Computational biology in the study of cardiac ion channels and cell electrophysiology

1. Prologue 58 2. The Hodgkin–Huxley formalism for computing the action potential 59 2.1 The axon action potential model 59 2.2 Cardiac action potential models 62 3. Ion-channel based formulation of the action potential 65 3.1 Ion-channel structure 65 3.2 Markov models of ion-channel kinetics 66 3.3...

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Veröffentlicht in:	Quarterly reviews of biophysics 2006-02, Vol.39 (1), p.57-116
Hauptverfasser:	Rudy, Yoram, Silva, Jonathan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Biophysical Phenomena Biophysics Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cellular biology Computational Biology Computer Simulation Electrophysiology ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - genetics Ether-A-Go-Go Potassium Channels - metabolism Heart Humans Ion Channels - genetics Ion Channels - metabolism Ions Kinetics Markov Chains Models, Cardiovascular Muscle Proteins - genetics Muscle Proteins - metabolism Mutation Myocytes, Cardiac - metabolism NAV1.5 Voltage-Gated Sodium Channel Receptors, Adrenergic, beta - metabolism Signal Transduction Sodium Channels - genetics Sodium Channels - metabolism
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