Interference of sodium with [3H]‐nitrendipine binding to cardiac membranes
1 Interference of sodium with [3H]‐nitrendipine binding was studied on membrane homogenates from guinea‐pig skeletal muscle, cerebral cortex and left cardiac ventricle. 2 [3H]‐nitrendipine binding on homogenates from cerebral cortex and skeletal muscle was unaffected by Na+ (35 and 140 mEql−1). 3 On...
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| Veröffentlicht in: | British journal of pharmacology 1985-02, Vol.84 (2), p.511-515 |
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| container_title | British journal of pharmacology |
| container_volume | 84 |
| creator | Schwartz, Jean Velly, Jeanne |
| description | 1
Interference of sodium with [3H]‐nitrendipine binding was studied on membrane homogenates from guinea‐pig skeletal muscle, cerebral cortex and left cardiac ventricle.
2
[3H]‐nitrendipine binding on homogenates from cerebral cortex and skeletal muscle was unaffected by Na+ (35 and 140 mEql−1).
3
On the other hand, for the myocardial receptors, addition of Na+ resulted in an increase in IC50 of nitrendipine.
4
Simultaneously, for the myocardial preparations, saturation curves showed a decrease in [3H]‐nitrendipine affinity and an increase in the number of binding sites. |
| doi_str_mv | 10.1111/j.1476-5381.1985.tb12935.x |
| format | Article |
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Interference of sodium with [3H]‐nitrendipine binding was studied on membrane homogenates from guinea‐pig skeletal muscle, cerebral cortex and left cardiac ventricle.
2
[3H]‐nitrendipine binding on homogenates from cerebral cortex and skeletal muscle was unaffected by Na+ (35 and 140 mEql−1).
3
On the other hand, for the myocardial receptors, addition of Na+ resulted in an increase in IC50 of nitrendipine.
4
Simultaneously, for the myocardial preparations, saturation curves showed a decrease in [3H]‐nitrendipine affinity and an increase in the number of binding sites.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1985.tb12935.x</identifier><identifier>PMID: 3156649</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Binding, Competitive - drug effects ; Biological and medical sciences ; Calcium Channel Blockers - metabolism ; Cardiovascular system ; Cerebral Cortex - metabolism ; Guinea Pigs ; Heart - drug effects ; In Vitro Techniques ; Kinetics ; Medical sciences ; Membranes - metabolism ; Miscellaneous ; Muscles - metabolism ; Myocardium - metabolism ; Nifedipine - analogs & derivatives ; Nifedipine - metabolism ; Nitrendipine ; Pharmacology. Drug treatments ; Sodium - pharmacology</subject><ispartof>British journal of pharmacology, 1985-02, Vol.84 (2), p.511-515</ispartof><rights>1985 British Pharmacological Society</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5075-f7d6f5c1b4377f27d979d622633a1d3c11fd4cfc2d69a90c5854ffd620c4f0ec3</citedby><cites>FETCH-LOGICAL-c5075-f7d6f5c1b4377f27d979d622633a1d3c11fd4cfc2d69a90c5854ffd620c4f0ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1987275/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1987275/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9291945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3156649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwartz, Jean</creatorcontrib><creatorcontrib>Velly, Jeanne</creatorcontrib><title>Interference of sodium with [3H]‐nitrendipine binding to cardiac membranes</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Interference of sodium with [3H]‐nitrendipine binding was studied on membrane homogenates from guinea‐pig skeletal muscle, cerebral cortex and left cardiac ventricle.
2
[3H]‐nitrendipine binding on homogenates from cerebral cortex and skeletal muscle was unaffected by Na+ (35 and 140 mEql−1).
3
On the other hand, for the myocardial receptors, addition of Na+ resulted in an increase in IC50 of nitrendipine.
