Temperature preconditioning of isolated rat hearts â a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore

We investigate whether temperature preconditioning (TP), induced by short-term hypothermic perfusion and rewarming, may protect hearts against ischaemic/reperfusion injury like ischaemic preconditioning ( IP ). Isolated rat hearts were perfused for 40 min, followed by 25 min global ischaemia and 60...

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Veröffentlicht in:	The Journal of physiology 2007-06, Vol.581 (3), p.1147-1161
Hauptverfasser:	Khaliulin, Igor, Clarke, Samantha J., Lin, Hua, Parker, Joanna, Suleiman, M.‐Saadeh, Halestrap, Andrew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - prevention & control Cardiovascular Coronary Circulation Hypothermia, Induced In Vitro Techniques Ischemic Preconditioning, Myocardial L-Lactate Dehydrogenase - metabolism Male Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Permeability Transition Pore Mitochondrial Swelling Multienzyme Complexes - metabolism Myocardial Reperfusion Injury - complications Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocardium - pathology NAD - metabolism Necrosis Oxidative Stress Perfusion Phosphocreatine - metabolism Phosphorylation Protein Carbonylation Protein Kinase C-epsilon - metabolism Protein Serine-Threonine Kinases - metabolism Protein Transport Rats Rats, Wistar Reactive Oxygen Species - metabolism Rewarming Signal Transduction Temperature
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Temperature preconditioning of isolated rat hearts â a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore

Temperature preconditioning of isolated rat hearts â a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore