Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status
Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear. Aim: To compare cardia versus non-cardia cancer with respect to the premorbid state of...
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| Veröffentlicht in: | Gut 2007-07, Vol.56 (7), p.918-925 |
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| creator | Hansen, Svein Vollset, Stein Emil Derakhshan, Mohammad H Fyfe, Valerie Melby, Kjetil K Aase, Steinar Jellum, Egil McColl, Kenneth E L |
| description | Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear. Aim: To compare cardia versus non-cardia cancer with respect to the premorbid state of the stomach. Methods: Nested case–control study. To each of 129 non-cardia and 44 cardia cancers, three controls were matched. Serum collected a median of 11.9 years before the diagnosis of cancer was tested for anti-H pylori antibodies, pepsinogen I:II and gastrin. Results: Non-cardia cancer was positively associated with H pylori (OR 4.75, 95% CI 2.56 to 8.81) and gastric atrophy (pepsinogen I:II |
| doi_str_mv | 10.1136/gut.2006.114504 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1994366</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4014205451</sourcerecordid><originalsourceid>FETCH-LOGICAL-b619t-cd2211412ea2a0e940b9ce0bd4a81cf15f40dac25087c40d956995d9750394533</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhzA1ZQvSAlNYf8ZeQkOgKukgruJReLcdxtl6SONhOYf8BPxt3s2qBA5w81jwznvH7FsVzBE8RIuxsM6VTDCHLt4rC6kGxQBUTJcFCPCwWECJeUl7Jo-JJjFsIoRASPS6OECeIcyEWxc_L7x40LiY3mAS0Tc53fuNsBL4FRofG6XwMxoY3wN64xuYQtMH3YAy296F2DYg27IuM7kCvw1cb9tUbHVNwBugU_Hi9A3powMp2zvham2QDGHedDw7EpNMUnxaPWt1F--xwHhdfPry_XK7K9eeLj8t367JmSKbSNBjnXRG2GmtoZQVraSysm0oLZFpE2wo22mAKBTc5lJRJSRvJKSSyooQcF2_nvuNU97YxdkhBd2oMLo--U1479WdmcNdq428UkrIijOUGJ4cGwX-bbEyqd9HYrtOD9VNUHDKM2f6lf4MYMkQgqzL48i9w66cw5F9QWSVJiKAYZ-pspkzwMQbb3s2MoLo1g8pmULdmULMZcsWL31e95w_qZ-DVAdAxi9eGLLSL95wQSCBEM1fOXPaJ_XGXz1Irxgmn6tPVUl2tL1ZsKc8Vz_zrma_77X-n_AXCL9vU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779338522</pqid></control><display><type>article</type><title>Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Hansen, Svein ; Vollset, Stein Emil ; Derakhshan, Mohammad H ; Fyfe, Valerie ; Melby, Kjetil K ; Aase, Steinar ; Jellum, Egil ; McColl, Kenneth E L</creator><creatorcontrib>Hansen, Svein ; Vollset, Stein Emil ; Derakhshan, Mohammad H ; Fyfe, Valerie ; Melby, Kjetil K ; Aase, Steinar ; Jellum, Egil ; McColl, Kenneth E L</creatorcontrib><description>Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear. Aim: To compare cardia versus non-cardia cancer with respect to the premorbid state of the stomach. Methods: Nested case–control study. To each of 129 non-cardia and 44 cardia cancers, three controls were matched. Serum collected a median of 11.9 years before the diagnosis of cancer was tested for anti-H pylori antibodies, pepsinogen I:II and gastrin. Results: Non-cardia cancer was positively associated with H pylori (OR 4.75, 95% CI 2.56 to 8.81) and gastric atrophy (pepsinogen I:II <2.5; OR 4.47, 95% CI 2.71 to 7.37). The diffuse and intestinal histological subtypes of non-cardia cancer were of similar proportions and both showed a positive association with H pylori and atrophy. Cardia cancer was negatively associated with H pylori (OR 0.27, 95% CI 0.12 to 0.59), but H pylori-positive cardia cancer showed an association with gastric atrophy (OR 3.33, 95% CI 1.06 to 10.5). The predominant histological subtype of cardia cancer was intestinal and was not associated with gastric atrophy compared with the diffuse subtype ((OR 0.72, 95% CI 0.19 to 2.79) vs (OR 3.46, 95% CI 0.32 to 37.5)). Cardia cancer in patients with atrophy had an intestinal: diffuse ratio (1:1) similar to non-cardia cancer (1.9:1), whereas cardia cancers in patients without atrophy were predominantly intestinal (7:1). Conclusion: These findings indicate two aetiologies of cardia cancer, one associated with H pylori atrophic gastritis, resembling non-cardia cancer, and the other associated with non-atrophic gastric mucosa, resembling oesophageal adenocarcinoma. Serological markers of gastric atrophy may provide the key to determining gastric versus oesophageal origin of cardia cancer.