Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy
A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemother...
Gespeichert in:
Veröffentlicht in: | British journal of cancer 1992-11, Vol.66 (5), p.937-942 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 942 |
---|---|
container_issue | 5 |
container_start_page | 937 |
container_title | British journal of cancer |
container_volume | 66 |
creator | MURPHY, D MCGOWN, A. T HALL, A CATTAN, A CROWTHER, D FOX, B. W |
description | A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response rates of these two groups to chemotherapy differ markedly, with patients who have relapsed following initial chemotherapy showing a reduction in response rates to subsequent chemotherapy. Analysis of these data show no statistically significant differences between the glutathione S-transferase activity or isoenzyme distribution in these two groups of patients. Significant differences were observed in the glutathione-S-transferase activities (GST) between tumours and normal ovaries. GST activities in pre-chemotherapy tumours (n = 33, P = 0.01) and post-chemotherapy tumours (n = 20, P = 0.001) where significantly higher than the GST activity in normal ovaries (n = 15). One feature was the expression of the basic isoenzyme which is expressed more in normal ovaries than in tumours. No differences in these parameters were observed in normal peritoneal tissue taken from patients before or after chemotherapy. These data do not support the hypothesis that changes in glutathione S-transferase enzyme activity or isoenzyme expression are major determinants of response to chemotherapy in ovarian tumours. |
doi_str_mv | 10.1038/bjc.1992.389 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1977974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73277795</sourcerecordid><originalsourceid>FETCH-LOGICAL-c433t-1fc4d47099c6c46b78d8722e8f2d3958ad51a83524264bed618fc6973fd6422c3</originalsourceid><addsrcrecordid>eNpVkc-L1DAYhoMo6-zqzauQg3jajvnVprkIy6KrsOBBPYc0_epkbZMxSQfr3f_blBlGPYXwPvmefLwIvaBkSwlv33QPdkuVYlveqkdoQ2vOKtoy-RhtCCGyIoqRp-gypYdyVaSVF-iCCqoaQTbo9904Z5N3LnjAn6scjU8DRJMAG5vdweUFG99jlwL4X8sEuHcpR9fNuTzBzuNwMNEZj_M8hTnizoV9cpBwNt_B4w6GEAGHiM2QIWK75JDDT2ex3cEU8q649ssz9GQwY4Lnp_MKfX3_7svth-r-093H25v7ygrOc0UHK3ohiVK2saLpZNu3kjFoB9ZzVbemr6lpec0Ea0QHfUPbwTZK8qFvBGOWX6G3x7n7uZugt-DLwqPeRzeZuOhgnP4_8W6nv4WDpkpKJUUZ8Po0IIYfM6SsJ5csjKPxEOakJWeykHUBr4-gjSGlCMNZQolea9OlNr3WpkttBX_578f-wseeSv7qlJtkzTiUmqxLZ0yU7RVfrfiIeZPnCOe8uFbVavoDh06v-A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73277795</pqid></control><display><type>article</type><title>Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>MURPHY, D ; MCGOWN, A. T ; HALL, A ; CATTAN, A ; CROWTHER, D ; FOX, B. W</creator><creatorcontrib>MURPHY, D ; MCGOWN, A. T ; HALL, A ; CATTAN, A ; CROWTHER, D ; FOX, B. W</creatorcontrib><description>A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response rates of these two groups to chemotherapy differ markedly, with patients who have relapsed following initial chemotherapy showing a reduction in response rates to subsequent chemotherapy. Analysis of these data show no statistically significant differences between the glutathione S-transferase activity or isoenzyme distribution in these two groups of patients. Significant differences were observed in the glutathione-S-transferase activities (GST) between tumours and normal ovaries. GST activities in pre-chemotherapy tumours (n = 33, P = 0.01) and post-chemotherapy tumours (n = 20, P = 0.001) where significantly higher than the GST activity in normal ovaries (n = 15). One feature was the expression of the basic isoenzyme which is expressed more in normal ovaries than in tumours. No differences in these parameters were observed in normal peritoneal tissue taken from patients before or after chemotherapy. These data do not support the hypothesis that changes in glutathione S-transferase enzyme activity or isoenzyme expression are major determinants of response to chemotherapy in ovarian tumours.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1992.389</identifier><identifier>PMID: 1419640</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adult ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Biopsy ; Female ; Female genital diseases ; Glutathione Transferase - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; Isoenzymes - metabolism ; Medical sciences ; Middle Aged ; Ovarian Neoplasms - enzymology ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - therapy ; Ovary - enzymology ; Ovary - pathology ; Peritoneum - enzymology ; Time Factors ; Tumors</subject><ispartof>British journal of cancer, 1992-11, Vol.66 (5), p.937-942</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-1fc4d47099c6c46b78d8722e8f2d3958ad51a83524264bed618fc6973fd6422c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977974/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977974/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4395935$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1419640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MURPHY, D</creatorcontrib><creatorcontrib>MCGOWN, A. T</creatorcontrib><creatorcontrib>HALL, A</creatorcontrib><creatorcontrib>CATTAN, A</creatorcontrib><creatorcontrib>CROWTHER, D</creatorcontrib><creatorcontrib>FOX, B. W</creatorcontrib><title>Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><description>A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response rates of these two groups to chemotherapy differ markedly, with patients who have relapsed following initial chemotherapy showing a reduction in response rates to subsequent chemotherapy. Analysis of these data show no statistically significant differences between the glutathione S-transferase activity or isoenzyme distribution in these two groups of patients. Significant differences were observed in the glutathione-S-transferase activities (GST) between tumours and normal ovaries. GST activities in pre-chemotherapy tumours (n = 33, P = 0.01) and post-chemotherapy tumours (n = 20, P = 0.001) where significantly higher than the GST activity in normal ovaries (n = 15). One feature was the expression of the basic isoenzyme which is expressed more in normal ovaries than in tumours. No differences in these parameters were observed in normal peritoneal tissue taken from patients before or after chemotherapy. These data do not support the hypothesis that changes in glutathione S-transferase enzyme activity or isoenzyme expression are major determinants of response to chemotherapy in ovarian tumours.