4
Simultaneously, for the myocardial preparations, saturation curves showed a decrease in [3H]‐nitrendipine affinity and an increase in the number of binding sites.</description><subject>Animals</subject><subject>Binding, Competitive - drug effects</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - metabolism</subject><subject>Cardiovascular system</subject><subject>Cerebral Cortex - metabolism</subject><subject>Guinea Pigs</subject><subject>Heart - drug effects</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Membranes - metabolism</subject><subject>Miscellaneous</subject><subject>Muscles - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Nifedipine - analogs & derivatives</subject><subject>Nifedipine - metabolism</subject><subject>Nitrendipine</subject><subject>Pharmacology. Drug treatments</subject><subject>Sodium - pharmacology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1O3DAUha2qaBigj1ApQhW7BDuO47iLqnRUmJFGggWsUGU5_gGP8jO1k86w4xH6jDwJDhON6LLe-ErfucfX5wJwimCCwjlfJSijeUxwgRLECpJ0JUoZJsn2A5ju0UcwhRDSGKGiOARH3q8gDJCSCZhgRPI8Y1OwXDSddkY73UgdtSbyrbJ9HW1s9xjd4_mvl-e_je0CVnZtGx2VNlTNQ9S1kRROWSGjWtelE432J-DAiMrrT-N9DO4uf97O5vHy-moxu1jGkkBKYkNVbohEZYYpNSlVjDKVp2mOsUAKS4SMyqSRqcqZYFCSgmTGBAWUmYFa4mPwbee77staK6mbzomKr52thXvirbD8X9LYR_7Q_uEhLJpSEgzORgPX_u6173htvdRVFX7R9p7THGJIMhaEX3dC6VrvnTb7RxDkwy74ig-B8yHwwZ7wcRd8G5o_vx9z3zqGH_iXkQsvRWVChtL6vYylDLFsGPb7TraxlX76jwH4j5v5W4lfAUKVqYk</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Schwartz, Jean</creator><creator>Velly, Jeanne</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198502</creationdate><title>Interference of sodium with [3H]‐nitrendipine binding to cardiac membranes</title><author>Schwartz, Jean ; Velly, Jeanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5075-f7d6f5c1b4377f27d979d622633a1d3c11fd4cfc2d69a90c5854ffd620c4f0ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Binding, Competitive - drug effects</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - metabolism</topic><topic>Cardiovascular system</topic><topic>Cerebral Cortex - metabolism</topic><topic>Guinea Pigs</topic><topic>Heart - drug effects</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Membranes - metabolism</topic><topic>Miscellaneous</topic><topic>Muscles - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Nifedipine - analogs & derivatives</topic><topic>Nifedipine - metabolism</topic><topic>Nitrendipine</topic><topic>Pharmacology. Drug treatments</topic><topic>Sodium - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwartz, Jean</creatorcontrib><creatorcontrib>Velly, Jeanne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwartz, Jean</au><au>Velly, Jeanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interference of sodium with [3H]‐nitrendipine binding to cardiac membranes</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1985-02</date><risdate>1985</risdate><volume>84</volume><issue>2</issue><spage>511</spage><epage>515</epage><pages>511-515</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
Interference of sodium with [3H]‐nitrendipine binding was studied on membrane homogenates from guinea‐pig skeletal muscle, cerebral cortex and left cardiac ventricle.
2
[3H]‐nitrendipine binding on homogenates from cerebral cortex and skeletal muscle was unaffected by Na+ (35 and 140 mEql−1).
3
On the other hand, for the myocardial receptors, addition of Na+ resulted in an increase in IC50 of nitrendipine.
4
Simultaneously, for the myocardial preparations, saturation curves showed a decrease in [3H]‐nitrendipine affinity and an increase in the number of binding sites.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3156649</pmid><doi>10.1111/j.1476-5381.1985.tb12935.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0007-1188 1476-5381 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Binding, Competitive - drug effects Biological and medical sciences Calcium Channel Blockers - metabolism Cardiovascular system Cerebral Cortex - metabolism Guinea Pigs Heart - drug effects In Vitro Techniques Kinetics Medical sciences Membranes - metabolism Miscellaneous Muscles - metabolism Myocardium - metabolism Nifedipine - analogs & derivatives Nifedipine - metabolism Nitrendipine Pharmacology. Drug treatments Sodium - pharmacology |
| title | Interference of sodium with [3H]‐nitrendipine binding to cardiac membranes |
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