Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo

Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial αvβ3 integrin. To determine the contribution of L...

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Veröffentlicht in:	Blood 2007-10, Vol.110 (7), p.2708-2717
Hauptverfasser:	Zennadi, Rahima, Moeller, Benjamin J., Whalen, Erin J., Batchvarova, Milena, Xu, Ke, Shan, Siqing, Delahunty, Martha, Dewhirst, Mark W., Telen, Marilyn J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - metabolism Anemia, Sickle Cell - pathology Animals Biological and medical sciences Cell Adhesion - drug effects Cell Adhesion Molecules - metabolism Cell Survival Cells, Cultured Endothelium - blood supply Endothelium - drug effects Endothelium - pathology Epinephrine - pharmacology Erythrocytes - cytology Erythrocytes - drug effects Hematologic and hematopoietic diseases Humans Leukocytes - cytology Leukocytes - drug effects Leukocytes - immunology Medical sciences Mice Mice, Nude Receptors, Adrenergic, beta-2 - metabolism Red Cells
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