Increased atherosclerosis in myeloperoxidase-deficient mice

Myeloperoxidase (MPO), a heme enzyme secreted by activated phagocytes, generates an array of oxidants proposed to play critical roles in host defense and local tissue damage. Both MPO and its reaction products are present in human atherosclerotic plaque, and it has been proposed that MPO oxidatively...

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Veröffentlicht in:	The Journal of clinical investigation 2001-02, Vol.107 (4), p.419-430
Hauptverfasser:	Brennan, M L, Anderson, M M, Shih, D M, Qu, X D, Wang, X, Mehta, A C, Lim, L L, Shi, W, Hazen, S L, Jacob, J S, Crowley, J R, Heinecke, J W, Lusis, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis - etiology Candida albicans - immunology Humans Hypochlorous Acid - metabolism Mice Mice, Inbred C57BL Myeloperoxidase Neutrophils - enzymology Oxidation-Reduction Peroxidase - deficiency Peroxidase - genetics Peroxidase - physiology Phagocytes - metabolism Tyrosine - analogs & derivatives Tyrosine - analysis
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