Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

This study investigated whether soluble paracrine factors mediated Salmonella-induced IL-8 expression in polarized model intestinal epithelia. We found that the basolateral media of model epithelia that had been apically infected with Salmonella typhimurium for a short period (10 minutes) could acti...

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Veröffentlicht in:	The Journal of clinical investigation 2001-01, Vol.107 (1), p.99-109
Hauptverfasser:	Gewirtz, A T, Simon, Jr, P O, Schmitt, C K, Taylor, L J, Hagedorn, C H, O'Brien, A D, Neish, A S, Madara, J L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Epithelium - immunology Epithelium - microbiology flagellin Flagellin - genetics Flagellin - metabolism Humans Inflammation - etiology Inflammation - immunology Inflammation - microbiology Inflammation Mediators - metabolism interleukin 8 Interleukin-8 - secretion Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Models, Biological Mutation proinflammatory factor Salmonella typhimurium Salmonella typhimurium - genetics Salmonella typhimurium - pathogenicity Salmonella typhimurium - physiology
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