Pathophysiological mechanisms of sudden death induced by platelet activating factor

1 Platelet activating factor (Paf) (15–40 μg−1) kills male rabbits within 3 to 5 min. Intravenous injection of Paf at a dose of 15 μg kg−1 is uniformly lethal, and the rabbits died within 4.5 ± 0.4 min. 2 The sudden death is characterized by cessation of respiration, a marked decrease in mean arteri...

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Veröffentlicht in:	British journal of pharmacology 1984-09, Vol.83 (1), p.125-130
Hauptverfasser:	Lefer, Allan M., Müller, Hugo F., Smith, J. Bryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Blood Pressure - drug effects Cyclooxygenase Inhibitors Death, Sudden - etiology In Vitro Techniques Male Muscle, Smooth - drug effects Muscle, Smooth, Vascular - drug effects Platelet Activating Factor - antagonists & inhibitors Platelet Activating Factor - toxicity Pulmonary Artery - drug effects Rabbits Respiration - drug effects Thromboxane B2 - blood Thromboxane-A Synthase - antagonists & inhibitors
Online-Zugang:	Volltext
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