</description><subject>Adult</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Glutathione Transferase - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Isoenzymes - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - enzymology</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - therapy</subject><subject>Ovary - enzymology</subject><subject>Ovary - pathology</subject><subject>Peritoneum - enzymology</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc-L1DAYhoMo6-zqzauQg3jajvnVprkIy6KrsOBBPYc0_epkbZMxSQfr3f_blBlGPYXwPvmefLwIvaBkSwlv33QPdkuVYlveqkdoQ2vOKtoy-RhtCCGyIoqRp-gypYdyVaSVF-iCCqoaQTbo9904Z5N3LnjAn6scjU8DRJMAG5vdweUFG99jlwL4X8sEuHcpR9fNuTzBzuNwMNEZj_M8hTnizoV9cpBwNt_B4w6GEAGHiM2QIWK75JDDT2ex3cEU8q649ssz9GQwY4Lnp_MKfX3_7svth-r-093H25v7ygrOc0UHK3ohiVK2saLpZNu3kjFoB9ZzVbemr6lpec0Ea0QHfUPbwTZK8qFvBGOWX6G3x7n7uZugt-DLwqPeRzeZuOhgnP4_8W6nv4WDpkpKJUUZ8Po0IIYfM6SsJ5csjKPxEOakJWeykHUBr4-gjSGlCMNZQolea9OlNr3WpkttBX_578f-wseeSv7qlJtkzTiUmqxLZ0yU7RVfrfiIeZPnCOe8uFbVavoDh06v-A</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>MURPHY, D</creator><creator>MCGOWN, A. T</creator><creator>HALL, A</creator><creator>CATTAN, A</creator><creator>CROWTHER, D</creator><creator>FOX, B. W</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19921101</creationdate><title>Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy</title><author>MURPHY, D ; MCGOWN, A. T ; HALL, A ; CATTAN, A ; CROWTHER, D ; FOX, B. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-1fc4d47099c6c46b78d8722e8f2d3958ad51a83524264bed618fc6973fd6422c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Glutathione Transferase - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Isoenzymes - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ovarian Neoplasms - enzymology</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - therapy</topic><topic>Ovary - enzymology</topic><topic>Ovary - pathology</topic><topic>Peritoneum - enzymology</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURPHY, D</creatorcontrib><creatorcontrib>MCGOWN, A. T</creatorcontrib><creatorcontrib>HALL, A</creatorcontrib><creatorcontrib>CATTAN, A</creatorcontrib><creatorcontrib>CROWTHER, D</creatorcontrib><creatorcontrib>FOX, B. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURPHY, D</au><au>MCGOWN, A. T</au><au>HALL, A</au><au>CATTAN, A</au><au>CROWTHER, D</au><au>FOX, B. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy</atitle><jtitle>British journal of cancer</jtitle><addtitle>Br J Cancer</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>66</volume><issue>5</issue><spage>937</spage><epage>942</epage><pages>937-942</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response rates of these two groups to chemotherapy differ markedly, with patients who have relapsed following initial chemotherapy showing a reduction in response rates to subsequent chemotherapy. Analysis of these data show no statistically significant differences between the glutathione S-transferase activity or isoenzyme distribution in these two groups of patients. Significant differences were observed in the glutathione-S-transferase activities (GST) between tumours and normal ovaries. GST activities in pre-chemotherapy tumours (n = 33, P = 0.01) and post-chemotherapy tumours (n = 20, P = 0.001) where significantly higher than the GST activity in normal ovaries (n = 15). One feature was the expression of the basic isoenzyme which is expressed more in normal ovaries than in tumours. No differences in these parameters were observed in normal peritoneal tissue taken from patients before or after chemotherapy. These data do not support the hypothesis that changes in glutathione S-transferase enzyme activity or isoenzyme expression are major determinants of response to chemotherapy in ovarian tumours.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>1419640</pmid><doi>10.1038/bjc.1992.389</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0007-0920 |
ispartof | British journal of cancer, 1992-11, Vol.66 (5), p.937-942 |
issn | 0007-0920 1532-1827 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1977974 |
source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Adult Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biopsy Female Female genital diseases Glutathione Transferase - metabolism Gynecology. Andrology. Obstetrics Humans Isoenzymes - metabolism Medical sciences Middle Aged Ovarian Neoplasms - enzymology Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Ovary - enzymology Ovary - pathology Peritoneum - enzymology Time Factors Tumors |
title | Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T16%3A32%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glutathione%20S-transferase%20activity%20and%20isoenzyme%20distribution%20in%20ovarian%20tumour%20biopsies%20taken%20before%20or%20after%20cytotoxic%20chemotherapy&rft.jtitle=British%20journal%20of%20cancer&rft.au=MURPHY,%20D&rft.date=1992-11-01&rft.volume=66&rft.issue=5&rft.spage=937&rft.epage=942&rft.pages=937-942&rft.issn=0007-0920&rft.eissn=1532-1827&rft.coden=BJCAAI&rft_id=info:doi/10.1038/bjc.1992.389&rft_dat=%3Cproquest_pubme%3E73277795%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73277795&rft_id=info:pmid/1419640&rfr_iscdi=true |