J., Witherington, Jason, Furness, John B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alimentary Animals Colon - innervation Colon - physiology Defecation - drug effects Defecation - physiology Evoked Potentials - drug effects Evoked Potentials - physiology Ganglionic Blockers - pharmacology Gastrointestinal Motility - drug effects Gastrointestinal Motility - physiology Ghrelin Hexamethonium - pharmacology Male Motor Neurons - drug effects Motor Neurons - physiology Peptide Hormones - physiology Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - physiology Receptors, Ghrelin Spinal Cord - physiology
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