Frusemide releases renin in the rat kidney when prostacyclin synthesis is suppressed

1 The effect of inhibiting prostaglandin (PG) synthesis on basal and frusemide‐stimulated renin secretion was examined in the rat isolated perfused kidney. The stable PGI2 derivative, 6‐keto PGF1α, was measured by radioimmunoassay in urine collected from the kidney. 2 Treatment of rats with indometh...

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Veröffentlicht in:	British journal of pharmacology 1984-06, Vol.82 (2), p.493-499
Hauptverfasser:	Barden, Anne E., Mahoney, Denis P., Tunney, Anne M., Vandongen, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - pharmacology Animals Biological and medical sciences Epoprostenol - biosynthesis Furosemide - pharmacology Indomethacin - pharmacology Kidney - drug effects Kidney - enzymology Male Medical sciences Pharmacology. Drug treatments Propranolol - pharmacology Prostaglandins F - pharmacology Rats Rats, Inbred Strains Renal Circulation - drug effects Renin - metabolism Urinary system
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