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gut.2006.114504</identifier><identifier>PMID: 17317788</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Adenocarcinoma - etiology ; Adenocarcinoma - microbiology ; Adenocarcinoma - pathology ; Adult ; Atrophy ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Biomarkers - blood ; Biopsy ; Cardia ; Cardiovascular disease ; Case-Control Studies ; Endoscopy ; Female ; Gastric Cancer ; Gastrins - blood ; Gastritis, Atrophic - complications ; Gastritis, Atrophic - diagnosis ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - complications ; Helicobacter Infections - diagnosis ; Helicobacter pylori ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Male ; Medical sciences ; Medical screening ; Middle Aged ; Other diseases. Semiology ; Pepsinogen A - blood ; Pepsinogen C - blood ; pepsinogen I to pepsinogen II ratio ; PGI:II ; Precancerous Conditions - blood ; Regression analysis ; Risk Factors ; Stomach Neoplasms - etiology ; Stomach Neoplasms - microbiology ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Gut, 2007-07, Vol.56 (7), p.918-925</ispartof><rights>Copyright 2007 by Gut</rights><rights>2007 INIST-CNRS</rights><rights>Copyright: 2007 Copyright 2007 by Gut</rights><rights>Copyright © 2007 BMJ Publishing Group & British Society of Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b619t-cd2211412ea2a0e940b9ce0bd4a81cf15f40dac25087c40d956995d9750394533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://gut.bmj.com/content/56/7/918.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://gut.bmj.com/content/56/7/918.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,315,728,781,785,886,3197,23576,27929,27930,53796,53798,77605,77636</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18818115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17317788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, Svein</creatorcontrib><creatorcontrib>Vollset, Stein Emil</creatorcontrib><creatorcontrib>Derakhshan, Mohammad H</creatorcontrib><creatorcontrib>Fyfe, Valerie</creatorcontrib><creatorcontrib>Melby, Kjetil K</creatorcontrib><creatorcontrib>Aase, Steinar</creatorcontrib><creatorcontrib>Jellum, Egil</creatorcontrib><creatorcontrib>McColl, Kenneth E L</creatorcontrib><title>Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status</title><title>Gut</title><addtitle>Gut</addtitle><description>Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear. Aim: To compare cardia versus non-cardia cancer with respect to the premorbid state of the stomach. Methods: Nested case–control study. To each of 129 non-cardia and 44 cardia cancers, three controls were matched. Serum collected a median of 11.9 years before the diagnosis of cancer was tested for anti-H pylori antibodies, pepsinogen I:II and gastrin. Results: Non-cardia cancer was positively associated with H pylori (OR 4.75, 95% CI 2.56 to 8.81) and gastric atrophy (pepsinogen I:II <2.5; OR 4.47, 95% CI 2.71 to 7.37). The diffuse and intestinal histological subtypes of non-cardia cancer were of similar proportions and both showed a positive association with H pylori and atrophy. Cardia cancer was negatively associated with H pylori (OR 0.27, 95% CI 0.12 to 0.59), but H pylori-positive cardia cancer showed an association with gastric atrophy (OR 3.33, 95% CI 1.06 to 10.5). The predominant histological subtype of cardia cancer was intestinal and was not associated with gastric atrophy compared with the diffuse subtype ((OR 0.72, 95% CI 0.19 to 2.79) vs (OR 3.46, 95% CI 0.32 to 37.5)). Cardia cancer in patients with atrophy had an intestinal: diffuse ratio (1:1) similar to non-cardia cancer (1.9:1), whereas cardia cancers in patients without atrophy were predominantly intestinal (7:1). Conclusion: These findings indicate two aetiologies of cardia cancer, one associated with H pylori atrophic gastritis, resembling non-cardia cancer, and the other associated with non-atrophic gastric mucosa, resembling oesophageal adenocarcinoma. Serological markers of gastric atrophy may provide the key to determining gastric versus oesophageal origin of cardia cancer.