Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies
The tricyclic antidepressants, including desipramine (DMI), are no better than placebo in treating childhood and adolescent depression, but are effective in adult depression. Animal studies comparing the effects of DMI in juveniles and adults are complicated by age-related variations in elimination...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroscience methods 2007-06, Vol.163 (1), p.83-91 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 91 |
|---|---|
| container_issue | 1 |
| container_start_page | 83 |
| container_title | Journal of neuroscience methods |
| container_volume | 163 |
| creator | Kozisek, Megan E. Deupree, Jean D. Burke, William J. Bylund, David B. |
| description | The tricyclic antidepressants, including desipramine (DMI), are no better than placebo in treating childhood and adolescent depression, but are effective in adult depression. Animal studies comparing the effects of DMI in juveniles and adults are complicated by age-related variations in elimination rates. Thus, different dosing regiments are needed to achieve similar brain drug levels in juvenile and adult rats. We compared the half-life of DMI as well as the brain and serum concentrations of DMI and its active metabolite desmethyldesipramine in juvenile and adult rats after various drug administration paradigms. After acute i.p. administration DMI is eliminated from the brain more slowly in postnatal day (PND) 21 and 28 rats as compared to adults. After chronic i.p. administration (for 4–5 days between PND 9 and 28), lower doses of DMI are needed with juvenile rats to obtain the same brain DMI concentrations as adults. By contrast, 2 weeks of continuous drug delivery (minipump) to PND 21–35 and adult rats result in similar brain DMI concentrations. Thus, the pharmacokinetic properties of DMI varies with the age of the animal and dosing of DMI and needs to be carefully adjusted in order to have appropriate brain levels of the drug. |
| doi_str_mv | 10.1016/j.jneumeth.2007.02.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1976307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165027007000829</els_id><sourcerecordid>70462575</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-9db42cda891922e4a65d37647b3722a339a69bd0118c6f352ff7a951f053f0f73</originalsourceid><addsrcrecordid>eNqFkcuO1DAQRSMEYpqBXxhlxS6h7CR2e4MYjXhJI7EBiZ3l2JWOo8QOttMj_h433bxWrKyyT926rlsUNwRqAoS9murJ4bZgGmsKwGugNZDuUbEje04rxvdfHxe7DHYVUA5XxbMYJwBoBbCnxRXhLQAVbFc83K5r8GuwKmFpfLTuUAY82AVdLAcfyhRQpdPttB3R2RnLoFIsH2waS4PRrkEt1uFPNjvKWqMKi9J-9ger1VwqZ8oeR3W0PuQyps1YjM-LJ4OaI764nNfFl3dvP999qO4_vf94d3tf6ZaJVAnTt1QbtRdEUIqtYp1pOGt533BKVdMIxURvgJC9ZkPT0WHgSnRkgK4ZYODNdfH6rLtu_YJGo0vZhcwfXlT4Lr2y8t8XZ0d58EdJBGcNnAReXgSC_7ZhTHKxUeM8K4d-i5JDy2jHuwyyM6iDjzHg8HsIAXnKTE7yV2bylJkEKnNmufHmb4t_2i4hZeDNGcC8qKPFIKO26DQaG1Anabz934wfaaiwfw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70462575</pqid></control><display><type>article</type><title>Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kozisek, Megan E. ; Deupree, Jean D. ; Burke, William J. ; Bylund, David B.</creator><creatorcontrib>Kozisek, Megan E. ; Deupree, Jean D. ; Burke, William J. ; Bylund, David B.</creatorcontrib><description>The tricyclic antidepressants, including desipramine (DMI), are no better than placebo in treating childhood and adolescent depression, but are effective in adult depression. Animal studies comparing the effects of DMI in juveniles and adults are complicated by age-related variations in elimination rates. Thus, different dosing regiments are needed to achieve similar brain drug levels in juvenile and adult rats. We compared the half-life of DMI as well as the brain and serum concentrations of DMI and its active metabolite desmethyldesipramine in juvenile and adult rats after various drug administration paradigms. After acute i.p. administration DMI is eliminated from the brain more slowly in postnatal day (PND) 21 and 28 rats as compared to adults. After chronic i.p. administration (for 4–5 days between PND 9 and 28), lower doses of DMI are needed with juvenile rats to obtain the same brain DMI concentrations as adults. By contrast, 2 weeks of continuous drug delivery (minipump) to PND 21–35 and adult rats result in similar brain DMI concentrations. Thus, the pharmacokinetic properties of DMI varies with the age of the animal and dosing of DMI and needs to be carefully adjusted in order to have appropriate brain levels of the drug.