The shedding of viable cells into the local lymph by tumours growing in the gut of rats
Suspensions of syngeneic sarcoma cells were injected into the Peyer's patches of rats from which the mesenteric nodes had been removed. By later cannulating the thoracic duct of such rats it was possible to collect peripheral intestinal lymph that had come directly from the tumour bearing area...
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| Veröffentlicht in: | British journal of cancer 1985-03, Vol.51 (3), p.379-382 |
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| container_end_page | 382 |
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| container_title | British journal of cancer |
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| creator | Gyure, L A Styles, Jennifer M Dean, C J Nagy, K Hall, J G |
| description | Suspensions of syngeneic sarcoma cells were injected into the Peyer's patches of rats from which the mesenteric nodes had been removed. By later cannulating the thoracic duct of such rats it was possible to collect peripheral intestinal lymph that had come directly from the tumour bearing area without being filtered through a regional node. The number of viable tumour cells in the lymph coming from the tumours was monitored by culturing the whole lymph cells in a limiting dilution assay. The tumours grew to a diameter of approximately 1 cm in 25 days and during this time tumour cells were present in the lymph at a ratio of approximately 1 tumour cell per 10(5) lymph cells. In euthymic rats this number declined as the immune response developed. In athymic rats the number increased by approximately 10 fold during the experiments. It was concluded that the shedding of viable cells parallels the linear, not the volumetric dimensions of the tumour. |
| doi_str_mv | 10.1038/bjc.1985.50 |
| format | Article |
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By later cannulating the thoracic duct of such rats it was possible to collect peripheral intestinal lymph that had come directly from the tumour bearing area without being filtered through a regional node. The number of viable tumour cells in the lymph coming from the tumours was monitored by culturing the whole lymph cells in a limiting dilution assay. The tumours grew to a diameter of approximately 1 cm in 25 days and during this time tumour cells were present in the lymph at a ratio of approximately 1 tumour cell per 10(5) lymph cells. In euthymic rats this number declined as the immune response developed. In athymic rats the number increased by approximately 10 fold during the experiments. It was concluded that the shedding of viable cells parallels the linear, not the volumetric dimensions of the tumour.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1985.50</identifier><identifier>PMID: 3970813</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell Count ; Drug Resistance ; Epidemiology ; Experimental digestive system and abdominal tumors ; Intestinal Neoplasms - pathology ; Lymph - cytology ; Male ; Medical sciences ; Molecular Medicine ; Neoplastic Cells, Circulating ; Oncology ; original-article ; Peyer's Patches - pathology ; Rats ; Rats, Inbred Strains ; Sarcoma, Experimental - pathology ; Thoracic Duct ; Tumors</subject><ispartof>British journal of cancer, 1985-03, Vol.51 (3), p.379-382</ispartof><rights>Cancer Research Campaign 1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-4e234a51dbaff48fd01112cbb7162c16726d576c1a3f9e77d9a6dd475e31812e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976939/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976939/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9077472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3970813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gyure, L A</creatorcontrib><creatorcontrib>Styles, Jennifer M</creatorcontrib><creatorcontrib>Dean, C J</creatorcontrib><creatorcontrib>Nagy, K</creatorcontrib><creatorcontrib>Hall, J G</creatorcontrib><title>The shedding of viable cells into the local lymph by tumours growing in the gut of rats</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Suspensions of syngeneic sarcoma cells were injected into the Peyer's patches of rats from which the mesenteric nodes had been removed. By later cannulating the thoracic duct of such rats it was possible to collect peripheral intestinal lymph that had come directly from the tumour bearing area without being filtered through a regional node. The number of viable tumour cells in the lymph coming from the tumours was monitored by culturing the whole lymph cells in a limiting dilution assay. The tumours grew to a diameter of approximately 1 cm in 25 days and during this time tumour cells were present in the lymph at a ratio of approximately 1 tumour cell per 10(5) lymph cells. In euthymic rats this number declined as the immune response developed. In athymic rats the number increased by approximately 10 fold during the experiments. It was concluded that the shedding of viable cells parallels the linear, not the volumetric dimensions of the tumour.</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell Count</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Experimental digestive system and abdominal tumors</subject><subject>Intestinal Neoplasms - pathology</subject><subject>Lymph - cytology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Medicine</subject><subject>Neoplastic Cells, Circulating</subject><subject>Oncology</subject><subject>original-article</subject><subject>Peyer's Patches - pathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sarcoma, Experimental - pathology</subject><subject>Thoracic Duct</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9vFCEcxYmxqWv15NnIwXhpZ-XHDAwXk6ZR26SJlxqPhAFmls0MrMC02f--jLvZ6METIe_D-355D4B3GK0xou3nbqvXWLTNukEvwAo3lFS4JfwlWCGEeIUEQa_A65S25SpQy8_BORUctZiuwK-HjYVpY41xfoChh49OdaOF2o5jgs7nAHMhxqDVCMf9tNvAbg_zPIU5JjjE8LS8c_4PNcx5sYgqpzfgrFdjsm-P5wX4-e3rw81tdf_j-93N9X2la8ZyVVtCa9Vg06m-r9veIIwx0V3HMSMaM06YaTjTWNFeWM6NUMyYmjeW4hYTSy_Al4Pvbu4ma7T1OapR7qKbVNzLoJz8V_FuI4fwKLHgTFBRDD4dDWL4PduU5eTS8nvlbZiT5I1oWU1YAS8PoI4hpWj70xCM5NKDLD3IpQfZoEK__3uvE3sMvugfj7pKJdo-Kq9dOmECcV5zUrCrA5aK4gcb5bYE70ui_5n64YB7ledoT3aFWZBCPAMr3Kq1</recordid><startdate>19850301</startdate><enddate>19850301</enddate><creator>Gyure, L A</creator><creator>Styles, Jennifer M</creator><creator>Dean, C J</creator><creator>Nagy, K</creator><creator>Hall, J G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19850301</creationdate><title>The shedding of viable cells into the local lymph by tumours growing in the gut of rats</title><author>Gyure, L A ; Styles, Jennifer M ; Dean, C J ; Nagy, K ; Hall, J G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-4e234a51dbaff48fd01112cbb7162c16726d576c1a3f9e77d9a6dd475e31812e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell Count</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Experimental digestive system and abdominal tumors</topic><topic>Intestinal Neoplasms - pathology</topic><topic>Lymph - cytology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Medicine</topic><topic>Neoplastic Cells, Circulating</topic><topic>Oncology</topic><topic>original-article</topic><topic>Peyer's Patches - pathology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sarcoma, Experimental - pathology</topic><topic>Thoracic Duct</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gyure, L A</creatorcontrib><creatorcontrib>Styles, Jennifer M</creatorcontrib><creatorcontrib>Dean, C J</creatorcontrib><creatorcontrib>Nagy, K</creatorcontrib><creatorcontrib>Hall, J G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gyure, L A</au><au>Styles, Jennifer M</au><au>Dean, C J</au><au>Nagy, K</au><au>Hall, J G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The shedding of viable cells into the local lymph by tumours growing in the gut of rats</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1985-03-01</date><risdate>1985</risdate><volume>51</volume><issue>3</issue><spage>379</spage><epage>382</epage><pages>379-382</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Suspensions of syngeneic sarcoma cells were injected into the Peyer's patches of rats from which the mesenteric nodes had been removed. By later cannulating the thoracic duct of such rats it was possible to collect peripheral intestinal lymph that had come directly from the tumour bearing area without being filtered through a regional node. The number of viable tumour cells in the lymph coming from the tumours was monitored by culturing the whole lymph cells in a limiting dilution assay. The tumours grew to a diameter of approximately 1 cm in 25 days and during this time tumour cells were present in the lymph at a ratio of approximately 1 tumour cell per 10(5) lymph cells. In euthymic rats this number declined as the immune response developed. In athymic rats the number increased by approximately 10 fold during the experiments. It was concluded that the shedding of viable cells parallels the linear, not the volumetric dimensions of the tumour.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>3970813</pmid><doi>10.1038/bjc.1985.50</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 1985-03, Vol.51 (3), p.379-382 |
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| language | eng |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animal tumors. Experimental tumors Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Count Drug Resistance Epidemiology Experimental digestive system and abdominal tumors Intestinal Neoplasms - pathology Lymph - cytology Male Medical sciences Molecular Medicine Neoplastic Cells, Circulating Oncology original-article Peyer's Patches - pathology Rats Rats, Inbred Strains Sarcoma, Experimental - pathology Thoracic Duct Tumors |
| title | The shedding of viable cells into the local lymph by tumours growing in the gut of rats |
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