Interaction of estrogen receptor α with proliferating cell nuclear antigen
The ability of estrogen receptor α (ERα) to modulate gene expression is influenced by the recruitment of a host of co-regulatory proteins to target genes. To further understand how estrogen-responsive genes are regulated, we have isolated and identified proteins associated with ERα when it is bound...
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| Veröffentlicht in: | Nucleic acids research 2007-08, Vol.35 (15), p.5028-5038 |
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| container_end_page | 5038 |
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| container_issue | 15 |
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| container_title | Nucleic acids research |
| container_volume | 35 |
| creator | Schultz-Norton, Jennifer R Gabisi, Vivian A Ziegler, Yvonne S McLeod, Ian X Yates, John R Nardulli, Ann M |
| description | The ability of estrogen receptor α (ERα) to modulate gene expression is influenced by the recruitment of a host of co-regulatory proteins to target genes. To further understand how estrogen-responsive genes are regulated, we have isolated and identified proteins associated with ERα when it is bound to DNA containing the consensus estrogen response element (ERE). One of the proteins identified in this complex, proliferating cell nuclear antigen (PCNA), is required for DNA replication and repair. We show that PCNA interacts with ERα in the absence and in the presence of DNA, enhances the interaction of ERα with ERE-containing DNA, and associates with endogenous estrogen-responsive genes. Interestingly, rather than altering hormone responsiveness of endogenous, estrogen-responsive genes, PCNA increases the basal expression of these genes. Our studies suggest that in addition to serving as a platform for the recruitment of DNA replication and repair proteins, PCNA may serve as a platform for transcription factors involved in regulating gene expression. |
| doi_str_mv | 10.1093/nar/gkm533 |
| format | Article |
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Our studies suggest that in addition to serving as a platform for the recruitment of DNA replication and repair proteins, PCNA may serve as a platform for transcription factors involved in regulating gene expression.</description><subject>Cell Line, Tumor</subject><subject>Estradiol - pharmacology</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Humans</subject><subject>Molecular Biology</subject><subject>Proliferating Cell Nuclear Antigen - isolation & purification</subject><subject>Proliferating Cell Nuclear Antigen - metabolism</subject><subject>Response Elements</subject><subject>Transcription, Genetic - drug effects</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1TAQBmALgehpYcMDQDZ0Fzr2-JJskHqhtOJIIEEl1I3lJk5qmmMHxynwWH0RnglXKQVWrLyYz79nPIQ8o_CKQo173sS9_mojEB-QFUXJSl5L9pCsAEGUFHi1Rban6QsA5VTwx2SLKokSKV2Rd6c-2Wia5IIvQlfYKcXQW19E29gxhVj8vCm-uXRZjDEMrss2Od8XjR2Gws_NYE0sjE8u33lCHnVmmOzTu3OHnB2_-XR4Uq7fvz093F-XHVYqlVYZ3kFdgVBN3V0wykTb1mhACNmqDpELiUaBbaVg0FAhmeCNsFZQw5WhuENeL7njfLGxbWN9imbQY3QbE3_oYJz-t-Ldpe7Dtaa1kpzLHLB7FxDD1zmPrDduup3IeBvmScuKMZUf_S_MgVxywAyf_93SfS-_PzqDlwsI8_inCvp2gTovUC8LzK5cnJuS_X4vTbzSUqES-uTzuV5_ODgSB1Dp8-xfLL4zQZs-ukmffWRAEaACxijiL6gxpes</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Schultz-Norton, Jennifer R</creator><creator>Gabisi, Vivian A</creator><creator>Ziegler, Yvonne S</creator><creator>McLeod, Ian X</creator><creator>Yates, John R</creator><creator>Nardulli, Ann M</creator><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070801</creationdate><title>Interaction of estrogen receptor α with proliferating cell nuclear antigen</title><author>Schultz-Norton, Jennifer R ; Gabisi, Vivian A ; Ziegler, Yvonne S ; McLeod, Ian X ; Yates, John R ; Nardulli, Ann M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f387t-e7a4f098057c9fb2125dd93a0556d7f334563a70ed6520c156254c5ee51a47a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Cell Line, Tumor</topic><topic>Estradiol - pharmacology</topic><topic>Estrogen Receptor alpha - metabolism</topic><topic>Humans</topic><topic>Molecular Biology</topic><topic>Proliferating Cell Nuclear Antigen - isolation & purification</topic><topic>Proliferating Cell Nuclear Antigen - metabolism</topic><topic>Response Elements</topic><topic>Transcription, Genetic - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schultz-Norton, Jennifer R</creatorcontrib><creatorcontrib>Gabisi, Vivian A</creatorcontrib><creatorcontrib>Ziegler, Yvonne S</creatorcontrib><creatorcontrib>McLeod, Ian X</creatorcontrib><creatorcontrib>Yates, John R</creatorcontrib><creatorcontrib>Nardulli, Ann M</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Schultz-Norton, Jennifer R</au><au>Gabisi, Vivian A</au><au>Ziegler, Yvonne S</au><au>McLeod, Ian X</au><au>Yates, John R</au><au>Nardulli, Ann M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of estrogen receptor α with proliferating cell nuclear antigen</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>35</volume><issue>15</issue><spage>5028</spage><epage>5038</epage><pages>5028-5038</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><abstract>The ability of estrogen receptor α (ERα) to modulate gene expression is influenced by the recruitment of a host of co-regulatory proteins to target genes. 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Our studies suggest that in addition to serving as a platform for the recruitment of DNA replication and repair proteins, PCNA may serve as a platform for transcription factors involved in regulating gene expression.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>17636311</pmid><doi>10.1093/nar/gkm533</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nucleic acids research, 2007-08, Vol.35 (15), p.5028-5038 |
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| source | Oxford Journals Open Access Collection |
| subjects | Cell Line, Tumor Estradiol - pharmacology Estrogen Receptor alpha - metabolism Humans Molecular Biology Proliferating Cell Nuclear Antigen - isolation & purification Proliferating Cell Nuclear Antigen - metabolism Response Elements Transcription, Genetic - drug effects |
| title | Interaction of estrogen receptor α with proliferating cell nuclear antigen |
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