</description><identifier>ISSN: 0165-0270</identifier><identifier>EISSN: 1872-678X</identifier><identifier>DOI: 10.1016/j.jneumeth.2007.02.015</identifier><identifier>PMID: 17400296</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Animals ; Animals, Newborn ; Antidepressant ; Antidepressive Agents, Tricyclic - metabolism ; Antidepressive Agents, Tricyclic - pharmacokinetics ; Behavior, Animal - drug effects ; Brain - drug effects ; Brain - metabolism ; Brain Chemistry - drug effects ; Chromatography, High Pressure Liquid - methods ; Depression ; Desipramine ; Desipramine - metabolism ; Desipramine - pharmacokinetics ; Desmethyldesipramine ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Half-Life ; Imipramine - analogs & derivatives ; Imipramine - metabolism ; Juvenile ; Male ; Pharmacokinetics ; Protein Binding - drug effects ; Rats ; Rats, Sprague-Dawley ; Swimming ; Time Factors</subject><ispartof>Journal of neuroscience methods, 2007-06, Vol.163 (1), p.83-91</ispartof><rights>2007 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-9db42cda891922e4a65d37647b3722a339a69bd0118c6f352ff7a951f053f0f73</citedby><cites>FETCH-LOGICAL-c469t-9db42cda891922e4a65d37647b3722a339a69bd0118c6f352ff7a951f053f0f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165027007000829$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17400296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kozisek, Megan E.</creatorcontrib><creatorcontrib>Deupree, Jean D.</creatorcontrib><creatorcontrib>Burke, William J.</creatorcontrib><creatorcontrib>Bylund, David B.</creatorcontrib><title>Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies</title><title>Journal of neuroscience methods</title><addtitle>J Neurosci Methods</addtitle><description>The tricyclic antidepressants, including desipramine (DMI), are no better than placebo in treating childhood and adolescent depression, but are effective in adult depression. Animal studies comparing the effects of DMI in juveniles and adults are complicated by age-related variations in elimination rates. Thus, different dosing regiments are needed to achieve similar brain drug levels in juvenile and adult rats. We compared the half-life of DMI as well as the brain and serum concentrations of DMI and its active metabolite desmethyldesipramine in juvenile and adult rats after various drug administration paradigms. After acute i.p. administration DMI is eliminated from the brain more slowly in postnatal day (PND) 21 and 28 rats as compared to adults. After chronic i.p. administration (for 4–5 days between PND 9 and 28), lower doses of DMI are needed with juvenile rats to obtain the same brain DMI concentrations as adults. By contrast, 2 weeks of continuous drug delivery (minipump) to PND 21–35 and adult rats result in similar brain DMI concentrations. Thus, the pharmacokinetic properties of DMI varies with the age of the animal and dosing of DMI and needs to be carefully adjusted in order to have appropriate brain levels of the drug.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antidepressant</subject><subject>Antidepressive Agents, Tricyclic - metabolism</subject><subject>Antidepressive Agents, Tricyclic - pharmacokinetics</subject><subject>Behavior, Animal - drug effects</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain Chemistry - drug effects</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Depression</subject><subject>Desipramine</subject><subject>Desipramine - metabolism</subject><subject>Desipramine - pharmacokinetics</subject><subject>Desmethyldesipramine</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Half-Life</subject><subject>Imipramine - analogs & derivatives</subject><subject>Imipramine - metabolism</subject><subject>Juvenile</subject><subject>Male</subject><subject>Pharmacokinetics</subject><subject>Protein Binding - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Swimming</subject><subject>Time Factors</subject><issn>0165-0270</issn><issn>1872-678X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRSMEYpqBXxhlxS6h7CR2e4MYjXhJI7EBiZ3l2JWOo8QOttMj_h433bxWrKyyT926rlsUNwRqAoS9murJ4bZgGmsKwGugNZDuUbEje04rxvdfHxe7DHYVUA5XxbMYJwBoBbCnxRXhLQAVbFc83K5r8GuwKmFpfLTuUAY82AVdLAcfyhRQpdPttB3R2RnLoFIsH2waS4PRrkEt1uFPNjvKWqMKi9J-9ger1VwqZ8oeR3W0PuQyps1YjM-LJ4OaI764nNfFl3dvP999qO4_vf94d3tf6ZaJVAnTt1QbtRdEUIqtYp1pOGt533BKVdMIxURvgJC9ZkPT0WHgSnRkgK4ZYODNdfH6rLtu_YJGo0vZhcwfXlT4Lr2y8t8XZ0d58EdJBGcNnAReXgSC_7ZhTHKxUeM8K4d-i5JDy2jHuwyyM6iDjzHg8HsIAXnKTE7yV2bylJkEKnNmufHmb4t_2i4hZeDNGcC8qKPFIKO26DQaG1Anabz934wfaaiwfw</recordid><startdate>20070615</startdate><enddate>20070615</enddate><creator>Kozisek, Megan E.</creator><creator>Deupree, Jean D.</creator><creator>Burke, William J.</creator><creator>Bylund, David B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070615</creationdate><title>Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies</title><author>Kozisek, Megan E. ; Deupree, Jean D. ; Burke, William J. ; Bylund, David B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-9db42cda891922e4a65d37647b3722a339a69bd0118c6f352ff7a951f053f0f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antidepressant</topic><topic>Antidepressive Agents, Tricyclic - metabolism</topic><topic>Antidepressive Agents, Tricyclic - pharmacokinetics</topic><topic>Behavior, Animal - drug effects</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain Chemistry - drug effects</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Depression</topic><topic>Desipramine</topic><topic>Desipramine - metabolism</topic><topic>Desipramine - pharmacokinetics</topic><topic>Desmethyldesipramine</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Half-Life</topic><topic>Imipramine - analogs & derivatives</topic><topic>Imipramine - metabolism</topic><topic>Juvenile</topic><topic>Male</topic><topic>Pharmacokinetics</topic><topic>Protein Binding - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Swimming</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kozisek, Megan E.</creatorcontrib><creatorcontrib>Deupree, Jean D.</creatorcontrib><creatorcontrib>Burke, William J.</creatorcontrib><creatorcontrib>Bylund, David B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroscience methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kozisek, Megan E.</au><au>Deupree, Jean D.</au><au>Burke, William J.</au><au>Bylund, David B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies</atitle><jtitle>Journal of neuroscience methods</jtitle><addtitle>J Neurosci Methods</addtitle><date>2007-06-15</date><risdate>2007</risdate><volume>163</volume><issue>1</issue><spage>83</spage><epage>91</epage><pages>83-91</pages><issn>0165-0270</issn><eissn>1872-678X</eissn><abstract>The tricyclic antidepressants, including desipramine (DMI), are no better than placebo in treating childhood and adolescent depression, but are effective in adult depression. Animal studies comparing the effects of DMI in juveniles and adults are complicated by age-related variations in elimination rates. Thus, different dosing regiments are needed to achieve similar brain drug levels in juvenile and adult rats. We compared the half-life of DMI as well as the brain and serum concentrations of DMI and its active metabolite desmethyldesipramine in juvenile and adult rats after various drug administration paradigms. After acute i.p. administration DMI is eliminated from the brain more slowly in postnatal day (PND) 21 and 28 rats as compared to adults. After chronic i.p. administration (for 4–5 days between PND 9 and 28), lower doses of DMI are needed with juvenile rats to obtain the same brain DMI concentrations as adults. By contrast, 2 weeks of continuous drug delivery (minipump) to PND 21–35 and adult rats result in similar brain DMI concentrations. Thus, the pharmacokinetic properties of DMI varies with the age of the animal and dosing of DMI and needs to be carefully adjusted in order to have appropriate brain levels of the drug.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17400296</pmid><doi>10.1016/j.jneumeth.2007.02.015</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0270 |
| ispartof | Journal of neuroscience methods, 2007-06, Vol.163 (1), p.83-91 |
| issn | 0165-0270 1872-678X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1976307 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Factors Animals Animals, Newborn Antidepressant Antidepressive Agents, Tricyclic - metabolism Antidepressive Agents, Tricyclic - pharmacokinetics Behavior, Animal - drug effects Brain - drug effects Brain - metabolism Brain Chemistry - drug effects Chromatography, High Pressure Liquid - methods Depression Desipramine Desipramine - metabolism Desipramine - pharmacokinetics Desmethyldesipramine Dose-Response Relationship, Drug Drug Administration Schedule Half-Life Imipramine - analogs & derivatives Imipramine - metabolism Juvenile Male Pharmacokinetics Protein Binding - drug effects Rats Rats, Sprague-Dawley Swimming Time Factors |
| title | Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T03%3A51%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Appropriate%20dosing%20regimens%20for%20treating%20juvenile%20rats%20with%20desipramine%20for%20neuropharmacological%20and%20behavioral%20studies&rft.jtitle=Journal%20of%20neuroscience%20methods&rft.au=Kozisek,%20Megan%20E.&rft.date=2007-06-15&rft.volume=163&rft.issue=1&rft.spage=83&rft.epage=91&rft.pages=83-91&rft.issn=0165-0270&rft.eissn=1872-678X&rft_id=info:doi/10.1016/j.jneumeth.2007.02.015&rft_dat=%3Cproquest_pubme%3E70462575%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70462575&rft_id=info:pmid/17400296&rft_els_id=S0165027007000829&rfr_iscdi=true |