Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals

O 6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that protects cells from the biological consequences of alkylating agents by removing alkyl groups from the O 6-position of guanine. Cyclophosphamide and ifosfamide are oxazaphosphorines used clinically to treat a wide variety of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	DNA repair 2007-08, Vol.6 (8), p.1145-1154
Hauptverfasser:	Hansen, Ryan J., Ludeman, Susan M., Paikoff, Sari J., Pegg, Anthony E., Dolan, M. Eileen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - analogs & derivatives Acetaldehyde - toxicity Acrolein Acrolein - toxicity Alkylating Agents - metabolism Alkylating Agents - toxicity Alkyltransferase Animals Chloroacetaldehyde CHO Cells Cricetinae Cricetulus Cyclophosphamide - metabolism Cyclophosphamide - toxicity DNA Repair Drug Resistance, Neoplasm Ifosfamide Ifosfamide - metabolism Ifosfamide - toxicity Mice Mice, Knockout Mutation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - enzymology O-Methylguanine-DNA Methyltransferase - deficiency O-Methylguanine-DNA Methyltransferase - genetics O-Methylguanine-DNA Methyltransferase - metabolism Oxazaphosphorines Recombinant Proteins - genetics Recombinant Proteins - metabolism Transfection Transplantation, Heterologous
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!