Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation

Background and purpose: Controversy still exists as to whether or not inhaled β2‐adrenoceptor agonists and corticosteroids act synergistically in vivo. In this study, we have used a murine model of lung inflammation to study the synergistic effect of an inhaled β2‐adrenoceptor agonists (formoterol)...

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Veröffentlicht in:	British journal of pharmacology 2007-09, Vol.152 (1), p.83-90
Hauptverfasser:	Wyss, D, Bonneau, O, Trifilieff, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - pharmacology Adrenergic beta-Agonists - therapeutic use Animals Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use asthma Biological and medical sciences Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - pathology Bronchial Hyperreactivity - physiopathology Bronchial Provocation Tests Bronchoalveolar Lavage Fluid - cytology Bronchoconstrictor Agents - administration & dosage Chronic obstructive pulmonary disease, asthma combination corticosteroids Disease Models, Animal Dose-Response Relationship, Drug Drug Combinations Drug Synergism Ethanolamines - administration & dosage Ethanolamines - pharmacology Ethanolamines - therapeutic use Female Formoterol Fumarate Medical sciences Methacholine Chloride - administration & dosage Mice Mice, Inbred BALB C Mometasone Furoate Ovalbumin Pharmacology. Drug treatments Pneumology Pregnadienediols - administration & dosage Pregnadienediols - pharmacology Pregnadienediols - therapeutic use Research Papers Respiratory Function Tests Respiratory Hypersensitivity - chemically induced Respiratory Hypersensitivity - drug therapy Respiratory Hypersensitivity - pathology Respiratory Hypersensitivity - physiopathology Time Factors β2‐adrenoceptor agonists
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