</description><subject>Adenocarcinoma - etiology</subject><subject>Adenocarcinoma - microbiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Atrophy</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biopsy</subject><subject>Cardia</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Gastric Cancer</subject><subject>Gastrins - blood</subject><subject>Gastritis, Atrophic - complications</subject><subject>Gastritis, Atrophic - diagnosis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter pylori</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pepsinogen A - blood</subject><subject>Pepsinogen C - blood</subject><subject>pepsinogen I to pepsinogen II ratio</subject><subject>PGI:II</subject><subject>Precancerous Conditions - blood</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter pylori</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pepsinogen A - blood</topic><topic>Pepsinogen C - blood</topic><topic>pepsinogen I to pepsinogen II ratio</topic><topic>PGI:II</topic><topic>Precancerous Conditions - blood</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - etiology</topic><topic>Stomach Neoplasms - microbiology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hansen, Svein</creatorcontrib><creatorcontrib>Vollset, Stein Emil</creatorcontrib><creatorcontrib>Derakhshan, Mohammad H</creatorcontrib><creatorcontrib>Fyfe, Valerie</creatorcontrib><creatorcontrib>Melby, Kjetil K</creatorcontrib><creatorcontrib>Aase, Steinar</creatorcontrib><creatorcontrib>Jellum, Egil</creatorcontrib><creatorcontrib>McColl, Kenneth E L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hansen, Svein</au><au>Vollset, Stein Emil</au><au>Derakhshan, Mohammad H</au><au>Fyfe, Valerie</au><au>Melby, Kjetil K</au><au>Aase, Steinar</au><au>Jellum, Egil</au><au>McColl, Kenneth E L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>56</volume><issue>7</issue><spage>918</spage><epage>925</epage><pages>918-925</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><coden>GUTTAK</coden><abstract>Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear. Aim: To compare cardia versus non-cardia cancer with respect to the premorbid state of the stomach. Methods: Nested case–control study. To each of 129 non-cardia and 44 cardia cancers, three controls were matched. Serum collected a median of 11.9 years before the diagnosis of cancer was tested for anti-H pylori antibodies, pepsinogen I:II and gastrin. Results: Non-cardia cancer was positively associated with H pylori (OR 4.75, 95% CI 2.56 to 8.81) and gastric atrophy (pepsinogen I:II <2.5; OR 4.47, 95% CI 2.71 to 7.37). The diffuse and intestinal histological subtypes of non-cardia cancer were of similar proportions and both showed a positive association with H pylori and atrophy. Cardia cancer was negatively associated with H pylori (OR 0.27, 95% CI 0.12 to 0.59), but H pylori-positive cardia cancer showed an association with gastric atrophy (OR 3.33, 95% CI 1.06 to 10.5). The predominant histological subtype of cardia cancer was intestinal and was not associated with gastric atrophy compared with the diffuse subtype ((OR 0.72, 95% CI 0.19 to 2.79) vs (OR 3.46, 95% CI 0.32 to 37.5)). Cardia cancer in patients with atrophy had an intestinal: diffuse ratio (1:1) similar to non-cardia cancer (1.9:1), whereas cardia cancers in patients without atrophy were predominantly intestinal (7:1). Conclusion: These findings indicate two aetiologies of cardia cancer, one associated with H pylori atrophic gastritis, resembling non-cardia cancer, and the other associated with non-atrophic gastric mucosa, resembling oesophageal adenocarcinoma. Serological markers of gastric atrophy may provide the key to determining gastric versus oesophageal origin of cardia cancer.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>17317788</pmid><doi>10.1136/gut.2006.114504</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - etiology Adenocarcinoma - microbiology Adenocarcinoma - pathology Adult Atrophy Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biomarkers - blood Biopsy Cardia Cardiovascular disease Case-Control Studies Endoscopy Female Gastric Cancer Gastrins - blood Gastritis, Atrophic - complications Gastritis, Atrophic - diagnosis Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - complications Helicobacter Infections - diagnosis Helicobacter pylori Human bacterial diseases Humans Infections Infectious diseases Male Medical sciences Medical screening Middle Aged Other diseases. Semiology Pepsinogen A - blood Pepsinogen C - blood pepsinogen I to pepsinogen II ratio PGI:II Precancerous Conditions - blood Regression analysis Risk Factors Stomach Neoplasms - etiology Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status |
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